DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side and NPHS1

DIOPT Version :9

Sequence 1:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens

Alignment Length:	871	Identity:	197/871 - (22%)
Similarity:	302/871 - (34%)	Gaps:	229/871 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 RCPDNGKTIWAVGFTLVLLTCLQQLKSVSADEESQDFQKNI------PARLVW---------AAL 104
            |..|||.|          |||    ::.|.....:.|:|::      ||:.:|         ...
Human   407 RREDNGLT----------LTC----EAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRA 457

  Fly   105 GKTVELPCDLTPPTSQDSVKLLLWFKDTTGIPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIGD 169
            |..|.|.|.......:.|   |:|:||:..:....|......|.|.......|...:.|....|
Human   458 GTRVRLVCLAIGGNPEPS---LMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTG- 518

  Fly   170 NPKDSRLQINDVKPEDGGVYRCRVDFFNSPTRNFRHNLTLVVPPEEPRIFDAQGKEISQMAGPFR 234
             |.|::.:           :.|:....::.|:     |.:..||....|.        ..|...|
Human   519 -PSDNQAK-----------FTCKAGQLSASTQ-----LAVQFPPTNVTIL--------ANASALR 558

  Fly   235 EGYELFLCCQVRGGRPPPKVTWWRDDTELIGTS---HTSVEEGATVMVNQLLIGTTTRDFYGIRI 296
            .|..|.|.|......||..::|.::...|.|.:   ..:..:|:.. ...:|:..::|| :|.|:
Human   559 PGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAA-ARSVLLQVSSRD-HGQRV 621

  Fly   297 ECRAQGTRLVDPVRKDVTVQVYLKP----VRVKIATPNELLTAGQPMPIRCESWGSYPAAK-ITW 356
            .|||....|.:.|.....:.|..:|    .:|.:.|..|...|..|:.:     .:.||.: ..|
Human   622 TCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSV-----SANPAPEAFNW 681

  Fly   357 LLDGEPIRNAEVTVHSDKEDGNITTSILTLKVTSENDNA-ELTCRATNPWFSGGAIEDKRIIRVA 420
            ...|..:..|....|.....|    ::....||..:|.. :|.|:.     |.|..|.:..:.|.
Human   682 TFRGYRLSPAGGPRHRILSSG----ALHLWNVTRADDGLYQLHCQN-----SEGTAEARLRLDVH 737

  Fly   421 YPPTVSVHLANEDPSRLVTRAEGQNVTFKCRADARPPVTS-YSWFKNGMRMSGESTEIMHLTQLE 484
            |.||:.   |.:||:.:..   |.:|...|..||.|.:.. ::|     ...||..|...|..:|
Human   738 YAPTIR---ALQDPTEVNV---GGSVDIVCTVDANPILPGMFNW-----ERLGEDEEDQSLDDME 791

  Fly   485 RES----------------AGAYACGATNTEGETRSSSLTLKVQFSPRCKSGTEQTSIGAV--SL 531
            :.|                ||||.|...|.........|.|.|:|:|:.:..|..|.:.|.  |.
Human   792 KISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDST 856

  Fly   532 HSILVKCEVDADPPDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTVTYLPQTDSELITLA----- 591
            .|..:.|.....|  ::.|:||.|..    |:   .:|.........:.....|.|:|:|
Human   857 SSATLHCRARGVP--NIVFTWTKNGV----PL---DLQDPRYTEHTYHQGGVHSSLLTIANVSAA 912

  Fly   592 -------CWASNAVGR-QTTPCLVHILPANTPEAPKACELRNDTV-LEVVCVAGSDGGLSQYFML 647
                   |.|:||:|. ||...||.|...:.|...|...|...:| ||  ...|.||||.|.|.:
Human   913 QDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLE--WKPGFDGGLPQRFCI 975

  Fly   648 EVVGGDPLYSGDPGGSAGQGRGQFSEAIGL-GDNEISTLNDQATSAPIFRMQENSPQFRLNNLEP 711
            ..                       ||:|. |.:.:..:..|||:            |.|..|:|
Human   976 RY-----------------------EALGTPGFHYVDVVPPQATT------------FTLTGLQP 1005

  Fly   712 GREYQFLVYAVNAKGRS-------EPPVVIENVRVAAQLGPYDESILSEDPTPAETTHHGGGGVG 769
            ...|:..:.|.||.|.|       :.|:...        |.:..|...||..|.|..
Human  1006 STRYRVWLLASNALGDSGLADKGTQLPITTP--------GLHQPSGEPEDQLPTEPP-------- 1054

  Fly   770 GSGSSSGLGTGASTGSGPEKQSTLLILAAVVVIGAVVVTS--IIVAGIVVVCRHRPRPPEPQEVR 832
                           |||   |.|.:|..:..:|.:::.|  ..|.|::...|.|.......|
Human  1055 ---------------SGP---SGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGISE-- 1099

  Fly   833 KSMRPARNDVPSMYIEEDEL-NELEE 857
                  :.:..|   |||.: ||.||
Human  1100 ------KTEAGS---EEDRVRNEYEE 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side	NP_001247334.1	V-set	95..211	CDD:284989	23/130 (18%)
		IG_like	100..211	CDD:214653	21/119 (18%)
		Ig	235..301	CDD:299845	17/68 (25%)
		Ig	326..408	CDD:299845	16/83 (19%)
		IG_like	329..407	CDD:214653	15/79 (19%)
		IG_like	435..511	CDD:214653	21/92 (23%)
		Ig_2	442..511	CDD:290606	21/85 (25%)
		FN3	<700..735	CDD:238020	11/41 (27%)
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423
		Ig	240..321	CDD:299845
		IG_like	254..336	CDD:214653
		Ig	345..424	CDD:299845	9/30 (30%)
		Ig	445..530	CDD:299845	19/100 (19%)
		I-set	446..541	CDD:254352	20/115 (17%)
		Ig	549..632	CDD:299845	22/92 (24%)
		IG_like	558..642	CDD:214653	21/85 (25%)
		I-set	646..736	CDD:254352	21/103 (20%)
		Ig	662..736	CDD:299845	17/87 (20%)
		Ig_3	739..820	CDD:290638	23/91 (25%)
		IG_like	748..821	CDD:214653	19/80 (24%)
		Ig8_hNephrin_like	834..942	CDD:143250	30/116 (26%)
		IG_like	845..935	CDD:214653	23/98 (23%)
		fn3	942..1023	CDD:278470	29/117 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		8/62 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		9/29 (31%)
		Binds to NPHS2	1160..1241
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810