Protein Alignment Cyp6a18 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 115/504 - (22%)
• Similarity: 216/504 - (42%)
• Gaps: 94/504 - (18%)

  Fly    10 VAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKT-----RTVHEIHQEYYNKYRNS 69
            |.:|.....|::...:..|....|.|  :|..|.|::..:.|.     |.:.::..::..||
Human    12 VLLAFGLCCTFVHRARSRYEHIPGPP--RPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKY--- 71

  Fly    70 KAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDG-------- 126
             .|.|...:|.|.:..|...|..|:.|:..         .|| ||..|...|..:.|
Human    72 -GPVVRVNVFHKTSVIVTSPESVKKFLMST---------KYN-KDSKMYRALQTVFGERLFGQGL 125

  Fly   127 ------PQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVD 185
                  .:|...|..:...|:...:..:..|....||:.:.::..|....:.:.::|::....:|
Human   126 VSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMD 190

  Fly   186 VIGTCAFGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRL-GLCRNTAQIQE- 248
            ::...|||::.:.|         .|.:..|......::.|:..|...||:.| |..:...:::|
Human   191 ILAKAAFGMETSML---------LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRES 246

  Fly   249 --FYQRIVKETVTLREKENIKRNDFM--DMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFV-FF 308
              |.:::.::.|. |.:|.:||.:.:  |:|..:...:          :|...||.:...|| ||
Human   247 IRFLRQVGRDWVQ-RRREALKRGEEVPADILTQILKAE----------EGAQDDEGLLDNFVTFF 300

  Fly   309 IAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHY 373
            |||.:||::.:.|.:.||::.|.|..:::||:.:|:.. .:...:|.:..|:||.||:.|:||.|
Human   301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGS-KRYLDFEDLGRLQYLSQVLKESLRLY 364

  Fly   374 -------------TIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRP 425
                         |::..|.        ||||        ..::..:..:....:.:.:|..|.|
Human   365 PPAWGTFRLLEEETLIDGVR--------VPGN--------TPLLFSTYVMGRMDTYFEDPLTFNP 413

  Fly   426 ERFSPEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTF 474
            :||.|  .|.:|...:.||..|.|:|||.:|.||:.::.:|.|::...|
Human   414 DRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	102/439 (23%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	104/453 (23%)