DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13978 and enpp2

DIOPT Version :9

Sequence 1:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_009290357.1	Gene:	enpp2 / 100332039	ZFINID:	ZDB-GENE-040426-1156	Length:	854	Species:	Danio rerio

Alignment Length:	874	Identity:	151/874 - (17%)
Similarity:	277/874 - (31%)	Gaps:	346/874 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LEPPADRLVVFVTDGLRAATFLANNGSDVPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFH 105
            :.||   :::...||.| |:::...|:.:|:::.:..........|...||.|.|....|..|.:
Zfish   157 VRPP---VIMLSVDGFR-ASYMKRGGTVIPNIEKLRSCGTHAPYMRPMYPTKTYPNLYTITTGLY 217

  Fly   106 EDPAASLMHLCYNPGDFDTVFN-RSRNMIGWAHSYIVGYFVKLSH---GGAPLRFDSYMERDLPE 166
            .:....:.:..::| .||..|| |.:.              ||:|   ||.|: :.:.|::.:
Zfish   218 PESHGIVGNSIHDP-SFDANFNFRGKE--------------KLNHRWWGGQPI-WITAMKQGV-- 264

  Fly   167 KLTCDKWAFDKVENFL--------RNVDNVREWRNY----KPAVFFVYLADMDIAAHRFKPLSKK 219
                      |..:|.        |.|..:.:|.:.    :|.::.::...:|...|:..|.|.:
Zfish   265 ----------KAGSFFWPVAIPMERRVLTMLQWLHLPDAERPYLYAMHSEQLDSYGHKLGPHSTE 319

  Fly   220 FFAKLQYTQRGIRNTYELFERVFNDSRTAYL-------MTSDHGMNNEGAH-------------- 263
            .       ...:|:..::..::.|..:...|       :..||||  |.||
Zfish   320 L-------NSALRDVDKVIGQLMNGLKQMKLHRCINIILVGDHGM--EEAHCDKTEFLSSYMSNT 375

  Fly   264 -------GSGSPLEVETPLFMWGAGVKRDEIDAE---ANFP-EKPNISQVDQTQLAPLMSSLIGL 317
                   ||...:....|        ...:.||:   ||.. :||     || ...|.:...:
Zfish   376 EDLILIPGSLGRIRARNP--------NNSKFDAKAVVANLTCKKP-----DQ-HFKPYLKQHL-- 424

  Fly   318 PPPKNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILI---GRHEKAIF------------- 366
              ||.         |:.::..:...:||.|.:....|..::   ..|||..|
Zfish   425 --PKR---------LHYANNDRIEEIHLMVERKWHIARKIMKTKRNHEKCGFAGDHGYDNKINSM 478

  Fly   367 ----------YKW---LPKFKELHIGVIDQYAAQFDIL---KSEGNLTDAMEFCKEYGKLAKKCL 415
                      :|:   :|.|:.     |:.|....|:|   .:..|.|        :|.|
Zfish   479 QTIFLGYGPAFKFKTKIPPFEN-----IELYNIMCDLLGLKPAPNNGT--------HGSL----- 525

  Fly   416 TYYNQYYQTPLIVANSMSYMIWFYCLLLQLT---------------------RLSKKEKMQRRGF 459
               ||..:||:.:.|...          ::|                     ::|.|.|:.
Zfish   526 ---NQLLRTPVYIPNMPE----------EVTKPNPAGPVIAINDDLGCTCEDKVSNKNKVD---- 573

  Fly   460 MTVSTLILAMIGILLIAMMEL-QKVPHIAAFYLILPVGMLIMAQAERPVRGYWIFHPLWNFGFIL 523
                               || |::..:......||.|.
Zfish   574 -------------------ELNQRLRQVIDDNKNLPYGR-------------------------- 593

  Fly   524 VPAVLIMSMTFIIRHLWVLYGISVLLNNRRALRKPSIKLFIWLSLAL------------------ 570
             |||:..:...|:.|...:.|.|      .||..|     :|.|..:
Zfish   594 -PAVMFRTKYCILHHTDYISGYS------EALHMP-----LWTSYTVSKQVDFTPLTDALSNCIR 646

  Fly   571 ----IVTAILFMEQRTIKGLKTIPVKDYHVLYV------------SMVLAIIRPLILGHRHDPRV 619
                :.||.    .::....:|.....|..||.            ::::....|:....:   ||
Zfish   647 PDSRVPTAY----SQSCSNYRTEKQISYSFLYPPQLSSTQEARYDAVLITNTVPMYAAFK---RV 704

  Fly   620 WTFNSLTLVVGAFGVYQYKFYESVSSYVYVVTWSFLFFAFLSIVYFAKSLPE-ARKRLELITINM 683
            |::...:||         |.|.|..:.|.|||.....:.:..:...|:::.: ....:::.|...
Zfish   705 WSYFQKSLV---------KRYASEKNGVNVVTGPIFDYDYNGLRDSAETIKQFVSGSVQIPTHYF 760

  Fly   684 ITVLSLLTNSWGCLNFQIAITEFIFGLQIY----------EET-----KETKEIEDAKDEHTS-- 731
            :.|.|       ||::...:...:..|.::          |||     .|:|.:|:....||:
Zfish   761 VVVTS-------CLDYTQTVDSCVGPLSVFSFILPHRSDNEETCNSSEDESKWVEELMKTHTARL 818

  Fly   732 --LQNLKG--FYR-----YGYMILLYFYV 751
              ::.|.|  |||     |..::.|..|:
Zfish   819 RDVELLTGLDFYRRTSRTYEEILALKTYL 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	62/333 (19%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	69/421 (16%)
enpp2	XP_009290357.1	Somatomedin_B	52..91	CDD:279385
		SO	98..137	CDD:197571
		Enpp	159..512	CDD:293742	77/425 (18%)
		Phosphodiest	161..472	CDD:279931	69/375 (18%)
		NUC	589..846	CDD:238043	56/317 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900