DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and LAS21

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_012473.1	Gene:	LAS21 / 853384	SGDID:	S000003598	Length:	830	Species:	Saccharomyces cerevisiae

Alignment Length:	923	Identity:	191/923 - (20%)
Similarity:	317/923 - (34%)	Gaps:	294/923 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RELGLEPPADRLVVFVTDGLRAATFLANNGSDVPDLKDIYR--QQGRIG--ISRTCAPTMTRPGH 97
            |:|..:.|..:||..:.|.|| :.||.:  |.:....::::  ..|...  .|....||:|.|..
Yeast    43 RDLQRDRPFQKLVFVIIDALR-SDFLFD--SQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRL 104

  Fly    98 IAIFAGFHEDPAASLMHLCYNPG-DFDT-----------VFNRSRNMI--------------GW- 135
            .:|..|    ...|.:.|..|.. |.|:           .|.:..|.|              .|
Yeast   105 KSITTG----STPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWF 165

  Fly   136 -----AHSYIVGYFVKLSHGGAPLRFDSYMERDLPEKLTCDKWAFDKVENFLRNVDNVREWRNYK 195
                 .||:.|..|.::         |:.:.|:||.||                   .:||..:.
Yeast   166 DFADPTHSFFVSDFTQV---------DNNVTRNLPGKL-------------------FQEWAQWD 202

  Fly   196 PAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVFNDSRTAYLMTSDHGMNNE 260
            .|:.. ||. :|...|:..|.||...||.|.....:::.|:......:|..|...:..|||||..
Yeast   203 VAILH-YLG-LDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNEL 265

  Fly   261 GAHGSGSPLEVETPLFMWG---AGVKRDEIDAEANFP--EKPN-----ISQVDQTQLAPLMSSLI 315
            |.||..|..|....|....   |...|.|.......|  ..|:     :..|.|..:.|.:::|.
Yeast   266 GNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALF 330

  Fly   316 GLPPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYKWLPKFKELHIGV 380
            |:|.|.|::.::      :.|          .||||...   :...::...:.|  |..:.|..|
Yeast   331 GMPIPMNSVGII------IPD----------FLQLLPNK---LASMKENFMHLW--KLSDHHGEV 374

  Fly   381 -IDQYAAQFDILKSEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSYMIWFYCLLLQ 444
             :|.:.|: ||            :.|.|  ..::.||.....|..||:....:.::|.....:..
Yeast   375 ALDDFTAE-DI------------YTKMY--TIQETLTKSATNYNYPLLTLAFVGFLIITIIAIYV 424

  Fly   445 LTRLSKKEKMQRRGFMTVSTLILAMIGILL------IAMME------------LQKVP-HIAAFY 490
            |.|.|..:..|.|    ||:|.:.::.|:|      .:.:|            ...|| .:....
Yeast   425 LLRYSGPDFWQLR----VSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIVTAFSAVPLFVYRLN 485

  Fly   491 LILPVGMLIMAQAERPVRGYW-------IF----------HPLWNFGF-ILVPAVLIMS------ 531
            :::.|...||....|.:: :|       |:          :|.|.:.. :|...||||:
Yeast   486 VLIIVRWFIMMACVRSIK-FWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQV 549

  Fly   532 ----MTFIIRHLWVLYGIS-VLLNNRRALRKPSIKLFIWLSLA----------LIVTAILFMEQR 581
                :|.|:..|...|.|| .::|..:|    .|.||:...||          |||.|.:|.:..
Yeast   550 LHFIVTTILVGLCFTYKISWEIVNGNQA----EIPLFMHDLLAKIDFAPTESNLIVLARVFFQAW 610

  Fly   582 TIKGL------------KTIPVKDYHVLYVSMVLAIIRPLILGHRHDPRVWTFNSLTLVVGAFGV 634
            .|..:            |...:||..| |::::|                 .|.:.:..:|.|.|
Yeast   611 AIVVISRLVLTKLKVLNKNYLIKDMKV-YITILL-----------------MFQTSSQNIGQFLV 657

  Fly   635 YQ------YKFYESV-------------SSYVYVVTWSFLFFAF----------LSIVYFAKSLP 670
            :|      :.|::::             |:.|.::..:|.||.|          |...|...|..
Yeast   658 FQILESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSD 722

  Fly   671 EARKRLELITINMITVLSLLTN-----SWGCLNFQI--AITEFIFGLQIYEETKETKEIEDAKDE 728
                    ..|.::.:|..:.|     .|..|.:.|  |.......||.:..:|
Yeast   723 --------YNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSK----------- 768

  Fly   729 HTSLQNLKGF-YR--YGYMILLYFYVSFFLAGHWISSFLFKPTTARLFYPHFSLYIAGSLV--LL 788
                  |..| |.  :|..::....|..|....|           .:|.|....::..:.|  ||
Yeast   769 ------LPAFTYHCIFGTCLMTACVVLRFHLFIW-----------SVFSPKLCYFLGWNFVMGLL 816

  Fly   789 KIFIPSVIFICAL 801
            ..::|.:..:|||
Yeast   817 NGWLPELALLCAL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	76/331 (23%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	98/499 (20%)
LAS21	NP_012473.1	Npp1	18..610	CDD:224441	143/648 (22%)
LAS21	NP_012473.1	GPI_EPT_2	48..343	CDD:293748	76/337 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810