DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a18 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	531	Identity:	136/531 - (25%)
Similarity:	231/531 - (43%)	Gaps:	71/531 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAIV---TYILHRKLTYFKRRGIPYDKPHPLRGN-MEGY--KKTRTVHEIHQEYYNKYRNSKAP 72
            |||.|   |||.:|  ||...    .|.|.|.:.| ..|:  ..|.|.|.:     .:..|..|.
Mouse    35 LLARVLTQTYIFYR--TYHHL----CDFPQPPKWNWFLGHLGMITPTEHGL-----KEVTNLVAT 88

  Fly    73 F-VGFYLFQKPAAFVIDL---ELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRLLR 133
            : .||..:..|...:|.|   ::.:.:|..:.|....:.::|:.....:...|...||.:|...|
Mouse    89 YPQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALKEVVFYSFLKPWLGDGLLLSDGDKWSSHR 153

  Fly   134 SKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSE-----NSILDVRDLVARFTVDVIGTCAFG 193
            ..|:..|....:|    ..|.:..:...:||.|...     ::.|||.:.::..|:|.:..|.|.
Mouse   154 RMLTPAFHFNILK----PYVKIFNDSTNIMHAKWQHLASGGSARLDVFENISLMTLDSLQKCVFS 214

  Fly   194 IKCNSLRDEKAEFLH--FGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVK- 255
            ...| .::..:|::.  ....||:..|:..|:..:...|..........:....:..|...:::
Mouse   215 FDSN-CQENPSEYISAILELSALVTKRYHQLLLHIDSLYQLTCSGRRFHKACHLVHSFTDAVIQD 278

  Fly   256 ---------ETVTLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAG 311
                     |...|:.|...|..||:|:|:..|:      |:|   |.|:.::|.|:|..|...|
Mouse   279 RRRTLPSKHEDDVLKAKAKSKTLDFIDVLLLSKD------EDG---KELSDEDIRAEADTFMFEG 334

  Fly   312 FDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQK--------FTYECIKDLKYLDQVINE 368
            .||::|.:.:.||.||::|..|::.|.|:.::|...:..        |..:.:..|.:|...|.|
Mouse   335 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTEIECSCAVFLRDDLAQLPFLTMCIKE 399

  Fly   369 TLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEES 433
            :||.:..|..:.|...:..|:|...  ||..|...||...|.||:|:::|:|..:.|.||.||..
Mouse   400 SLRLHPPVTVISRRCTQDIVLPDGR--VIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENI 462

  Fly   434 AKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATP--DPLTFDPHSAILLGI 496
            ..|..:|::||..|||||||..|...:.::.||:.:..|...|....|  .|       .::|..
Mouse   463 KDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKP-------ELILRA 520

  Fly   497 KGGIQLKVEAI 507
            :||:.|:||.:
Mouse   521 EGGLWLRVEPL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	123/499 (25%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	122/496 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900