DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side and sns

DIOPT Version :9

Sequence 1:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster

Alignment Length:	1098	Identity:	217/1098 - (19%)
Similarity:	366/1098 - (33%)	Gaps:	291/1098 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NIPARLVWAALGKTVELP--------------------------CDLTPPTSQD----SVKLLLW 128
            |.||:|:|...|..:.:.                          |:.:...||:    .|:|.:.
  Fly   313 NPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVL 377

  Fly   129 FKDTTGIPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRCRV 193
            |..|....:...::|.|::.........|:....:.:.:|.....:......|.||.|......:
  Fly   378 FAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNI 442

  Fly   194 DFFNSP----------------TRNF--RHNLTLVVPPEEPRIFD-AQGKEISQMAGPFREGYEL 239
            .....|                |.|.  .|.:.::.||..|.|.. .:|:.|.  ||..::
  Fly   443 TAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIP--AGSVQK---- 501

  Fly   240 FLCCQVRGGRPPPKVTWWRDD---TELIGTSHTSVEEGATVMVNQLLIGTTTRDFYGIRIECRAQ 301
             |.|...||.|...:||:::|   ..:|..:..||....|::.|   :......:     .|.|.
  Fly   502 -LLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILAN---VSDNQAQY-----RCEAS 557

  Fly   302 GTRLVDPVRKDVTVQVYLKPVRVKIATPNELLTAGQPMPIRCESWGSYPAAKITWLLDGEPIRNA 366
            .:....|:.:..|:.|:..|..|||....|.|..|....|.|:|..|.|.||::|..||.||...
  Fly   558 NSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGI 622

  Fly   367 EVTVHSDKEDGNITTSILTLKVTSENDNAELTCRATNPWFSGGAIEDKRIIRVAY-----PPTVS 426
            ..|.......|.::|....:.||.|.:....||::.|......|.|... :.|.|     ||
  Fly   623 NNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVS-LDVLYRPKFVPP--- 683

  Fly   427 VHLANEDPSRLVTRAEGQNVTFKCRADARPPVTSYSWFKNGMRMSGESTE-------IMHLTQLE 484
                   ||......||:::....:..|.|...:|.|.|:|..:..:...       .::.|:|.
  Fly   684 -------PSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLH 741

  Fly   485 RESAGAYACGATNTEGETRSSSLTLKVQFSPRCKSGTEQTSIGAVSLHSILVKCEVDADPPDSVR 549
            |:.||.|:|.|:|::|.. :.::|:.|::....||.:|...:...  ...::.|.|:..|.....
  Fly   742 RDDAGIYSCSASNSQGGA-TLNITVVVEYGTTIKSVSENIVVNPG--EDAMLSCTVEGKPLTEEH 803

  Fly   550 FSWT---YNNTRNVSPVLNSRIQSNGLASTVTYLPQTDS---ELITLACWASNAVGRQT------ 602
            ..|.   |:.|     |..|...:||    .:||...|:   ::....|.|.|.|...|
  Fly   804 VKWERVGYDMT-----VKTSTTFANG----TSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILL 859

  Fly   603 ----------TPCLVHI---------LPANTPEAPKACEL-RNDTVLEVVCVAGSDGGLSQYFML 647
                      ||.|:..         ||.....:||...: |.|.         .|..:::.:..
  Fly   860 IVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDK---------KDLPINRTYKY 915

  Fly   648 EV-------------VGGDPLYSGDPGGSAGQGRGQFSEAIGLGDNEISTLNDQATSAPI----- 694
            ||             :..|.:...|.|......|.:..||:.....||::..|...|..|
  Fly   916 EVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTH 980

  Fly   695 ----------------------FRMQE-----------NSPQFRLNNLEPGREYQFLVYAVNAKG 726
                                  :||.:           ||.:..:..|.....|.|.|.:.|..|
  Fly   981 DTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELG 1045

  Fly   727 RSEPPVVIENVRVAAQLGPYDESILSEDPTPAETTHHGGGG--------VGGSGSSSGLGTGAS- 782
            :|            :.|.....:...|.|.|:......|||        :||:.....:|.||.
  Fly  1046 QS------------SYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGI 1098

  Fly   783 ---------------------------------TGSGPEKQSTLLILAAVVVIGAVVVTSIIVAG 814
                                             |.......:.::|..::...|.::|.:.:||.
  Fly  1099 VVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAW 1163

  Fly   815 IVVVCRHRPRPPEPQEVRKSMRPARNDV--PSMY-----------IEEDELNELEEGGGRAA--- 863
            ..|   |:.|....:...:..:.|..::  ||.|           :.|...:...||..:..
  Fly  1164 FFV---HQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYID 1225

  Fly   864 DIRARVAPPNSHLCGGGGMPMPGGVGSSGGAIVGVAGPHHYISESFIQYAQPSLNGDVLLPLLVT 928
            ::|.:.|  :::|..|..||.|   .......:.|..|::.::...:.:.:.: ||...:.:...
  Fly  1226 EVRKKAA--STYLVEGSDMPPP---RYQKDGTLPVIYPNNVVNACTLPHPRHN-NGSAAIHMTRD 1284

  Fly   929 SSQPCSTNSTISSVVLAMPQAKLCPD------PASRNTAWPP-EYPDLILPRGELEFT 979
            .....|....|.|...|.|     ||      .:.|..::|| |||      ..|:||
  Fly  1285 DQMLISKGVYIPSPSPAPP-----PDGSYYNMNSDRYLSYPPMEYP------AALDFT 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side	NP_001247334.1	V-set	95..211	CDD:284989	24/163 (15%)
		IG_like	100..211	CDD:214653	21/158 (13%)
		Ig	235..301	CDD:299845	14/68 (21%)
		Ig	326..408	CDD:299845	25/81 (31%)
		IG_like	329..407	CDD:214653	24/77 (31%)
		IG_like	435..511	CDD:214653	20/82 (24%)
		Ig_2	442..511	CDD:290606	19/75 (25%)
		FN3	<700..735	CDD:238020	9/34 (26%)
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	11/62 (18%)
		Ig	300..361	CDD:299845	7/47 (15%)
		Ig	380..454	CDD:299845	10/73 (14%)
		IG_like	490..573	CDD:214653	21/97 (22%)
		Ig	501..560	CDD:299845	15/71 (21%)
		Ig	584..666	CDD:299845	24/81 (30%)
		IG_like	585..666	CDD:214653	24/80 (30%)
		I-set	678..767	CDD:254352	23/99 (23%)
		IGc2	692..757	CDD:197706	17/64 (27%)
		Ig	788..849	CDD:143165	16/69 (23%)
		Ig	885..960	CDD:143165	15/83 (18%)
		FN3	967..1051	CDD:238020	14/95 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810