DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and PIGN

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_011524191.1	Gene:	PIGN / 23556	HGNCID:	8967	Length:	970	Species:	Homo sapiens

Alignment Length:	1000	Identity:	252/1000 - (25%)
Similarity:	449/1000 - (44%)	Gaps:	196/1000 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRAATF--LANNG-SD 68
            |::|.:...:|.:.||...|:..:.||.|    .|.|||.|||:||.|||||...  |..|| |.
Human     9 LLIHFVFFASIFDIYFTSPLVHGMTPQFT----PLPPPARRLVLFVADGLRADALYELDENGNSR 69

  Fly    69 VPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFHEDPAASLMHLCYNPGDFDTVFNRSRNMI 133
            .|.:::|...:|..|||.|..||.:||||:|:.|||:||.:|.......||.:||::||.|:...
Human    70 APFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTW 134

  Fly   134 GWAHSYIVGYFVKLSHGGAPLRFDSYMERD---LPEKLTCDKWAFDKVENFL---RNVDNVREWR 192
            .|....|:..|.|.:.|.....:....:|:   ..:....|.|.||.|::|.   ||..::....
Human   135 SWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKI 199

  Fly   193 NYKPAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVF-NDSRTAYLMTSDHG 256
            |.:..|||::|..:|...|..:|.|:.:...::....|::....:|...: ||.:|.::.|||||
Human   200 NEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHG 264

  Fly   257 MNNEGAHGSGSPLEVETPLFMWGAGVKRDEIDAEANFPEKPNISQ------------------VD 303
            |.:.|:||:|.|.|..|||..||||:|         :|::.:..|                  |:
Human   265 MTDWGSHGAGHPSETLTPLVTWGAGIK---------YPQRVSAQQFDDAFLKEWRLENWKRLDVN 320

  Fly   304 QTQLAPLMSSLIGLPPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEI-LIGRHEKAIFY 367
            |..:||||:||||:|.|.|::.::||.|||.:|.::|.::..|.:|:|.|.:: :..:.|..:.:
Human   321 QADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPF 385

  Fly   368 KWLPKFKELHIGVIDQYAAQFDILK------SEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPL 426
            .:.| ||.|      ..:.||:||:      ......:.:..|||...||.|.|:||:.|.:..|
Human   386 LFTP-FKLL------SDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFL 443

  Fly   427 IVANSMSYMIWF-YCLLLQLTRLSKKEKMQRRGFMTVSTLI---LAMIGILLIAMMELQKVPHIA 487
            .|...:.::.|. |..||.:...|...|...:.....|.|:   ...||||:...:.:|..|...
Human   444 GVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTY 508

  Fly   488 AFYLILPV----GMLIMAQAERPVRGYWIFHPLWNF-GFIL--VPAVLIMSMTFIIRHL------ 539
            ..|.:||:    .:|...|..:.:....:.:||.:| |::|  ...:.::.::|..|::
Human   509 YVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLT 573

  Fly   540 ---------------------WVLYGISVLLNNRRAL--RKPSIKLFIWLSLAL------IVTAI 575
                                 |..:.:.:.:.....:  |||.|.|.:...|.:      :||::
Human   574 AFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSL 638

  Fly   576 LFMEQRTIKGLKTIPVKDYHVLYV-SMVLAIIRPLILGHRHDPRVWTFNSLTLVVGAFGVYQYKF 639
            :..:...||....:     |:|.| |.||::                               |..
Human   639 MKRKDSFIKEELLV-----HLLQVLSTVLSM-------------------------------YVV 667

  Fly   640 YESVSSYV---------YVVTWSFLFFAFLSIVYFAKSLPEARKRLELITINMITVLSLLTNSWG 695
            |.:.||.:         .:::|:.|   ..|:|....|.|...:||..|.:::::...||:..:.
Human   668 YSTQSSLLRKQGLPLMNQIISWATL---ASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYE 729

  Fly   696 CLNFQIAITEFIF-GLQIYEETKETKEIEDAKDEHTSLQ--------NLKGFY----RYGYMILL 747
            .| |.:.::..:| .:.|.:||.:...: ..|.:.||:|        ..:..|    |..:.::.
Human   730 AL-FPLVLSCLMFVWINIEQETLQQSGV-CCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVF 792

  Fly   748 YFYVSFFLAGHWISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIFICALYAMVPFVRKNA 812
            :...:||..|:..|...|...:...|...||.::.|:|::.||.||.|:.:||..|:....:.::
Human   793 FLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSS 857

  Fly   813 RSILISIFMISNAMGLYQYYFIRNRGSW-----------------------RKIRMFLD---QIL 851
            :|:.:.:.:||:.|.|:.::.:::.|||                       .::.|..|   .:.
Human   858 KSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTRQLLACTAWLFMYISASPNRLWMLSDPGLDLN 922

  Fly   852 LTHAV-----NFMLLLGISLAKIFL 871
            |.||:     ::::::.:::..:||
Human   923 LLHAIRACISHYVIVMSMTIFLVFL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	107/313 (34%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	99/493 (20%)
PIGN	XP_011524191.1	Npp1	7..>280	CDD:224441	94/274 (34%)
		GPI_EPT_1	40..345	CDD:293744	107/313 (34%)
		PigN	431..884	CDD:282796	99/493 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159769
Domainoid	1	1.000	100	1.000	Domainoid score	I7061
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.910