DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	513	Identity:	162/513 - (31%)
Similarity:	261/513 - (50%)	Gaps:	50/513 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VALLAIVTYILHRKLT----YFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAP 72
            :.||||:..:|:|..|    .||::|||..||.|..|.:..|.|  .:.:...|.|.||..:...
Mouse    12 LVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLNYYK--GLWKFDMECYEKYGKTWGL 74

  Fly    73 FVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDP---MSAHLFNLDGPQWRLLR 133
            |.|    |.|...:.|.|..|.:|:|. ||.||::..::     |   ||..:......:|:..|
Mouse    75 FDG----QIPLFVITDPETIKNVLVKECFSVFTNRQDFF-----PVGIMSKSISLAKDEEWKRYR 130

  Fly   134 SKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIKCNS 198
            :.||.|||||.:|.|:|.:....:..:..:.::..:...:.|:|::..:::|||.:..||:..:|
Mouse   131 ALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNIDS 195

  Fly   199 LRDEKAEFLHFGRRAL-LDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFYQRIV-KETV 258
            |.:.:..|:...::.| .|  :.:.:|..:..:|.|.   ..|.:|.......||:::.| :.|.
Mouse   196 LNNPEDPFVENAKKVLRFD--YFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEFFKKFVDRMTE 258

  Fly   259 TLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFAL 323
            ...:.:...|.||:.:::...|:.    ::.:..|.|:..||.||:.:|..||::|:||.:.|.:
Mouse   259 NRLDSKQKHRVDFIYLMMEAYNKS----KDKDSHKALSEIEITAQSIIFIFAGYETTSSILSFTV 319

  Fly   324 YELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFV 388
            |.||.:|.||.|::.|:.:.|...... ||:.:..::|||.|:|||||.|.|...:.||..|...
Mouse   320 YSLATHPDIQKKLQEEIDEALPNKAPP-TYDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKDVE 383

  Fly   389 VPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIG 453
            :.|   ..|..|.:|||||..:||||..:|||.||:|||||.|.........:||||.|||||||
Mouse   384 ING---IYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCIG 445

  Fly   454 LRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFD----------------PHSAILLG 495
            :||..|..::.|..:::||:|.||..|..||...                |..|::.|
Mouse   446 MRFALMNMKLALIKVLQNFSFQPCKETQIPLKLSRELLLQPVKPIVLKVVPRDAVITG 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	150/483 (31%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	148/475 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720