DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and Pign

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_038812.2	Gene:	Pign / 27392	MGIID:	1351629	Length:	931	Species:	Mus musculus

Alignment Length:	966	Identity:	249/966 - (25%)
Similarity:	451/966 - (46%)	Gaps:	167/966 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRAATF--LANNG-SD 68
            |::|.:...:|.:.||...|:..:.||.|    .|.|||.|||:||.|||||.|.  |..:| |.
Mouse     9 LLIHFVFFASIFDIYFTSPLVHGMTPQFT----PLPPPAKRLVLFVADGLRADTLYELDEDGNSR 69

  Fly    69 VPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFHEDPAASLMHLCYNPGDFDTVFNRSRNMI 133
            .|.::::...:|..|:|.|..||.:||||:|:.|||:||.:|.......||.:||::||.|:...
Mouse    70 APFIRNVIMHEGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTW 134

  Fly   134 GWAHSYIVGYFVKLSHGGAPLRFDSYMERD---LPEKLTCDKWAFDKVENFL---RNVDNVREWR 192
            .|....|:..|.|.:.|.....:....:|:   ..:....|.|.||||::|.   ||..::....
Mouse   135 SWGSPDILPMFAKGASGDHVYTYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKV 199

  Fly   193 NYKPAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVF-NDSRTAYLMTSDHG 256
            |.:..|||::|..:|...|..:|.|:::...::....|::....:|:..: :|.:||::.|||||
Mouse   200 NEEKVVFFLHLLGIDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHG 264

  Fly   257 MNNEGAHGSGSPLEVETPLFMWGAGVKRDEIDAEANFPEKPNISQ------------------VD 303
            |.:.|:||:|.|.|..||...||||:|         ||:..:..|                  |:
Mouse   265 MTDWGSHGAGHPSETLTPFVTWGAGIK---------FPQNVSAQQYDDEFLKEWRLENWKRRDVN 320

  Fly   304 QTQLAPLMSSLIGLPPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYK 368
            |..:||||:||||:|.|.|::.::||||||.:..::|.::..|.:|:|.|.::.:.:.::|....
Mouse   321 QADIAPLMASLIGVPFPLNSVGILPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKEATLPF 385

  Fly   369 WLPKFKELHIGVIDQYAAQFDILK------SEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLI 427
            ....||.|      ..:.|.|||:      .:....:.:..|:|...||.:.|:||:.|.:..|.
Mouse   386 LFTPFKLL------SDSQQLDILRKARSYIKQEKFDEVVSLCEELIDLALRGLSYYHTYDRLFLG 444

  Fly   428 VANSMSYMIWF-YCLLLQLTRLSKKEKMQRR-GFMTVSTLILAMI--GILLIAMMELQKVPHIAA 488
            :..::.::.|. |..||.:...|...|..|: |......|:.:.|  |:|:...:.:|..|....
Mouse   445 INVAVGFVGWMSYTSLLIIKSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYY 509

  Fly   489 FYLILPVGMLIMAQAERPV------------RGYWIFHPLWNFGFILVPAVLIMSMTF------- 534
            .|.:|||.:......|..|            |.:::.:.|   .|.|...||::|..:
Mouse   510 VYCLLPVPIWYAVLREHEVIQDLVESLLTFPRSHFVAYLL---VFTLGIEVLVLSFFYRYMLTAG 571

  Fly   535 --------IIRHLWVLYGI--------SVLLNNRRAL--------RKPSIK-------LFIWLSL 568
                    .:..||....|        |:||    |:        |||::.       |.:.|||
Mouse   572 LIVFAGWPFLTQLWTRAKITFLSWAFFSLLL----AVFPLMPVVGRKPNLSLVMGAGFLVLLLSL 632

  Fly   569 ALIVTAILFMEQRTIKGLKTIPVKDYHVLYVSMVLAIIRPLILGHRHDPRVWTFNSLTLVVGAFG 633
            |::.|    :.:|.||.:|    .:..||.:.|:..::...::...|       :||....|...
Mouse   633 AVVTT----LGKRNIKLVK----GELLVLLLQMLSTVLSMYVVYSTH-------HSLLKKEGLPL 682

  Fly   634 VYQYKFYESVSSYVYVVTWSFLFFAFLSIVYFAKSLPEARKRLELITINMITVLSLLTNSWGCLN 698
            :.|            :|:|:.|..:.::.:..:.:|.:   ||..|.:::::...||:..:..|
Mouse   683 MNQ------------IVSWATLASSLVAPLLSSTALSQ---RLASILLSLMSTYLLLSTGYEAL- 731

  Fly   699 FQIAITEFIF-GLQIYEETKETKEIEDAKDEHTSLQ-----NLKGF-------YRYGYMILLYFY 750
            |.:.::..:| .:|:.:||.:...: ..|.:.||:|     ::..|       .|..:.::.:..
Mouse   732 FPLVLSCLMFVWIQVEQETLQQPGV-SCKQKLTSIQFTCDTDIAQFRQLCPDDIRRAFFLVFFLL 795

  Fly   751 VSFFLAGHWISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIFICALYAMVPFVRKNARSI 815
            .:||..|:..|...|...:...|...||.::.|:|::.||.||.|:.:||..|:....:.:::.:
Mouse   796 TAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQITTQLSSKGL 860

  Fly   816 LISIFMISNAMGLYQYYFIRNRGSWRKIRMFLDQILLTHAVNFMLLLGISLAKIFL 871
            .:.:.:||:.|.|:.::.:::.|||..|.        |...::::::.:::..:||
Mouse   861 FLVVLIISDIMALHFFFLVKDSGSWLDIG--------TSISHYVIVMSMTIFLVFL 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	106/313 (34%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	103/491 (21%)
Pign	NP_038812.2	GPI_EPT_1	40..345	CDD:293744	106/313 (34%)
Pign	NP_038812.2	PigN	431..884	CDD:368221	103/491 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850139
Domainoid	1	1.000	99	1.000	Domainoid score	I7107
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.810