Protein Alignment Cyp6a18 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 129/579 - (22%)
• Similarity: 226/579 - (39%)
• Gaps: 156/579 - (26%)

  Fly     3 LTYFLFQVAVALLAIVT--YILHRKLTYFKRRGIPYDKPHPLRGN---------------MEGYK 50
            |.:|||::.:..|.:..  ||..|:|..|         |.|.|.|               ::..|
Human    31 LLFFLFRLLLRFLRLCRSFYITCRRLRCF---------PQPPRRNWLLGHLGMYLPNEAGLQDEK 86

  Fly    51 KT-RTVHE---------------IHQEYYNKYRNSKAPFVG----FYLFQKPAAFVIDLELAKQI 95
            |. ..:|.               :|.:|......:.|....    ||.|.||
Human    87 KVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKP------------- 138

  Fly    96 LIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFM 160
                   :...|:..::             |.:|...|..|:..|....:|    ..:.:..:..
Human   139 -------WLGDGLLLSK-------------GDKWSRHRRLLTPAFHFDILK----PYMKIFNQSA 179

  Fly   161 AVMHEK---VSENSI--LDVRDLVARFTVDVIGTCAFGIKCN------------------SLRDE 202
            .:||.|   ::|.|.  ||:.:.::..|:|.:..|.|....|                  |:|.:
Human   180 DIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQ 244

  Fly   203 -----KAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVKE---TVT 259
                 ..:|::: |.|  |.|.......::..:           .|..||| .:|.:::   ...
Human   245 YRLHHYLDFIYY-RSA--DGRRFRQACDMVHHF-----------TTEVIQE-RRRALRQQGAEAW 294

  Fly   260 LREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALY 324
            |:.|:. |..||:|:|:         |...|..|.|:.::|.|:|..|...|.||:||.:.:.|:
Human   295 LKAKQG-KTLDFIDVLL---------LARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLF 349

  Fly   325 ELAKNPSIQDKVRAELGQVLEQHD-QKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFV 388
            .|||.|..|:|.|.|:.:|::..: ::..::.:..|.:....|.|:||.|..|..|.|...:...
Human   350 NLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIK 414

  Fly   389 VPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIG 453
            :|...  :|..|...::.....||:|:::|:...:.|.||.|:...:|..:|::||..|||||||
Human   415 LPDGR--IIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIG 477

  Fly   454 LRFGQMQARIGLAMLIKNFTFS-----PCSATPDPLTFDPHSAILLGIKGGIQLKVEAI 507
            ..|...:.|:.:|:.:..|..|     .....|:         ::|..:.|:.||||.:
Human   478 QSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPE---------LILRTENGLWLKVEPL 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	105/470 (22%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	111/513 (22%)