DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	444	Identity:	116/444 - (26%)
Similarity:	195/444 - (43%)	Gaps:	81/444 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 KGIYYNEKDDPMSAHLFN------------LDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEE 158
            |.:|  .:.||.:|::::            |:||:|...|..|:..|....:|   |.|...||.
Mouse   101 KAVY--SRGDPKAAYVYDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLK---PYVAIFAES 160

  Fly   159 FMAVM---HEKVSENSILDVRDLVARFTVDVIGTCAFGIKCNSL-RDEKAEFLHFGRRALL---- 215
            ...::   .:|.|||...|:...|....:|.:..|.||...:.| ..:.:.:|......||
Mouse   161 TRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQR 225

  Fly   216 -DS--RHGNLVSGLMRSYPNLARRLGLC------------RNTAQIQEFYQRIVKETVTLREKEN 265
             ||  .|.:.:..|.   |:..|.|..|            :..|.:|:     .||...|:|:.:
Mouse   226 IDSFQYHNDFIYWLT---PHGRRFLRACQIAHDHTDHVIRQRKAALQD-----EKEQKKLQERRH 282

  Fly   266 IKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYELAKNP 330
            :   ||:|:|:|.:::..:.|.:.         ::.|:...|...|.||::|.:.:.||.:|..|
Mouse   283 L---DFLDILLGARDESGIKLSDA---------DLRAEVDTFMFEGHDTTTSGISWFLYCMALYP 335

  Fly   331 SIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFV-VPGNPK 394
            ..|.:.|.|:.::|...| .|.::.:..:.||...:.|..|.|..||.|.|..:|... |.|..
Mouse   336 MHQQRCREEVREILGDRD-SFQWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRS- 398

  Fly   395 FVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQM 459
              :.||..:.:...|:|.:.:::|:|..|.|.|||||....|...|::||..|||||||.:|...
Mouse   399 --LPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMN 461

  Fly   460 QARIGLAMLIKNFTFSPCSATPDPLTFDPHS------AILLGIKGGIQLKVEAI 507
            :.::..|:.:..|.|||          ||..      .::|..|.||.|.::.:
Mouse   462 EMKVVTALCLLRFEFSP----------DPSKIPIKVPQLILRSKNGIHLYLKPL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	116/439 (26%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	115/437 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900