Protein Alignment Cyp6a18 and cyp3a4

DIOPT Version :10

• Sequence 1: NP_651563.1
• Gene: Cyp6a18 / 43304
• FlyBaseID: FBgn0039519
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: XP_002943949.2
• Gene: cyp3a4 / 100494419
• XenbaseID: XB-GENE-984218
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 514
• Identity: 151/514 - (29%)
• Similarity: 253/514 - (49%)
• Gaps: 53/514 - (10%)

  Fly     4 TYFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRN 68
            |:.|  :||.|:.|:.|.:. ....||:.|||...|.|..|....::|.....:|  |.:.||
 Frog    11 TWIL--LAVLLVLILLYGIW-PYGLFKKMGIPGPTPLPFIGTFLEFRKGMIQFDI--ECFKKY-- 68

  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDKGIYYNEKDDPMSAHLFNLDGP----- 127
              ....|.|..::|...::|..:.|.||:|. ::|||::             ..|.|:||
 Frog    69 --GRMWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNR-------------RNFGLNGPLESAI 118

  Fly   128 ------QWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDV 186
                  ||:.:||.||.||||||:|.|:..:...::..:..:...|.::.....:|::..:::||
 Frog   119 TVAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDKDEPCATKDVIGAYSMDV 183

  Fly   187 IGTCAFGIKCNSLRDEKAEF-LHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFY 250
            |.:.:|.:..:||::....| :|.  :.||.:...:.|......:|.|.....:...:...::|.
 Frog   184 ITSTSFSVNIDSLQNPSNPFVIHI--KNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDFT 246

  Fly   251 QRIVKETVTLREK----ENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAG 311
            |..:....:.|||    ::..|.|.:.:::.....:.....|..  |.||..||:||:.:|..||
 Frog   247 QFFMNAVTSFREKRKKGDHSGRVDLLQLMVDSGTTEGNDSSNQH--KALTDAEIMAQSLIFIFAG 309

  Fly   312 FDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIV 376
            ::|:|:.:.:..|.||.:|.:|.|:..|:...|...... ||:.:..::|||.||.||||.:...
 Frog   310 YETTSTALSYLFYNLATHPDVQQKLHEEIDSFLPDKASP-TYDILMQMEYLDMVIQETLRLFPPA 373

  Fly   377 PNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAW 441
            ..::||:.:...:.|   ..|..|...:||:..:..||..:|||.||||||||.|..|.:....:
 Frog   374 GRLERVSKQNVEING---VSIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQTPFTF 435

  Fly   442 LPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTF------DPHSAILL 494
            ||||:||||||||||..:..::.:|.|::||:..||:.|..|:.|      .|...|:|
 Frog   436 LPFGDGPRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFSTIGVLQPKKPIVL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_651563.1	CYP6-like	70..500	CDD:410679	131/448 (29%)
cyp3a4	XP_002943949.2	CYP3A	67..495	CDD:410743	133/453 (29%)