DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and Pigg

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_003751363.1	Gene:	Pigg / 100910143	RGDID:	1560335	Length:	986	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	201/983 - (20%)
Similarity:	324/983 - (32%)	Gaps:	344/983 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPA-------------------DRLVVF 51
            |..|.|.::|..:   |.....|..|......|.|.|.||                   .::|:.
  Rat    10 ASCVAIEVIGVAI---FIRGFFPAPVRSSARPEHGAETPAPEPVAGVSSNWTKLPPPLFSKVVIM 71

  Fly    52 VTDGLR--------------AATFLANNG---SDVPDLKDIYRQQGRIGISRTCAPTMTRPGHIA 99
            :.|.||              ..|:|...|   |.|.:.|               .||:|.|...|
  Rat    72 LIDALRDDFVFGSKGVKYMPYTTYLVEKGASHSFVAEAK---------------PPTVTMPRIKA 121

  Fly   100 IFAGFHEDPAASLMHLCYNPGDFDTVFNRSR------NMIGWAHS---YIVGY----FVKL---- 147
            :..|       ||      ||..|.:.|.:.      |:|..|.:   .|:.|    :|||
  Rat   122 LMTG-------SL------PGFVDVIRNLNSPVLLEDNVIRQAKAAGKRIIFYGDETWVKLFPKH 173

  Fly   148 --SHGGAPLRFDS-YMERDLPEKLTCDKWAFDKVENFLRNVDNV---REWRNYKPAVFFVYLADM 206
              .:.|....|.| |:|.|               .|..|::|.|   .:|     .|..::...:
  Rat   174 FVEYDGTTSFFVSDYIEVD---------------NNVTRHLDKVLRRGDW-----DVLILHYLGL 218

  Fly   207 DIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVFNDSRTAYL-----MTSDHGMNNEGAHGSG 266
            |...|...|.|.....||......:   .::...:.:..|...|     :..||||:..|:||:.
  Rat   219 DHIGHISGPNSPLIGHKLSEMDSVL---MKIHTSLLSKDRETLLPSLLVLCGDHGMSETGSHGAS 280

  Fly   267 SPLEVETPLFMWGAGVKRDEIDAEANFPEKPNISQVDQTQLAPLMSSLIGLPPPKNNLA--LMPV 329
            |..||.|||.:..:..:|...|..       :...|.||.||..::..:|||.||:|:.  |.||
  Rat   281 STEEVSTPLLLISSAFERKPGDVR-------HPKHVQQTDLAATLAIGLGLPIPKDNVGSLLFPV 338

  Fly   330 GYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYKWLPKFKELHIGVIDQYAAQFDILKSE 394
            .......| |...||||.|||....:..|..:||...::.....:.||        ..:..|..|
  Rat   339 IEGKQMRE-QLRFLHLNTLQLSKLLQENIPAYEKDPGFEQFKMAERLH--------GNWVKLHLE 394

  Fly   395 GNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSYMIWFYCLLLQLTRLSKKEKMQRRGF 459
            .|.:|.:     .| |..|.|   .||......::.|:|..:..|.:.                .
  Rat   395 ENHSDIL-----LG-LGTKVL---RQYLGALKTLSQSLSTQVAHYDIY----------------S 434

  Fly   460 MTVSTLILAMIGILLIAMMELQKVPHIAAFYLILPVGMLIMAQAERPVRGYWIFHPLWNFGFILV 524
            |.|.||:     :|.:..:.|...||:......|.|.:|      .||     |..|:...|:::
  Rat   435 MAVGTLM-----VLEVLTLFLLSTPHVLCRKAELDVPLL------SPV-----FSLLFYLIFLVL 483

  Fly   525 PAVLIM------SMTFIIRHLWVLYGISVLLNNRRALRKPSIKLFIWLSLALIVTAILFMEQRTI 583
            .|:.::      |..::....|:..|                      ::.::|:|
  Rat   484 SAIHVLVCTSSESSCYLCNLPWLAAG----------------------AVMVLVSA--------- 517

  Fly   584 KGLKTIPVKDYHVLYVSMVLAIIRPLILGH--RHDPRV----WTFNSLTLVVGAFGVYQYKFYES 642
                         |:.:::.|:||.:..|.  |.:..|    |:..:|.|::|..|   :.....
  Rat   518 -------------LFCAILSALIRMVTDGTLLRKNATVASSGWSEVNLLLLLGTVG---HVLSLG 566

  Fly   643 VSSYVYV--VTWSFLFFAFLSIV-------YFA--KSLPEARKRLELITINMITVLSLLTNSWGC 696
            .||:|..  .||.||.......:       ||.  ...|:...::|...:|::.  ..|.:|..|
  Rat   567 ASSFVEEEHQTWYFLINTLCLALSQETCRSYFLGDDCEPQHHFQVEQKCVNVLA--CTLQDSTSC 629

  Fly   697 LNFQIAITEFIFGLQIYEETKETKEIEDAK-----DEHTSLQ----------------------- 733
                              .|.|::.....|     :.|.|.:
  Rat   630 ------------------STPESESDTAGKRASLLEAHRSCKWWTVLASPWLVLICCRLLRSLNQ 676

  Fly   734 -NLKGFYRYGYMILLYFYVSFFLAGHWISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIF 797
             .::|.:|..:             .||::|...|        .|.|...|.|||        |||
  Rat   677 TGVQGAHRPDF-------------SHWLTSSDHK--------VHLSGLAALSLV--------VIF 712

  Fly   798 I-----CALYAMVPFVRKNARSI-LISIFMISNAMGLYQYYFIRNRGSWRKIRMFLDQILLTHAV 856
            |     |:|      |.|.|.:: |:.:|....|:|:..:       .|:.....:.:.:.....
  Rat   713 ILVQKGCSL------VSKVALALGLLGVFCYRAAIGIVLF-------PWQPDNKGISKGITEARF 764

  Fly   857 NFMLLLGI 864
            .::.:|||
  Rat   765 VYVFVLGI 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	80/351 (23%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	85/482 (18%)
Pigg	XP_003751363.1	GPI_EPT_2	62..335	CDD:293748	76/330 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810