DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side and si:ch211-180a12.2

DIOPT Version :9

Sequence 1:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster
Sequence 2:	XP_001920945.3	Gene:	si:ch211-180a12.2 / 100150385	ZFINID:	ZDB-GENE-121214-236	Length:	903	Species:	Danio rerio

Alignment Length:	940	Identity:	185/940 - (19%)
Similarity:	303/940 - (32%)	Gaps:	289/940 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GKTVELPCDLTPPTSQDSVKL-LLWFKDTTGIPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIG 168
            |.:..|.|....|...|:..| :.|             |.||::       |||....:..|.:.
Zfish    28 GSSTVLNCSFALPALVDNSLLNITW-------------SSGGSI-------IASKNHTQAGFFLN 72

  Fly   169 DNPKDS-RLQINDVKPEDGGVYRCRVDFFNSPTRNFRHNLTLVVPPEEPRIF-DAQGKEISQMAG 231
            .....| .|.:.:..|...|||.|||. :|.........||::.||....|. :|..|..|.:.
Zfish    73 STAFPSFPLTVFNATPHQQGVYECRVS-YNDTDYATEVTLTILAPPVVSIISPEAVLKRKSVVE- 135

  Fly   232 PFREGYELFLCCQVRGGRPPP-KVTWWRDDTELIGTSHTSVEEGATVMVNQLLIGTTTRDFY--- 292
                       |..|...||. ..||.|...:        ::|...:.||:     |....|
Zfish   136 -----------CWARSFSPPQIMFTWTRGGNK--------IQEPQKLQVNR-----TEDGLYDAV 176

  Fly   293 ------------GIRIECRAQGTRLVDPVRKDVTVQVYLKPVRVKIATPNELLTAGQPMPIRCES 345
                        .|...|..|.:.||.||.::.|..:.:.|.......|:.  :....:.:.|:.
Zfish   177 SFLTFIPQISNQNISFGCEVQHSALVKPVLEEFTPHITVLPKVTLSVVPSS--SHSSSVTLSCDI 239

  Fly   346 WGSYP-AAKITWLLDGEPIRNAEVTVHSDKEDGNITT-SILTLKVTSENDNAELTCRATNPWFSG 408
            .|.|| ...:.|:.:|:.:  :|:.:....|||.... ...||.....:...|:.|.|..|  ||
Zfish   240 SGFYPNNISVLWIHNGKKL--SELPLSIQNEDGTYRRHQYHTLTREERSRGGEVQCVALQP--SG 300

  Fly   409 -----GAIEDKRI-IRVAYP------------PTVSVHLA----------NED------------ 433
                 |.|:...: :||..|            ..:|:.|.          ..|
Zfish   301 QEPANGTIDLSTVDLRVQNPGLNKSAKASVAMMIISLTLVFLLCFGFSWKRRDEKLKSLNISAIV 365

  Fly   434 -PSRLVTRAEGQ-NVTFKCRADARPPVTSYSWFKNGMRM------------------SGESTEIM 478
             |.|:|...:|: .::.:.|...|...|   ||.|.:.:                  :..::.:.
Zfish   366 LPPRVVVGKKGRVTISVEGRLAERVQTT---WFLNDIPIKDTSHKEKKYGAFRSASYTSRNSSVS 427

  Fly   479 HLTQ----LERESAGAYACGATNTEGETRSSSLTLKVQFSPRCKSGTEQTSIGAVSLH-SILVKC 538
            .|::    |...::|.|   ..:|:...||||.:.|..||       ..|.|.::::| ..:.||
Zfish   428 VLSEKNPLLPSSASGYY---KLHTQMPLRSSSNSSKQLFS-------SVTFIPSLAVHKGSVFKC 482

  Fly   539 EVDADPPDSVRFSWTYNNTRNVSPVLNSRIQSNGLASTVTYLPQTDSELITLACWASN------- 596
            :|.....|.:...........::|...|.||.:.        |..:..::|:...||:
Zfish   483 QVSYKGKDKIVAERVSEKFTILAPPEVSEIQFSE--------PNEEGGVVTMTAHASHFHPDIIT 539

  Fly   597 ----AVGRQTTPCLV-HILPANTPEA------------PKACELR----------NDTVLEVVCV 634
                ..|.:.:|..: ..|.|..|:|            ||| ||.          :.|.|:....
Zfish   540 FRWFCEGGELSPVSIPQALAAPRPDAEGFFSAMSQCRLPKA-ELERGETRVWVTIHHTALKQPIT 603

  Fly   635 AGSDGGLSQYFMLEVVGGDPLYSGDPGGSAGQGR--------GQFSEAIGL------------GD 679
            ..:.|.:.|..:.|::       ..|..|..:||        |.:...|.:            ||
Zfish   604 RQTRGFIKQPSISEIL-------SCPVASVLEGRLTLACEITGFYPPEISVKWLHSKGNEIEDGD 661

  Fly   680 NEISTLNDQATSAPIFRMQENSPQ-FRLNNLEPGREYQFLVYAVNAKGRSEPPVVIENVRVAAQL 743
            :....:.|   .|.::...:..|: ||.         :.|:..||...|...  :|..|.....|
Zfish   662 DSEEEIKD---GAEVWGPLQTLPRTFRA---------KALLKDVNEMTRGGQ--IICRVSHCCLL 712

  Fly   744 GPYD------ESILSEDPTPAETTHHGGGGV--------GGSGSSSGL-GTGASTGS-------- 785
            .|.|      .::....| |:.:.|....||        ||..|:..| ..|.||.|
Zfish   713 KPVDRVWRNTHTVAPSIP-PSLSVHWSSDGVGIFSIVLCGGRPSAEVLWAAGGSTLSRLQSKERE 776

  Fly   786 --GPEKQSTLLILAAVVVIGAVVVTSIIVAGIVVVCRHRPRPPEPQEVRKSMRPARNDVPSMYIE 848
              ..|.:..|..:.|:|                     |....:..|.|:.....:...||:...
Zfish   777 RENNEGKLELKSVCALV---------------------RSTGRKDSESRRGTHARKIRPPSVDFN 820

  Fly   849 ED--ELNELEEGGGRAADIRARVAP-PNSH 875
            .|  ::||..:|   ...::....| ||.|
Zfish   821 TDYEKVNECVDG---LKSVQEEKQPEPNKH 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side	NP_001247334.1	V-set	95..211	CDD:284989	26/107 (24%)
		IG_like	100..211	CDD:214653	26/107 (24%)
		Ig	235..301	CDD:299845	14/81 (17%)
		Ig	326..408	CDD:299845	17/83 (20%)
		IG_like	329..407	CDD:214653	17/79 (22%)
		IG_like	435..511	CDD:214653	18/98 (18%)
		Ig_2	442..511	CDD:290606	16/91 (18%)
		FN3	<700..735	CDD:238020	7/35 (20%)
si:ch211-180a12.2	XP_001920945.3	Ig	19..114	CDD:299845	26/106 (25%)
		IG_like	22..113	CDD:214653	25/105 (24%)
		C1-set	123..205	CDD:284964	20/106 (19%)
		IgC	237..309	CDD:143166	19/75 (25%)
		IgC	515..604	CDD:143166	17/97 (18%)
		IgC	609..720	CDD:143166	24/131 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810