DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side and side-II

DIOPT Version :9

Sequence 1:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	269/946 - (28%)
Similarity:	407/946 - (43%)	Gaps:	191/946 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SVSADEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQDSVKLLLWFKDTTGIPLYSLDSRGG 145
            |.|....|:|  .::..:.:.|..||:|.|||.:|.|.  |:|.::|||:|..||||||.|.|..
  Fly    40 SGSGGISSKD--SHVKTKDIDAVEGKSVSLPCPITEPL--DNVYMVLWFRDNAGIPLYSFDVRDK 100

  Fly   146 NVKLAP-HAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRCRVDFFNSPTRNFRHNLTL 209
            ..:..| |.:.....|.|..|..     ||:....::|..|.|:|||||||..|.|::||.||::
  Fly   101 ESREQPRHWSAPEVFGSRAKFHF-----DSQPATLEIKRHDQGIYRCRVDFRTSQTQSFRFNLSV 160

  Fly   210 VVPPEEPRIFDAQGKEIS-QMAGPFREGYELFLCCQVRGGRPPPKVTWWRDDTELIG---TSHTS 270
            ::.||:|.|.|..|:::: ...||.:||.::.:.|:|.||||.|:|.|      |:.   ..:.:
  Fly   161 IILPEQPIIMDRWGRQLNGTQLGPKQEGDDIVITCRVVGGRPQPQVRW------LVNGLLVDNQN 219

  Fly   271 VEEGATVMVNQLLIGTTTRDFYGIRIECRAQGTRLVDPVRKDVTVQVYLKPVRVKIATPNELLTA 335
            ......|:.|:||..:..|:.......|:|..|:|..|..|...:.::|||:.|||..|...:.|
  Fly   220 EHNSGDVIENRLLWPSVQRNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIA 284

  Fly   336 GQPMPIRCESWGSYPAAKITWLLDGEPIRNAEVTVHSDKEDGNITTSILTLKVTSENDNAELTCR 400
            .:...:.|||.||.|.|.|||......:|..:     |....|.|.|.|:...|:::|...:|||
  Fly   285 DRRYEVSCESSGSRPNAIITWYKGKRQLRRTK-----DDISKNSTRSELSFVPTTDDDGKSITCR 344

  Fly   401 ATNPWFSGGAIEDKRIIRVAYPPTVSVHLANE-DPSRLVTRAEGQNVTFKCRADARPPVTSYSWF 464
            |.||..:|..:|....:.|.|||.|::.|.:. .|..:   .||.:|.|:|...:.|......|.
  Fly   345 AENPNVNGLYLETMWKLNVVYPPLVTLRLGSTLTPDDI---KEGDDVYFECHVQSNPQWRKLLWL 406

  Fly   465 KNGMRMSG-------ESTEIMHLTQLERESAGAYACGATNTEGETRSSSLTLKVQFSPRCKSGTE 522
            .||:.:..       .|.:.:.|.::.:..||.|||.|.|.||||.|:.|.|:|:::|.||....
  Fly   407 HNGIHLEHNTSARVIRSNQSLVLQKITKHYAGNYACSAINDEGETVSNQLPLRVKYTPMCKHADR 471

  Fly   523 QTSIGAVSLHSILVKCEVDADPPDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTVTYLPQTDSEL 587
            ...|||....::.|.||:.||||... |.|.:||:.....|.:.|...||..|.:.|.|.||.:.
  Fly   472 VILIGASKDETVEVVCEIQADPPPRT-FRWKFNNSGETLDVGSERFSVNGSRSILKYTPVTDQDY 535

  Fly   588 ITLACWASNAVGRQTTPCLVHILPANTPEAPKACELRNDTVL--EVVCVAGSDGGLSQYFMLEVV 650
            .||:|||||.||.|..|||..::.|..|.|...|.:.|.|.|  ::.|:.|.||||.|.|:||:.
  Fly   536 GTLSCWASNEVGTQQHPCLFQVVLAALPNAVSNCTVFNRTELSVDIQCIPGYDGGLPQIFVLEMF 600

  Fly   651 GGDPLYSGDPGGSAGQGRGQFSEAIGLGDNEISTLNDQATSAPIFRMQENSPQFRLNNLEPGREY 715
                        |...|..:|:  :...:..:.:|.:..|...:...:.||.:.|
  Fly   601 ------------STRTGITRFN--LSNAEEALFSLENLDTLTSMMVQENNSLRLR---------- 641

  Fly   716 QFLVYAVNAKGRS-------------------------EPPVV---------------------- 733
               :|:.|.||||                         .|.:|
  Fly   642 ---IYSYNQKGRSAAYLLTDFIIGSTAYKTDDDVTLTLSPVIVGSVLTIIIIGVAIAIRIFVVTF 703

  Fly   734 IENVR-------------VAAQLGPYD----------------------ESILSE--DPTPAETT 761
            :.|:|             |.||  |.|                      |.::.:  ||....:.
  Fly   704 VHNLRRNRHHGSKATAAGVTAQ--PSDVFKGGNLEKPRWQHTDIKTKSSEDLVEDERDPDVIPSQ 766

  Fly   762 HHGGGGVGGSGS-SSGLGT---GASTGSGPEKQSTLLI----LAAVVVIGAVVVTSI-------- 810
            :.||...|.||| :|.:|:   |.:|||   ..||.::    .||..:.|....||.
  Fly   767 YVGGSSAGSSGSNASNVGSTTAGTATGS---STSTAVVANANAAASAMAGPGGATSSASATDGHQ 828

  Fly   811 IVAGIVVVCRHRPRPPEPQEVRKSMRPARNDVPSMYIEEDELNELEE---------GGGRAADIR 866
            ..:|.........:......|..:|  ...|..:..:..:::|....         |||    ..
  Fly   829 FASGTAAAGGGASKWSPNGNVTTTM--LTGDAVNATVTYNQINAQRAQLLAAVAAVGGG----CS 887

  Fly   867 ARVAPPNSHLCGGGGMPMPGGVGSS-----GGAIVG 897
            :.|..|:|.:.||.|.|:..|:|..     ||.::|
  Fly   888 STVISPSSSILGGLGKPLGMGMGMGLGMGVGGTVIG 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side	NP_001247334.1	V-set	95..211	CDD:284989	46/116 (40%)
		IG_like	100..211	CDD:214653	46/111 (41%)
		Ig	235..301	CDD:299845	18/68 (26%)
		Ig	326..408	CDD:299845	27/81 (33%)
		IG_like	329..407	CDD:214653	26/77 (34%)
		IG_like	435..511	CDD:214653	25/82 (30%)
		Ig_2	442..511	CDD:290606	25/75 (33%)
		FN3	<700..735	CDD:238020	11/81 (14%)
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	46/111 (41%)
		Ig	57..160	CDD:299845	46/109 (42%)
		Ig	188..251	CDD:299845	18/68 (26%)
		Ig	289..363	CDD:299845	26/78 (33%)
		IG_like	289..351	CDD:214653	24/66 (36%)
		Ig_2	376..460	CDD:290606	26/86 (30%)
		IG_like	383..454	CDD:214653	22/70 (31%)
		Ig	470..548	CDD:299845	31/78 (40%)
		IG_like	481..557	CDD:214653	33/76 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470111
Domainoid	1	1.000	41	1.000	Domainoid score	I12487
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139790at33208
OrthoFinder	1	1.000	-	-		FOG0002810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	8	7.850