Protein Alignment Cyp6a18 and CYP4F8

DIOPT Version :9

• Sequence 1: NP_001287562.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 124/465 - (26%)
• Similarity: 219/465 - (47%)
• Gaps: 64/465 - (13%)

  Fly    75 GFYLFQKPAAFVIDL---ELAKQILIKNFSN-FTDKGIYYNEKDDP-MSAHLFNLDGPQWRLLRS 134
            ||..:..|...:|:|   ::.:.::  |.|: .|||.|.:.:...| :...|....|.:||..|.
Human    87 GFVRWLGPITPIINLCHPDIVRSVI--NTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRR 149

  Fly   135 KLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEK-----VSENSILDVRDLVARFTVDVIGTCAFGI 194
            .|:..|....:|    ..:.:..:...:||.|     :..::.|||.:.::..|:|.:..|.|..
Human   150 LLTPAFHFNILK----PYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSF 210

  Fly   195 KCNSLRDEKAEFLH--FGRRALLDSRHGNLVSGLMRSYPNLARRLGLC-----RNTAQIQEFYQR 252
            ..| .:::.:|::.  ....||:..|:....     .|.:....|..|     |....:.:|...
Human   211 DSN-CQEKPSEYITAIMELSALVVKRNNQFF-----RYKDFLYFLTPCGRRFHRACRLVHDFTDA 269

  Fly   253 IVKE---TVT-------LREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVF 307
            :::|   |:|       |:.|...|..||:|:|: |...||        .|.|:.::|.|:|..|
Human   270 VIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLL-LSEDKN--------GKELSDEDIRAEADTF 325

  Fly   308 FIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQK-FTYECIKDLKYLDQVINETLR 371
            ...|.||::|.:.:.||.||::|..|::.|.|:.::|:..:.| ..::.:..|.:|...:.|:||
Human   326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLR 390

  Fly   372 HYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKR 436
            .:..:|...|...:..|:|.:.  ||..|....|...||||:||::|:|..:.|.||.||.:.||
Human   391 LHPPIPTFARGCTQDVVLPDSR--VIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKR 453

  Fly   437 PSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSP----CSATPDPLTFDPHSAILLGIK 497
            ..:|::||..|||||||.:|...:.::.||:.:..|...|    ...||:         |:|..:
Human   454 SPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPE---------IVLRAE 509

  Fly   498 GGIQLKVEAI 507
            .|:.|:||.:
Human   510 DGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	122/460 (27%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	118/448 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810