DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and CYP3A7

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens

Alignment Length:	511	Identity:	161/511 - (31%)
Similarity:	259/511 - (50%)	Gaps:	34/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRN 68
            |:.|..|::.||.:.....|   ..||:.|||...|.|..||...::|.....::  |.|.|||.
Human    11 TWLLLAVSLILLYLYGTRTH---GLFKKLGIPGPTPLPFLGNALSFRKGYWTFDM--ECYKKYRK 70

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDP---MSAHLFNLDGPQW 129
                ..|.|..|:|...:.|.::.|.:|:|. :|.||::..:     .|   |...:...:..:|
Human    71 ----VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKNAISIAEDEEW 126

  Fly   130 RLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGI 194
            :.:||.||.||||||:|.|.|.:....:..:..:..:......:.::.:...:::|||.:.:||:
Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV 191

  Fly   195 KCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTA---QIQEFYQRIVKE 256
            ..:||.:.:..|:...::.|..:.....|..: :.:|.|...|.....|.   ::..|..:.||:
Human   192 SIDSLNNPQDPFVENTKKLLRFNPLDPFVLSI-KVFPFLTPILEALNITVFPRKVISFLTKSVKQ 255

  Fly   257 TVTLREKENIK-RNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMG 320
            ....|.||..| |.||:.::|..:|.|     :.|..|.|:..|::||:.:|..||::|:||.:.
Human   256 IKEGRLKETQKHRVDFLQLMIDSQNSK-----DSETHKALSDLELMAQSIIFIFAGYETTSSVLS 315

  Fly   321 FALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAK 385
            |.:||||.:|.:|.||:.|:..||...... ||:.:..|:|||.|:|||||.:.:...::||..|
Human   316 FIIYELATHPDVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKK 379

  Fly   386 RFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRN 450
            ...:.|   ..|..|..|:|||..:||||..:.||.:|.|||||.:.........:.|||.||||
Human   380 DVEING---MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

  Fly   451 CIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGIKGGIQLKVEA 506
            |||:||..:..::.|..:::||:|.||..|..||.. ....:||..| .|.||.|:
Human   442 CIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL-RFGGLLLTEK-PIVLKAES 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	148/473 (31%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	148/475 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820