DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and CG5342

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_650088.2	Gene:	CG5342 / 41389	FlyBaseID:	FBgn0037916	Length:	837	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	230/921 - (24%)
Similarity:	405/921 - (43%)	Gaps:	147/921 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRAATFLANNGSDVPD 71
            ::..:||:.|::..|.:.|...:|.||: :..|...||||||||.|.|||.|.:||||..::||.
  Fly     9 VLFQLLLLFAVVLIYLRSTYPGSLEPQE-VEHLKEPPPADRLVVLVRDGLSAQSFLANRCTNVPL 72

  Fly    72 LKDIYRQQGRIGISRTCAPTMTRPG---HIAIFAGFHEDPAASLMHLCYNPGDFDTVFNRSRNMI 133
            |::::..||.:||||  ..|:|...   :|::|:||:||.|:........|...|::|:|.:...
  Fly    73 LRELFLHQGLVGISR--PETITYHSISPYISLFSGFNEDAASVARGWLGTPASIDSIFDRCKRSF 135

  Fly   134 GWAHSYIVGYFVKLSHGGAPLRFDSYMERDLPEKLTCDKWAFDKVENFLRNVDNVREWRNYKPAV 198
            .|..:.::..|.|:.. ...|.|::|.|.........:.:....|:.||..  ..|...|....:
  Fly   136 AWTTTELISRFPKIER-PRELSFETYGEGVTKSCSEMEDFVCRSVQRFLGG--GSRLLLNTTGVI 197

  Fly   199 FFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVFNDSRTAYLMTSDHGMNNEGAH 263
            ||:::..::.:..           .||..|..:.|.|:.||:.|.|.|||||.||:.|   :...
  Fly   198 FFIHMTGVEPSCE-----------SLQRIQENVWNVYKSFEKTFPDQRTAYLFTSNLG---DPQT 248

  Fly   264 GSGSPLEVETPLFMWGAGVK-------RDEIDAEANFPEKPNISQVDQTQLAPLMSSLIGLPPPK 321
            .|...|.||:|.|:||:||.       |..:..||..  :..:..::...|..|||:|:|:|||.
  Fly   249 KSEYSLAVESPFFLWGSGVNHIKSMPGRSFMANEAGL--RLPLHVLNTPHLTALMSALLGVPPPV 311

  Fly   322 NNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYKWLPKFKELHIGVIDQYAA 386
            .:..::|.|.||.|..|:|.|:.:|..|||:||..|...|.|.:...|| .|:     ::|.:..
  Fly   312 YSRGMLPKGMLNASLRYEANAMLINAKQLLAQARRLRELHPKRMPAFWL-SFQ-----MMDNFVK 370

  Fly   387 QFDILKSEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSYMIWFYCLLLQLT----- 446
            :...||.:......:::...|..:..|.:.|:..||:...|.|.|.:.:.|.|||...||
  Fly   371 ESLALKKQRRFRALLDYSCNYMPVLIKGMDYFKDYYRHVSITAVSFAGIAWIYCLRCHLTVGKKC 435

  Fly   447 --------RLSKKEKMQRRGFMTVSTLILAMIGILLIAMMELQKVPHIAAFYLILP-----VGML 498
                    .:|.|..:..|||..:.|      |:|:|.|| |:::|.:....|::|     ..:.
  Fly   436 RNLIEIQEVISSKRLVYARGFHRLLT------GVLVIIMM-LERIPLVVQAILLIPSLYWRTTLK 493

  Fly   499 IMAQAERPVRGYWIFHPLWNFGFILVPAVLIMSMT---------FIIRH-LWVLYGISVLLNNRR 553
            |:  .|||.               :|....:||..         |..|: |.|.|......|||.
  Fly   494 IL--GERPK---------------MVCRKSLMSTALLALICFGGFFRRYILAVGYLGFASYNNRE 541

  Fly   554 ALRKPSIKLFIWLSLALIVTAILFMEQRTIKGLKTIPVKDYHVLYVSMVLAIIRPLILGHRHDPR 618
            |.::...:.::||.|.|.:|.:..:.:       ::.......|..|:.|.::|||..|...:..
  Fly   542 AFKRRGHQFYLWLLLLLGLTVVSALPE-------SLGCSQPGALMFSIFLTVLRPLACGVYLNLL 599

  Fly   619 VWTFNSLTLVVGAFGVYQYKFYESVSSYVYVVTWSFLFFAFLSIVYFAKSLPEARKRLELITINM 683
            .|..| :.:::.|.......::..:   :|:|:|.:|.|.   :::..::|..:    |:...::
  Fly   600 TWLSN-IPVLLAALEYILIGWHPWI---MYLVSWIYLGFL---VLWQRRNLQAS----EVFFFDL 653

  Fly   684 ITVLSLLTNSWGCLNFQIAITEFIFGLQIYEETKETKEIEDAKDEHTSLQNLKGFYRYGYMILLY 748
            .|:.:|...|:..:..|:...|....|::  :.|..:.|......|              .||:|
  Fly   654 STLYTLTCTSYESVVIQMLAMELQLALRM--KLKRNESIGPKTAAH--------------YILVY 702

  Fly   749 FYVSFFLAGHW--ISSFL---------FKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIFICALY 802
            .:.|.|:.|.:  ...||         :.|.|            .|.:::||:.:|.::.:|.:.
  Fly   703 SWYSLFIIGSFPAFDDFLDILHETCFGYSPLT------------YGLVMVLKLILPWLLVLCIMA 755

  Fly   803 AMVPFVRKNARSILISIFMISNAMGLYQYYFIRNRGSWRKIRMFLDQILLTHAVNFMLLLGISLA 867
            .....:....:.|.:.:.::::||.|...:.|.|.|.||.|.....:..:.|....:.||...|.
  Fly   756 GNYKSLASYEQQIFVRLLLMNSAMSLVLLHGITNVGPWRDILSRFAEFAVVHVFPLVWLLLWRLT 820

  Fly   868 KIFLANTTMER 878
            ::.:.:..|.:
  Fly   821 QLKVGSKWMSQ 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	92/295 (31%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	95/463 (21%)
CG5342	NP_650088.2	GPI_EPT_1	43..318	CDD:293744	92/295 (31%)
CG5342	NP_650088.2	PigN	398..781	CDD:282796	92/452 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470303
Domainoid	1	1.000	69	1.000	Domainoid score	I2673
eggNOG	1	0.900	-	-		E1_COG1524
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	1	1.000	-	-		FOG0014321
OrthoInspector	1	1.000	-	-		otm47052
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.800