DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13978 and Enpp1

DIOPT Version :9

Sequence 1:NP_651562.2 Gene:CG13978 / 43303 FlyBaseID:FBgn0039518 Length:898 Species:Drosophila melanogaster
Sequence 2:NP_445987.1 Gene:Enpp1 / 85496 RGDID:628825 Length:906 Species:Rattus norvegicus


Alignment Length:438 Identity:87/438 - (19%)
Similarity:147/438 - (33%) Gaps:129/438 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 PPADRLVVFVTDGLRA------------ATFLANNGSDVPDLKDIYRQQGRIGISRTCAPTMTRP 95
            ||.   ::|..||.||            .:.|.|.|:...:::.:|             ||.|.|
  Rat   192 PPT---LLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPVY-------------PTKTFP 240

  Fly    96 GHIAIFAGFHEDPAASLMHLCYNP---GDFDTVFNRSRNMIGWAHSYIVGYFVKLSHGGAPLRFD 157
            .|.:|..|.:.:....:.:..|:|   ..|........|.:.:....|   :|..:|  ..:|..
  Rat   241 NHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPI---WVTANH--QEVRSG 300

  Fly   158 SY------MERD--LPEKLTCDKWAFDKVEN----FLRNVDNVREWRNY----KPAVFFVYLADM 206
            :|      :|.|  ||:        ..||.|    |...:..|.||...    :|..:.:||.:.
  Rat   301 TYFWPGSDVEIDGILPD--------IYKVYNGSVPFEERILAVLEWLQLPSYERPHFYTLYLEEP 357

  Fly   207 DIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVFNDSRTAYLMTSDHGM-------------- 257
            |.:.|...|:|.:....||.....:....:..:.:..|.....::.|||||              
  Rat   358 DSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLNKY 422

  Fly   258 -----NNEGAHGSGS---PLEVETPLFMWGAGVKRDEIDA-EAN----------FPEKPNISQVD 303
                 |.:..:|..:   |.||....:.:........:.. |.|          .|::.:.::.|
  Rat   423 LGDVNNVKVVYGPAARLRPTEVPETYYSFNYEALAKNLSCRETNQHFRPYLKHFLPKRLHFAKND 487

  Fly   304 QTQLAPLMSSLIGLPPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYK 368
              ::.||...|    .|:..|||.|     ...:|.....| ....|.|..:        |:|..
  Rat   488 --RIEPLTFYL----DPQWQLALNP-----SERKYCGSGFH-GSDNLFSNMQ--------ALFIG 532

  Fly   369 WLPKFKELHIGVIDQ------YAAQFDIL--------KSEGNLTDAME 402
            :.|.||  |...:|.      |....|:|        :|.|:|...::
  Rat   533 YGPAFK--HGAEVDSFENIEVYNLMCDLLGLIPAPNNESHGSLNHLLK 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13978NP_651562.2 GPI_EPT_1 42..328 CDD:293744 69/348 (20%)
PigN 414..839 CDD:282796
Enpp1NP_445987.1 cytoplasmic tail 1..58
transmembrane domain 59..79
SO 86..126 CDD:197571
cysteine-rich domain 87..168
SO 127..170 CDD:197571
catalytic domain 191..573 86/431 (20%)
Phosphodiest 194..520 CDD:366747 70/366 (19%)
Linker. /evidence=ECO:0000250|UniProtKB:P06802 579..628 87/438 (20%)
nuclease-like domain 639..906
NUC 657..888 CDD:214683
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1524
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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