DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13978 and pign

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_002934435.2	Gene:	pign / 100497214	XenbaseID:	XB-GENE-960725	Length:	929	Species:	Xenopus tropicalis

Alignment Length:	996	Identity:	254/996 - (25%)
Similarity:	437/996 - (43%)	Gaps:	184/996 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQALVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRAATFL---ANN 65
            |..|.||::...:|.:.||...|:..:.|..|    .|.|||.|||:||.|||||.||.   .|.
Frog     6 LAGLAVHLVFFTSIFDIYFTSPLVHGMTPHHT----SLPPPAKRLVLFVADGLRADTFFELDENE 66

  Fly    66 GSDVPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFHEDPAASLMHLCYNPGDFDTVFNRSR 130
            .|..|.|::|...:|..|:|.|..||.:||||:|:.|||:||.:|.......||.:||::||.|:
Frog    67 TSRAPYLRNIIETRGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSIFNESK 131

  Fly   131 NMIGWAHSYIVGYFVKLSHGGAPLR--FDSYMERDLPEKLT-CDKWAFDKVENFLRNVDN----V 188
            ....|....|:..|.|.:.|.....  :.:..|....:..| .|.|.|:.::.|..:..:    :
Frog   132 FTWSWGSPDILPMFAKGASGDHIFTHCYSANSEDFASDDATKLDTWVFEHLKAFFSSAHSNQTLL 196

  Fly   189 REWRNYKPAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVF-NDSRTAYLMT 252
            |: .|.:..|||::|..:|...|..||.|:::...::...:||:....|.|..: ||:.|||::|
Frog   197 RK-LNEEKIVFFLHLLGLDTNGHAHKPGSREYKENVKKVDKGIKEVALLLEDFYGNDNNTAYILT 260

  Fly   253 SDHGMNNEGAHGSGSPLEVETPLFMWGAGVK-----RDEIDAEANFPEKPNI--SQVDQTQLAPL 310
            |||||.:.|:||:|.|.|..|||..|||||:     :::.|.::...:..::  :.|:|..:|||
Frog   261 SDHGMTDWGSHGAGHPSETLTPLVAWGAGVRYPTKVQEQSDKQSKAWKLEHLKRNDVNQADVAPL 325

  Fly   311 MSSLIGLPPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYKWLPKFKE 375
            |:||||:|.|.|::.::|..|||.|:.::|.::..|.||:|.|.::.:.:.::.........|..
Frog   326 MASLIGIPYPLNSVGILPGEYLNNSELFKAESMLTNALQILEQFKVKMAQKKETTLPFLFSPFSL 390

  Fly   376 LHIGVIDQYAAQFDILKS------EGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSY 434
            |      ..:.|.|||:.      ..|..:||..|:....||.:.|.||:.|.:..|.::....:
Frog   391 L------SDSKQLDILRKTRSYIHRENYKEAMALCENLIDLALRGLAYYHTYDRFFLGISVFAGF 449

  Fly   435 MIWF-YCLLLQL---TRLSKKEKMQRRGFMTVSTLILAMIGILLIAMMELQKVPHIAAFYLILPV 495
            ..|. |.:|:.|   |.::|......:...:|:...::.:||.:|..::.|..|.....|.:||:
Frog   450 SGWISYVILVILRTNTGITKDSLKLNKEKTSVAQYAVSALGIFIIIFLKSQSCPWTYYIYCLLPI 514

  Fly   496 GMLIMAQAERPVRGYWI-----------FHPLWNFGFILVP--AVLIMSMTFIIRHL-------- 539
            .:......|      |.           ..||...||:.|.  .:.::.::|..|.:
Frog   515 PVWYAVSKE------WYILCNLTDCLQSLSPLRIVGFLTVTFMGIEVLVLSFFYRSILTVGLIAF 573

  Fly   540 --W-VLYGISVLLNNRRALRKPSIKLFIWLSLALIVTAILFM-----EQR----TIKGLKTIPVK 592
              | |:..||.         :..|...||:.|.|::.....|     |..    |..||..:.:.
Frog   574 ACWPVVMQIST---------QAKITTLIWVFLCLLLAVFPLMPVVGKEPNITLVTTAGLLALLIS 629

  Fly   593 DYHVLYV-------------------SMVLAIIRPLILGHRHD--------PRV-----WTFNSL 625
            ....|:|                   .|::.|:...|:...|.        |.:     ||..:.
Frog   630 LVSCLWVIYKRKNKSAGNIDKMVHVCQMLILILAMYIVNTTHSSLAAKQGLPLINQIVSWTVLAS 694

  Fly   626 TLVVGAFGVYQYKFYESVSSYVYVVTWSFLFFAFLSIVYFAKSLPEARKRLELITINMI------ 684
            .|||.                  :.|.:.||...|||.            |.|::..::
Frog   695 ALVVP------------------LCTTAVLFQRLLSIF------------LSLMSTYLLLSTGYE 729

  Fly   685 ----TVLSLLTNSW-----GCL-NFQIAITEFIFGLQIYEETKETKEIEDAKDEHTSLQNLKGFY 739
                .|||.|..:|     |.| .:.::....:.|:....|..:::::           ||...
Frog   730 ALFPLVLSCLMCTWIYIEQGTLVKYGLSFKYMLNGIDFSPEITQSRQL-----------NLDDI- 782

  Fly   740 RYGYMILLYFYVSFFLAGHWISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIFICALYAM 804
            |..:.::.:...:||..|:..|...|.|.:...|...||.::.|.|::.||.||.|:.:||...:
Frog   783 RRSFFLVFFIITAFFGTGNIASINSFDPASVYCFLTVFSPFVMGGLMMWKILIPFVLVMCAFETV 847

  Fly   805 VPFVRKNARSILISIFMISNAMGLYQYYFIRNRGSWRKIRMFLDQ--ILLTHAVNFMLLLGISLA 867
            ....:.:::.:.:.:.:|::.|.|:.::.:::.|||..|...:..  |:::..:..|||.|:
Frog   848 QISAQISSKCLFLIVLVITDIMSLHFFFLVKDYGSWLDIGTSISHFVIVMSTTIFLMLLSGL--- 909

  Fly   868 KIFLANTTMERP-GQKRARTT 887
             :....||...| .||:..:|
Frog   910 -VHYLTTTKIIPWRQKKHHST 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	109/303 (36%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	96/509 (19%)
pign	XP_002934435.2	GPI_EPT_1	40..343	CDD:293744	109/303 (36%)
pign	XP_002934435.2	PigN	429..882	CDD:398585	96/509 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I6587
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010