Protein Alignment Cyp6a18 and Cyp3a11

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_031844.1
• Gene: Cyp3a11 / 13112
• MGIID: 88609
• Length: 504
• Species: Mus musculus
• Alignment Length: 509
• Identity: 166/509 - (32%)
• Similarity: 259/509 - (50%)
• Gaps: 54/509 - (10%)

  Fly    14 LLAIVTYILH----RKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAPFV 74
            ||||...:|:    ||...||::|||..||.|..|.:..|.|  .:.:...|.|.||..:...|.
Mouse    14 LLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYK--GLWKFDMECYKKYGKTWGLFD 76

  Fly    75 GFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK------GIYYN----EKDDPMSAHLFNLDGPQ 128
            |    |.|...|.|.|..|.:|:|. ||.||::      ||...    .|||            :
Mouse    77 G----QTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGIMSKAISISKDD------------E 125

  Fly   129 WRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFG 193
            |:..|:.||.||||||:|.|:|.:....:..:..:.:|..:...:.::|::..:::|||.:.:||
Mouse   126 WKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSFG 190

  Fly   194 IKCNSLRDEKAEFLHFGRRAL-LDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFYQRIV 254
            :..:||.:.:..|:...::.| .|.....|.|.::  :|.|.   ..|.:|.......||:::.|
Mouse   191 VNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVL--FPFLTPVYEMLNICMFPKDSIEFFKKFV 253

  Fly   255 KETVTLR-EKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSST 318
            ......| :.:...|.||:.:::...|.....:.:    |.|:..||.||:.:|..||::|:|||
Mouse   254 DRMKESRLDSKQKHRVDFLQLMMNSHNNSKDKVSH----KALSDMEITAQSIIFIFAGYETTSST 314

  Fly   319 MGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVA 383
            :.|.|:.||.:|.||.|::.|:.:.|...... ||:.:.:::|||.|:|||||.|.|...::||.
Mouse   315 LSFTLHSLATHPDIQKKLQDEIDEALPNKAPP-TYDTVMEMEYLDMVLNETLRLYPIANRLERVC 378

  Fly   384 AKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGP 448
            .|...:.|   ..|..|.:|:|||.|:||||..:.||.||:|||||.|.........:||||.||
Mouse   379 KKDVELNG---VYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGP 440

  Fly   449 RNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPL------TFDPHSAILLGI 496
            |||:|:||..|..::.|..:::||:|.||..|..||      ...|...|:|.:
Mouse   441 RNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	144/449 (32%)
Cyp3a11	NP_031844.1	CYP3A	67..493	CDD:410743	145/451 (32%)