DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a18 and Cyp3a41b

DIOPT Version :9

Sequence 1:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001098629.1	Gene:	Cyp3a41b / 100041375	MGIID:	3714859	Length:	504	Species:	Mus musculus

Alignment Length:	504	Identity:	164/504 - (32%)
Similarity:	260/504 - (51%)	Gaps:	44/504 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAIVTYILHRKLT----YFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNSKAPFV 74
            ||||:..:|:|..|    .||::|||..||.|..|.:..|.|  .:.:...|.|.||..:...|.
Mouse    14 LLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYK--GLWKFDMECYEKYGKTWGLFD 76

  Fly    75 GFYLFQKPAAFVIDLELAKQILIKN-FSNFTDK------GIYYNEKDDPMSAHLFNLDGPQWRLL 132
            |    |.|...:.|.|:.|.:|:|. ||.||::      ||        ||..:......:|:..
Mouse    77 G----QMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGI--------MSKAISISKDEEWKRY 129

  Fly   133 RSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTCAFGIKCN 197
            |:.||.||||||:|.|:|.:....:..:..:.::..:...:.::|::..:::|||.:.:||:..:
Mouse   130 RALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSIDVITSTSFGVNVD 194

  Fly   198 SLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLA---RRLGLCRNTAQIQEFYQRIVKETVT 259
            ||.:.:..|:...:..|.......||..:: .:|.|.   ..|.:|.......||:::.|.....
Mouse   195 SLNNPEDPFVEKAKGILRVDFFDPLVFSVV-LFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKE 258

  Fly   260 LR-EKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFAL 323
            .| :.:...|.||:.:::...|..    ::.:..|.|:..||.||:.||..||::|:|||:.|.|
Mouse   259 SRLDSKQKHRVDFLQLMMNAHNNS----KDKDSHKALSDMEITAQSIVFIFAGYETTSSTLSFTL 319

  Fly   324 YELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFV 388
            |.||.:|.||.|::.|:.:.|...... ||:.:.:::|||.|:|||||.|.|...::|...|...
Mouse   320 YCLATHPDIQKKLQEEIDETLPNKAPP-TYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVE 383

  Fly   389 VPGNPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIG 453
            :.|   ..|..|.:|:|||.|:||||..:|||.||:|||||.|.........::|||.|||||||
Mouse   384 LNG---VYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIG 445

  Fly   454 LRFGQMQARIGLAMLIKNFTFSPCSATPDPL------TFDPHSAILLGI 496
            :||..|..::.|..:::||:|.||..|..||      ...|...|:|.:
Mouse   446 MRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	152/476 (32%)
Cyp3a41b	NP_001098629.1	p450	39..494	CDD:278495	153/477 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720