DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side and VSIG10L

DIOPT Version :9

Sequence 1:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	NP_001157394.1	Gene:	VSIG10L / 147645	HGNCID:	27111	Length:	867	Species:	Homo sapiens

Alignment Length:	936	Identity:	200/936 - (21%)
Similarity:	326/936 - (34%)	Gaps:	302/936 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TLVLLTCLQQL---KSVSADEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQ------DSVK 124
            ||...:.|||.   .:.|:|.:|             ::.|..||:| .:.||:.:      || |
Human    21 TLRASSGLQQTNFSSAFSSDSKS-------------SSQGLGVEVP-SIKPPSWKVPDQFLDS-K 70

  Fly   125 LLLWFKDTTGIPLYSLDSRGG----NVK-----LAPHAAIASDLGQRLFFSIGDNPKDSRLQIND 180
            ......|::..|.....:..|    ||.     |:|.:..:...|..:|..|    .|.::...|
Human    71 ASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFPDI----SDPQVPAKD 131

  Fly   181 VKPEDGGVYRCRVDFFNSPTRNFRHNLTLVVP-----PEEPRI-FDAQGKEI------------- 226
            .||.    :..:....|..|:.....|::..|     |::..: ..||..|.
Human   132 PKPS----FTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESKFSAETHSAASFP 192

  Fly   227 SQMAGPFR--EGYELFL-CCQVRGGRPPPKVTWWRDDTELIGTSHTSVEEGATVMVNQLLIGTTT 288
            .|:.||..  .|..:.| ...:....||..:..||..::::...  .:..||.:    :.:....
Human   193 QQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAG--GLGPGAPL----ISLDPAH 251

  Fly   289 RDFYGIRIECRAQGTRLVDPVRKDVTVQVYLKPVRVKIATPNELLTAG--QPMP----------- 340
            ||.  :|.: :|:|...:...:.|.......:.:|..::......|.|  :|:|
Human   252 RDH--LRFD-QARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPET 313

  Fly   341 --------IRCESWGSYPA-AKITWLLDGEPIRNAEVTVHSDKEDGNITTSI------LTLKVTS 390
                    :||..||  |. .:::|..||..:..||       .:|..|..:      |.:....
Human   314 EEGAAELRLRCLGWG--PGRGELSWSRDGRALEAAE-------SEGAETPRMRSEGDQLLIVRPV 369

  Fly   391 ENDNAELTCRATNPWFSGGAIEDKRIIRVAYPPTVSVHLANED--PSRLVTRAEGQNVTFKCRAD 453
            .:|:|..|||..:|:....|..|..:.....|||::|. ::.|  |:|.||  .|.|||.:|.|.
Human   370 RSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVS-SDRDAAPARFVT--AGSNVTLRCAAA 431

  Fly   454 ARPPVTSYSW---------FKNGMRMSGESTEIMHLTQLERESAGAYACGATNTE-GETRSSSLT 508
            :||| ...:|         ...|.|:.        |..:....||.|||.|.|.. |..|.|.|.
Human   432 SRPP-ADITWSLADPAEAAVPAGSRLL--------LPAVGPGHAGTYACLAANPRTGRRRRSLLN 487

  Fly   509 LKVQFSPRCKSGTEQTSIGAVSLHSILVKCEVDADPPD-SVRF--SWTYNNTRNVSPVLNSRIQ- 569
            |.|...|   .|..|              |.|:..|.| |:||  ||.     ..:|..:.:.|
Human   488 LTVADLP---PGAPQ--------------CSVEGGPGDRSLRFRCSWP-----GGAPAASLQFQG 530

  Fly   570 ----------SNGLASTVTYLPQTDSELITLACWASNAVGRQTTPCLVHILPANTPEAPKACELR 624
                      |:.|.:.|...|:...  :.:.|.|.:.|..:|  |.|      |||||:
Human   531 LPEGIRAGPVSSVLLAAVPAHPRLSG--VPITCLARHLVATRT--CTV------TPEAPR----- 580

  Fly   625 NDTVLEVVCVAGSDGGLSQYFMLEVVG------------GDPLYSGDPGGS----AGQGR----G 669
              .||....||.:..|.:: ..||..|            |.||..|  |||    :..||    |
Human   581 --EVLLHPLVAETRLGEAE-VALEASGCPPPSRASWAREGRPLAPG--GGSRLRLSQDGRKLHIG 640

  Fly   670 QF-------------SEAIGLGDNEISTLNDQATSAPIFRMQENSPQFRLNNLEPGREYQFLVYA 721
            .|             |.|:|.|.::|:.:....:|   :|:|.            .|:...|.:.
Human   641 NFSLDWDLGNYSVLCSGALGAGGDQITLIGPSISS---WRLQR------------ARDAAVLTWD 690

  Fly   722 VNAKGRSEPPVVIENVRVAAQ--------------------LGPYDES----------------- 749
            |      |...:|.:..:.|.                    |||.:.|
Human   691 V------ERGALISSFEIQAWPDGPALGRTSTYRDWVSLLILGPQERSAVVPLPPRNPGTWTFRI 749

  Fly   750 --ILSEDP-TPAETTHHGGGGVGGSGSSSGLGTGASTGSGPEKQSTLLILAAVVVIGAVVVTSII 811
              ||...| ||:::..:..|.....|:.:|:..|:                   ::|..::..::
Human   750 LPILGGQPGTPSQSRVYRAGPTLSHGAIAGIVLGS-------------------LLGLALLAVLL 795

  Fly   812 VAGIVVVCRHRPRPPEPQEVRKSMRP 837
            :..|..:||.|.:.||.::...::.|
Human   796 LLCICCLCRFRGKTPEKKKHPSTLVP 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side	NP_001247334.1	V-set	95..211	CDD:284989	26/130 (20%)
		IG_like	100..211	CDD:214653	26/125 (21%)
		Ig	235..301	CDD:299845	11/66 (17%)
		Ig	326..408	CDD:299845	23/109 (21%)
		IG_like	329..407	CDD:214653	23/105 (22%)
		IG_like	435..511	CDD:214653	28/85 (33%)
		Ig_2	442..511	CDD:290606	25/78 (32%)
		FN3	<700..735	CDD:238020	4/34 (12%)
VSIG10L	NP_001157394.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..60		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..186		17/89 (19%)
		Ig	198..298	CDD:299845	18/108 (17%)
		I-set	302..395	CDD:254352	22/101 (22%)
		Ig	320..389	CDD:143165	19/77 (25%)
		IG_like	418..490	CDD:214653	27/82 (33%)
		IGc2	421..476	CDD:197706	19/63 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..627		7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910