DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and PIG-O

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster

Alignment Length:	1132	Identity:	209/1132 - (18%)
Similarity:	365/1132 - (32%)	Gaps:	439/1132 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLMGAILNTYFQH-TLLPNL-VPQKTMRELGLEPPADRLVVFVTDGLR--AATFLANNGSDVP-- 70
            :|...::|..|:. ....|| :|||:           :::|.|.|.|:  ...:.||....:|
  Fly    52 VLTDEVVNEIFKDVNASSNLCLPQKS-----------KVIVLVVDALKYEFGLYRANATDPLPYE 105

  Fly    71 ----DLKDIYRQ---QGRIGISRTCAPTMT-----------RPGHIAIFAGF-----HEDPAASL 112
                .|:::.:|   ..|:...|...||.|           .|..|.|.:.|     :||..  :
  Fly   106 NKLVVLQELLQQNPDHARLMRFRADPPTTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNI--I 168

  Fly   113 MHLCYNPGDFDTVFNRSRNMIG---WAHSYIVGYFVKLSHGGAPLRFD---SYMERDLPEKLTCD 171
            ..:..|  |...||      :|   |...|             |.||.   ||...|:
  Fly   169 DQIVKN--DLPVVF------LGDSTWTDLY-------------PHRFKRSYSYPSFDI------- 205

  Fly   172 KWAFDKVEN-FLRNVDNVREWRNYKPAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTY 235
             :..|.|:| .|:::....|.::::  |...:...:|...|:..|:.::...||......||:..
  Fly   206 -FDLDSVDNEILKHLPKELESKDWQ--VLVAHFLGVDHCGHKHGPMHEEMARKLGEMNEVIRSVV 267

  Fly   236 ELFERVFNDSRTAYLMTSDHGMNNEGAHGSGSPLEVETPLFMWGAGVKRDEIDAEANFPEKPNIS 300
            ...     |:.|..|:..||||...|.||..:..|....||.:.   |:.......:..:...:.
  Fly   268 AAM-----DNDTTLLVMGDHGMTASGDHGGDTDDETNALLFAYS---KQHRFYGNDSGSDSEMLQ 324

  Fly   301 QVDQTQLAPLMSSLIGLPPPKNNLAL--------MPVGYLNVSDEYQAVALH------------- 344
            |:|   |.|.:::::|:|.|.:||.|        :.|.:||   ::|.:.||
  Fly   325 QID---LVPTLATILGVPIPYSNLGLVNFNIVPDLRVPHLN---KFQTLLLHSWQNAQQIYRYFF 383

  Fly   345 ---------LNVLQL-LSQAEILIGRHE------------------------------------- 362
                     .||.|: ..:.|.::..|.
  Fly   384 QYALENKRTFNVEQMDHLETEFILLTHRVQTVYNEVAFKSFVRDLNTNLRDILGTCREIWVRFDP 448

  Fly   363 -----------------------------------KAIFYKWLP---------------KFKELH 377
                                               |.:||.:|.               .||...
  Fly   449 TQMSQGLLFTFLPLFFIFLVVNNSRPADFPHIFKAKEVFYVYLINLAAGVFGYRYFKTFSFKTEE 513

  Fly   378 IGVI------DQYAAQFDILKSEGNLTDAMEFCKEYGKLAKKCLTYYNQ--YYQTPLIV--ANSM 432
            .|||      ......|..|:...::.......|.:|.:..:.|.:.:.  ::....::  |..:
  Fly   514 QGVIFFTAISSAVILAFHTLRHWTSIATNWSAVKRFGHMPTRLLLFGSMAVFFSNSFVIQEAKIL 578

  Fly   433 SYMIWFYCLLL--QLTRLSK----KEKMQRRGFMTVSTLILAMIGILLIAMMELQ---------- 481
            ||::....|||  :|.|||.    :.|.:...|:..:.|.|.:..:|.|.::...
  Fly   579 SYLLAAAILLLSHELLRLSARLDFRTKFKASQFLRSTALRLILASVLAICLIRFAYTLFRCREEQ 643

  Fly   482 ----------------KVPHIAAFYLILPVGMLIMAQAERPVRGYWIFHPLWNFGFIL--VPAVL 528
                            |.|.....|::..|.:::.....|..        |.:.|.:.  :|.||
  Fly   644 GNCSDFVNTGGAGFSLKKPGTGKTYILAVVVLVVYTTLTRLY--------LRSCGNLTGNLPNVL 700

  Fly   529 ----------------IMSMTFIIRHL---------WVLYGISVLLNNRRALRKPSIKLFIWLSL 568
                            |:.....|:|:         .|:||:.::             ..|.||.
  Fly   701 LARYGPTVASICAGGHILLANSSIKHIQRTHIDAMALVIYGLLLV-------------QIIVLSW 752

  Fly   569 ALIVTAILFMEQRTIKGLKTIPVKDYHVLYV----SMVLAIIRPLILGHR--------HDPRVWT 621
            |.::|.:|             |.:..|.:.:    |:|..|.|.:...:.        |.|.|:.
  Fly   753 APLMTFVL-------------PPRSSHTVTINGNESIVPEIFRKMKRMYEGDDDERRSHIPVVYG 804

  Fly   622 FNSL-TLVVGAFGVYQYKFYESVSSYVYVVTWSFLFFAFLSIVYFAKSLPEARKRLELITINMIT 685
            ..:: :.:|.||||                     |.|.:.||     |.|.|..:.|:.  .:.
  Fly   805 LATVYSSIVIAFGV---------------------FLALVMIV-----LLEPRASIGLVV--CVA 841

  Fly   686 VLSLLTNSWGCLNFQIAITEFIFGLQIYEETKETKEIEDAKDEHTSLQNLKGFYRYGYMILLYFY 750
            |.::|.:....|.::.| |.|...:|               ...|:|        .|:.:|.:|
  Fly   842 VGAILLSVHSILRYRTA-TSFESCVQ---------------PTFTAL--------VGWFLLAHF- 881

  Fly   751 VSFFLAGH--------WISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIFIC-------- 799
             .||...|        |.::|:.:.|....     |..::|:||:|..|...:.|.|
  Fly   882 -CFFATSHQTTLSQIEWRAAFVGRTTGIGQ-----SNLVSGALVILNTFCGPIFFFCMYSLLSTE 940

  Fly   800 --ALYAMVPFVRKNARS---------------ILISIFMISNAMGLYQY--YFIRNRGSWRKIRM 845
              :|:|:.|.:.::.||               ..:...|....:.||:|  .|:   |:..|:
  Fly   941 TFSLFALFPNLIRSCRSGGKVDASTSMSDLANEAVGFDMTRGELSLYEYEDVFL---GTGFKL-- 1000

  Fly   846 FLDQILLTHAVNFMLLLGISLAKIFLA 872
                     |..|.:|.|:   |||.|
  Fly  1001 ---------ATQFFMLQGL---KIFCA 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	70/327 (21%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	97/535 (18%)
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	73/329 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810