DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	516	Identity:	151/516 - (29%)
Similarity:	264/516 - (51%)	Gaps:	63/516 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LAIVTYIL--------HRKLTY----FKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYR 67
            |:|.|::|        :...||    ||:.|||..||.||.|.:..|  ...:.:..::.|.||
Mouse     7 LSIETWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNY--FDGMWKFDEDCYKKY- 68

  Fly    68 NSKAPFVGFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK----GIYYNEKDDPMSAHLFNLDGP 127
               ....|||:..||...::|.|:.|.:|:|. :|.||::    .:.:.:|...:|      :..
Mouse    69 ---GKIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTLGPVGFLKKSITIS------EDE 124

  Fly   128 QWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAF 192
            :|:.||:.||.||||||:|.|:|.:....:..:..:..:..:...::::|:...:::|||...:|
Mouse   125 EWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVITGTSF 189

  Fly   193 GIKCNSLRDEKAEFLHFGRRAL----LDSRHGNLVSGLMRSYPNLA---RRLGLC---RNTAQ-I 246
            |:..:||.:.:..|:...::.|    .|.   .|:|.::  :|.|.   ..|.|.   |::.. .
Mouse   190 GVNIDSLNNPQNPFVQKTKKILKFKIFDP---FLLSTIL--FPFLTPIYEMLNLSIFPRDSMNFF 249

  Fly   247 QEFYQRIVKETVTLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAG 311
            ::|.:|:.||.:..::|..:   ||:.:::..:|.|..     |..|.|:..|:.|||.:|...|
Mouse   250 KKFVKRMKKERLASKQKNRV---DFLQLMMNTQNSKGQ-----ESQKALSDLEMAAQAVIFIFGG 306

  Fly   312 FDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIV 376
            :|.:|:::...:||||.:|.:|.|::.|:.:.| .:....||:.:.|::|||.|:||:||.|...
Mouse   307 YDATSTSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLDMVVNESLRLYPTA 370

  Fly   377 PNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAW 441
            ..::||:.|...:.|   ..|..|..|:||...:|.:|..:|||.||.|.|||.|.........:
Mouse   371 IRLERVSKKDVEING---VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYIY 432

  Fly   442 LPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPL------TFDPHSAILLGI 496
            :|||.|||||:.:||..:..::.:..:::|||..||..|..||      .|.|...|:|.:
Mouse   433 MPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKISREPVFQPEKPIILKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	140/481 (29%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	141/482 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720