DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and Pign

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_038946765.1	Gene:	Pign / 309051	RGDID:	1311346	Length:	939	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	242/968 - (25%)
Similarity:	440/968 - (45%)	Gaps:	163/968 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRAATF--LANNG-SD 68
            |:||.:...:|.:.||...|:..:.||.|    .|.|||.|||:||.|||||...  |..:| |.
  Rat     9 LLVHFVFFASIFDIYFTSPLVHGMTPQVT----PLPPPAKRLVLFVADGLRADALYELDEDGNSR 69

  Fly    69 VPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFHEDPAASLMHLCYNPGDFDTVFNRSRNMI 133
            .|.::::...:|..|:|.|..||.:||||:|:.|||:||.:|.......||.:||::||.|:...
  Rat    70 APFIRNVIMHEGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTW 134

  Fly   134 GWAHSYIVGYFVKLSHGGAPLRFDSYMERD---LPEKLTCDKWAFDKVENFL---RNVDNVREWR 192
            .|....|:..|.|.:.|.....:....:|:   ..:....|.|.||||::|.   ||..::....
  Rat   135 SWGSPDILPMFAKGASGDHVYTYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFSIV 199

  Fly   193 NYKPAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVF-NDSRTAYLMTSDHG 256
            |.:..|||::|..:|...|..:|.|:::...::....|::....:|:..: :|.:||::.|||||
  Rat   200 NEEKVVFFLHLLGIDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYEDDGKTAFIFTSDHG 264

  Fly   257 MNNEGAHGSGSPLEVETPLFMWGAGVKRDEIDAEANFPEKPNISQ------------------VD 303
            |.:.|:||:|.|.|..||...||||:|         ||:..:..|                  ::
  Rat   265 MTDWGSHGAGHPSETLTPFVTWGAGIK---------FPQNVSAQQYEDEFLKEWRLENWKRQDIN 320

  Fly   304 QTQLAPLMSSLIGLPPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYK 368
            |..:||||:||||:|.|.|::.::||||||.:..::|.::..|.:|:|.|.::.:.:.::|....
  Rat   321 QADIAPLMASLIGVPFPLNSVGILPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKEATLPF 385

  Fly   369 WLPKFKELHIGVIDQYAAQFDILK------SEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLI 427
            ....||.|      ..:.|.|||:      .:....|.:..|:|...||.:.|:||:.|.:..|.
  Rat   386 LFTPFKLL------SDSQQLDILRKARSYIKQEKFDDVVSLCEELIDLALRGLSYYHTYDRLFLG 444

  Fly   428 VANSMSYMIW-FYCLLL------QLTRLSKKEKMQRRGFMTVSTLILAMIGILLIAMMELQKVPH 485
            ::.::.::.| .|..||      .:.|.:::|..:....:..|.::   .|:|:...:.:|..|.
  Rat   445 ISVAVGFVGWTSYASLLIIKSHSDIPRGTRREGKKPHHLLPCSFIV---AGVLVACFLMIQACPW 506

  Fly   486 IAAFYLILPVGMLIMAQAERP-----VRGYWIFHPLWNF-GFILV--PAVLIMSMTFIIRHL--- 539
            ....|.:|||.:......||.     |.....| ||..| .::||  ..:.::.::|..|::
  Rat   507 TYYVYCLLPVPIWYAVLKEREVIQALVESLLAF-PLSRFVAYLLVFTLGIEVLVLSFFYRYMLTA 570

  Fly   540 ------------------------WVLYGISVLLNNRRAL--RKPSIKLFIWLSLALIVTAILFM 578
                                    |..:.:.:.:.....:  |||.:.|.:...|.:::.::..:
  Rat   571 GLIVFAGWPFLTQLWTRAKITCLSWAFFSLLLAVFPLMPVVGRKPDLSLVMGAGLLVLLLSLAVL 635

  Fly   579 EQRTIKGLKTIPVKDYHVLYVSMVLAIIRPLILGHRHDPRVWTFNSLTLVVGAFGVYQYKFYESV 643
              .|:...|...|||..::.:..||:.:..:.:.:.      |.:||....|...:.|
  Rat   636 --ATLVKRKLNLVKDELLVLLLQVLSTVLSMYVVYS------THHSLLKKEGLPLLNQ------- 685

  Fly   644 SSYVYVVTWSFLFFAFLSIVYFAKSL------PEAR-KRLELITINMITVLSLLTNSWGCLNFQI 701
                 :|:|:.|          |.||      |.|. :||..|.:::::...||:..:..| |.:
  Rat   686 -----IVSWATL----------ASSLVVPLLSPTALWQRLTSILLSLMSTYLLLSTGYEAL-FPL 734

  Fly   702 AITEFIF-GLQIYEETKETKEIEDAKDEHTSLQ-----NLKGF-------YRYGYMILLYFYVSF 753
            .::..:| .:.:.:||.:...: ..|.:..|:|     ::..|       .|..:.::.:...:|
  Rat   735 VLSCLMFVWIHVEQETLQQSGV-SCKQKLASIQFTYNTDITQFRQLCLDDIRRAFFLVFFLLTAF 798

  Fly   754 FLAGHWISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIFICALYAMVPFVRKNARSILIS 818
            |..|:..|...|...:...|...||.::.|:|::.||.||.|:.:||..|:....:.:::.|..|
  Rat   799 FGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQITTQLSSKGIFSS 863

  Fly   819 IFMISNAMGLYQYYFIRNRGSWRKIRMFLDQIL-----LTHAVNFMLLLGISLAKIFL 871
            ...|. |.||...........|.: ||...|:.     ::|   :::::.:::..:||
  Rat   864 WSRIL-AAGLILEQVRSGLVKWDR-RMLQKQVCSRKSSISH---YVIVMSMTIFLVFL 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	104/313 (33%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	96/488 (20%)
Pign	XP_038946765.1	GPI_EPT_1	40..345	CDD:293744	104/313 (33%)
Pign	XP_038946765.1	PigN	431..861	CDD:398585	90/465 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353834
Domainoid	1	1.000	98	1.000	Domainoid score	I7041
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.820