DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and CG6790

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_650087.2	Gene:	CG6790 / 41388	FlyBaseID:	FBgn0037915	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	885	Identity:	319/885 - (36%)
Similarity:	492/885 - (55%)	Gaps:	59/885 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWKLQALVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRAATFLANN 65
            :||.:.::||:||:..|:..::|...|..|.||||:.::|:.|.|||||||:.:||||.|..::|
  Fly    42 LWKSKVVLVHLLLLICIMRIFYQSGPLSQLEPQKTLLDMGVPPAADRLVVFLLEGLRADTLFSDN 106

  Fly    66 GSDVPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFHEDPAASLMHLCYNPGDFDTVFNRSR 130
            .|....::||..:||.:|||:|..||:||...:|:||||  :|..|::    ...:|||:|||:.
  Fly   107 CSGAVYIRDIILRQGLVGISKTSVPTLTRSAEVALFAGF--NPMPSIL----PTSNFDTIFNRTL 165

  Fly   131 NMIGWAHSYIVGYFVKLSHGGAPLRFDSYMERDLPEKLTCDK-WAFDKVENFLRNVDNVREWRNY 194
                   ::..|.|::.||       .|.:.|.|.::...:| |..:|:
  Fly   166 -------AFDKGAFLRFSH-------LSDLRRRLTKRACLEKLWYANKL---------------- 200

  Fly   195 KPAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVFNDSRTAYLMTSDHGMNN 259
               |..|.||::..|:    ||...|..||..|||.||:.|||.|..||||:||||.||.||:..
  Fly   201 ---VMLVNLAEVGGAS----PLDIGFQMKLHNTQRNIRDAYELIEATFNDSKTAYLYTSAHGLTY 258

  Fly   260 EGAHGSGSPLEVETPLFMWGAGVKRDEIDAEANFPEKPNIS----QVDQTQLAPLMSSLIGLPPP 320
            .|:||.||..|.|.|..:||||||....:..::|.....:.    ::||.|||||||:|||||||
  Fly   259 FGSHGGGSDEEREAPFLLWGAGVKHVTENITSDFVLNNGVGMQLHKLDQIQLAPLMSALIGLPPP 323

  Fly   321 KNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYKWLPKFKELHIGVIDQYA 385
            .||||::|.||:.||.||...::|||.||||:||:.:|..||:.:|:|||||.|:|.:..|..|.
  Fly   324 VNNLAILPQGYMKVSREYARKSVHLNALQLLTQAKAIIRLHERGVFHKWLPKDKDLDLQQIAYYQ 388

  Fly   386 AQFDILKSEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSYMIWFYCLLLQLTRLSK 450
            .|.|.|...|..:.|:|......|:|.|.|.:|:.||..||:|...::.:.|.:..|::|::...
  Fly   389 NQMDHLLDMGWRSKALETSTLAIKVALKSLKFYHNYYHIPLVVTTVLALLGWQFYQLVKLSQNVM 453

  Fly   451 KEKMQRRGFMTVSTLILAMIGILLIAMMELQKVPHIAAFYLILPVGMLIMAQAERPVRGYWIFHP 515
            .....|||::|..|:.||.:|:||..|:.||..|.:....|::|.|:..|..|..|..|.|||.|
  Fly   454 APHYMRRGYLTWCTIFLASLGLLLGEMVFLQWAPFMTVICLVVPFGVWCMTLAALPQNGGWIFEP 518

  Fly   516 LWNFGFILVPAVLIMSMTFIIRHLWVLYGISVLLNNRRALRKPSIKLFIWLSLALIVTAILFMEQ 580
            |.:..:|:.||.::::..:....|.:.|.:.|...|||....||.|...||:|.|::...|:.:
  Fly   519 LKHLRWIVGPAAVMIASIYCNCPLSLAYILCVGFYNRRGWLHPSPKFLAWLALVLLLGGFLWSQ- 582

  Fly   581 RTIKGLKTIPVKDYHVLY--VSMVLAIIRPLILGHRHDPRVWTFNSLTLVVGAFGVYQYKFYESV 643
               ||::.:...:|.|:.  :||::.|:||.:|...|..:||..|...|.|.|.|::..:..:.|
  Fly   583 ---KGMQILMTTNYRVVLQAISMLVVIVRPCVLNENHKWKVWVINGGILFVAAIGIFLKEMGKPV 644

  Fly   644 SSYVYVVTWSFLFFAFLSIVYFAKSLPEARKRLELITINMITVLSLLTNSWGCLNFQIAITEFIF 708
            ..|::...|::|.:||.|:...:::.|::  |||||..|::|:..||::|:..|..|..|.|:..
  Fly   645 PLYLFAANWAYLIYAFASVPCSSRTTPQS--RLELIRFNLLTLHVLLSDSYVSLFAQGLIIEYQM 707

  Fly   709 GLQIYEETKETKEIEDAKDEHTSLQNLKGFYRYGYMILLYFYVSFFLAGHWISSFLFKPTTARLF 773
            ||:::|:.||..  ||.| ..||.::|:..||:...||||||.|.|..|||:..|.:...:||||
  Fly   708 GLEVHEKFKEAD--EDVK-ILTSSKHLQMCYRFAVSILLYFYASLFGTGHWVGGFTYLANSARLF 769

  Fly   774 YPHFSLYIAGSLVLLKIFIPSVIFICALYAMVPFVRKNARSILISIFMISNAMGLYQYYFIRNRG 838
            .|..|..:...|||:.:.|||::.:.::.|:..|.|:..|:|..|:.:|.||:.|:...|:.:..
  Fly   770 LPDSSSGLVPLLVLIHLLIPSIVIMASVVALSSFGRQQIRTIFSSLMLICNAVVLFFVVFVPHNA 834

  Fly   839 SWRKIRMFLDQILLTHAVNFMLLLGISLAKIFLANTTMER 878
            .|......:...||......::|...|:..||.....|.|
  Fly   835 YWPMAHPSVVHALLAQLTVILILACESIVTIFFRRLNMNR 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	116/290 (40%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	141/426 (33%)
CG6790	NP_650087.2	GPI_EPT_1	83..331	CDD:293744	116/290 (40%)
CG6790	NP_650087.2	PigN	418..821	CDD:282796	137/411 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470300
Domainoid	1	1.000	69	1.000	Domainoid score	I2673
eggNOG	1	0.900	-	-		E1_COG1524
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	1	1.000	-	-		FOG0014321
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800