DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13978 and pign

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001297009.1	Gene:	pign / 556797	ZFINID:	ZDB-GENE-080204-114	Length:	932	Species:	Danio rerio

Alignment Length:	957	Identity:	249/957 - (26%)
Similarity:	448/957 - (46%)	Gaps:	155/957 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRAATFLA---NNGSD 68
            |:||::....|.:.||...|:..:.||:    :.|.|||.|||:||.|||||.:...   :..|.
Zfish    11 LIVHVVFFLCIFDIYFTSPLVHGMTPQR----VSLPPPAKRLVLFVADGLRADSLFKPDDSGTSR 71

  Fly    69 VPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFHEDPAASLMHLCYNPGDFDTVFNRSRNMI 133
            .|.|:.:..:.|..|:|.|..||.:||||:|:.|||:||.:|.......||.:||:|||.||...
Zfish    72 APYLRSVIEEGGTWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSVFNESRYTW 136

  Fly   134 GWAHSYIVGYFVK-------LSHGGAPLRFDSYMERDLPEKLTCDKWAFDKVENFL---RNVDNV 188
            .|....|:..|.|       .:|...|.|.| :...|...   .|.|.||:|::||   ::.:.:
Zfish   137 CWGSPDILPMFAKGATGDHVYTHTYPPERED-FASTDASR---LDTWVFDEVKDFLTAAKSNETL 197

  Fly   189 REWRNYKPAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVF-NDSRTAYLMT 252
            .:..:.:..|||::|..:|...|..:|:||:....:.....|:.:...:.:..: :|.:|||:.|
Zfish   198 LKKLHEEQNVFFLHLLGIDTNGHAHRPMSKECLENIGLVDAGVADIVTVMDDFYGHDGKTAYVFT 262

  Fly   253 SDHGMNNEGAHGSGSPLEVETPLFMWGAGVKRDEIDA----EANFPEKPNIS-----QVDQTQLA 308
            |||||.|.|:||:|.|.|..|||.:|||||::.:.:.    |.|:.::..:.     .|:|..:|
Zfish   263 SDHGMTNWGSHGAGHPSETLTPLVVWGAGVQKAQWETSQKYEDNYLKEWGLESYRRVDVNQADIA 327

  Fly   309 PLMSSLIGLPPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKA----IFYKW 369
            ||||||||:|.|.|::.::|:.|||.|..::|.:::.|.:|:|.|..:.:.:.::.    :|..:
Zfish   328 PLMSSLIGIPFPLNSVGVLPLSYLNNSQHFKAESMYANAIQILEQFRVKLAQKKETTISFLFTPY 392

  Fly   370 LPKFKELHIGVIDQYAAQFDILKSEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSY 434
            .|......:..|.|..   |::: :|...:|:.:||:....|.:.|:||:.|.:..|..:..:.:
Zfish   393 QPLTDSKQVDFIRQAR---DLIQ-KGRFDEAIVYCKDLIAQAMEGLSYYHTYDRLFLGSSVVLGF 453

  Fly   435 MIW--FYCLLLQLTRLSKK----------EKMQRRGFMTVSTLILAMIGILLIAMMELQKVPHIA 487
            :.|  :..|.:..|..|.:          |::...||:.|        |:|:...:.:|..|...
Zfish   454 IGWTSYVVLYILKTHASLRKPPTNTSMVTERLLGWGFLCV--------GLLMALFLLVQSSPWSY 510

  Fly   488 AFYLILPVGM-------------LIMAQAERPVR---GYWIFHPLWNFGF-ILVPAVL---IMSM 532
            ..|.::||.:             |:.:....|:.   ||::   |..||. :||.:..   ::|:
Zfish   511 YIYSLMPVAVWYAVLKEFKTLVGLVRSIPSLPLTKCFGYFV---LVAFGIELLVMSFFYRAMLSL 572

  Fly   533 TFIIRHLW-VLYGISVLLNNRRALRKPSIKLFIW----LSLALIVTAILFMEQRTIKGLKTIPV- 591
            ..::..|| |:.|.         ..|...|...|    ||||:               ...:||
Zfish   573 GLVVLALWPVVSGF---------YTKAKFKSLSWTLSCLSLAV---------------FPLLPVV 613

  Fly   592 -KDYHVLYVSMVLAII--------------RPLILGHRHDPRVWTFNSLTLVVGAFGV------Y 635
             ::.::.||.....:|              .||:   |.|.:::.|..:.:.:.|:.:      .
Zfish   614 GREPNINYVISAGGLILFNSSSFLWSSWRDSPLM---RRDRQLFIFQMVQVALCAYTLTSTHSSL 675

  Fly   636 QYKFYESVSSYVYVVTWSFLFFAFLSIVYFAKSLPEARKRLELITINMITVLSLLTN-------- 692
            |.|  :.:..:..:|:||.|..:||..:..:..|   ..||..|.:::..|..||:.
Zfish   676 QLK--QGLPIFNQLVSWSTLVSSFLIPLLSSTRL---FHRLLSILMSLTCVYLLLSTGHEALFPL 735

  Fly   693 --SWGCLNFQIAITEFIFGLQIYEETKETKEIEDAKD-EHTSLQNLK-GFYRYGYMILLYFYVSF 753
              ||..|.: |.|.:.....|......|...|:.|:: :.|.::.|: ...|..|..:.:..::|
Zfish   736 MLSWLMLAW-IHIEQEAMSRQGSSNRNELSCIDFAENIDITKVRQLRLDDIRKSYFFVFFIIIAF 799

  Fly   754 FLAGHWISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIFICALYAMVPFVRKNARSILIS 818
            |..|:..|...|.|.:...|...|:.:|.|.|::.|:.||.||.:|...::....:.::||:.:.
Zfish   800 FGCGNIASINSFDPASVYCFLTVFNPFIMGGLLMWKVLIPFVIVMCTFESIQVSTQLSSRSLFLI 864

  Fly   819 IFMISNAMGLYQYYFIRNRGSWRKIRMFLDQILLTHAVN-FMLLLGI 864
            :.:||:.|.|:.::.:::.|||..|...:...::..::. |::||.:
Zfish   865 VLVISDLMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIFLMLLSV 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	109/308 (35%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	103/495 (21%)
pign	NP_001297009.1	Npp1	11..>282	CDD:224441	95/278 (34%)
		GPI_EPT_1	42..347	CDD:293744	109/308 (35%)
		PigN	433..885	CDD:282796	103/495 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596002
Domainoid	1	1.000	87	1.000	Domainoid score	I8002
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.960