DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and TNKS

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_003738.2	Gene:	TNKS / 8658	HGNCID:	11941	Length:	1327	Species:	Homo sapiens

Alignment Length:	773	Identity:	181/773 - (23%)
Similarity:	291/773 - (37%)	Gaps:	148/773 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 DAAAEAAVDVPET----DPDPAQLTVSQSQSSSTVARRRLAEGCT------SLMYACQRGDIVQV 139
            :||::..|:|...    ..||..:......:........|.|..|      ||:.|.:..|:.:|
Human   441 EAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKV 505

  Fly   140 LAQMREKPELLR-QRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLESADEDGFTPLHLA 203
            ...:  ..|::. ::.:||..||| ||.......:..|....:...|.  :...::|..||||:|
Human   506 KKTL--ALEIINFKQPQSHETALH-CAVASLHPKRKQVTELLLRKGAN--VNEKNKDFMTPLHVA 565

  Fly   204 VIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPDANGGTPLHY 268
            ..:.:..::.:|..:.|.:||:|..|.:.:|.|.:.|.:::.|.:|:.|:..:.....|.|
Human   566 AERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT---- 626

  Fly   269 AAQMCGASKQDSKQQASSSNSSRLSLEIL-----GILLSHPQ----SSVDVQDKDGRQ--PLLWA 322
            ||||...:.|....:::...:|.:...:|     |.|.:..|    .:|:.:|.:||.  ||.:|
Human   627 AAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFA 691

  Fly   323 ASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSNGCTALH 387
            |.......|..|:..||.|.:.||.||..||.|.|.||.|..:.|: ..||..::.|....|.||
Human   692 AGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLV-RHGASVNVADLWKFTPLH 755

  Fly   388 YAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGA------------- 439
            .|...|..:....||...|||.:::|.|.||... ..:|..:...||:...|
Human   756 EAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRGDAALLDAAKKGCLARV 819

  Fly   440 -------NLWLRNAKG--DLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYT 495
                   |:..|:.:|  ..|||.||.....|:.|:|| :....||.....|...||.||:..:.
Human   820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLL-EHGADVNAQDKGGLIPLHNAASYGHV 883

  Fly   496 DMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRSTAKFLQANGGQPANKVRLSSRRTGNPF 560
            |:..||:.|...|||..:    ...|||..|.|:|.......|.|:|..|..|    ::....|.
Human   884 DIAALLIKYNTCVNATDK----WAFTPLHEAAQKGRTQLCALLLAHGADPTMK----NQEGQTPL 940

  Fly   561 HETNATDM----------------VRPLKYVEKEELHDLRSSKKYVVYLKRSDSDNG-----NEN 604
            ....|.|:                .:|...|....|....|:...:......|:..|     ...
Human   941 DLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVG 1005

  Fly   605 GKADVGDGDCSCSEQTYRKE-----------QRLRHVCRRHKRRQLRRRTSS---CGESKHERCS 655
            |.::.|||    :..|.|||           |.|:.:...|.|........:   ..:..||...
Human  1006 GASNAGDG----AAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELK 1066

  Fly   656 EICRSKSNIEIRRRKSRERYASSSEW------------------------EEESAEDSCENCC-- 694
            ||..:......:..|..||.....:.                        |.:|.|:..::..
Human  1067 EIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIRE 1131

  Fly   695 -------------YHKRQKDRVVNRK-RSTSSRKSKNRDSSDPDEKNHSEN---HSSP 735
                         |:..:..:|||:| |.....:.|  :.|:.:..:|:|.   |.||
Human  1132 HRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQK--EVSEENHNHHNERMLFHGSP 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	24/99 (24%)
		ANK	193..335	CDD:238125	39/152 (26%)
		ANK repeat	195..226	CDD:293786	10/30 (33%)
		Ank_5	214..269	CDD:290568	14/54 (26%)
		ANK repeat	228..259	CDD:293786	7/30 (23%)
		ANK repeat	314..345	CDD:293786	11/32 (34%)
		Ank_2	319..412	CDD:289560	33/92 (36%)
		ANK	345..468	CDD:238125	43/144 (30%)
		ANK repeat	347..379	CDD:293786	12/31 (39%)
		ANK repeat	381..412	CDD:293786	10/30 (33%)
		ANK	409..538	CDD:238125	40/150 (27%)
		ANK repeat	414..479	CDD:293786	21/86 (24%)
		ANK repeat	419..445	CDD:293786	5/45 (11%)
		Ank_2	420..511	CDD:289560	29/112 (26%)
		ANK repeat	481..511	CDD:293786	11/29 (38%)
		Ank_2	486..>545	CDD:289560	20/58 (34%)
		ANK repeat	516..542	CDD:293786	8/25 (32%)
TNKS	NP_003738.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..173
		ANK 1. /evidence=ECO:0000255	181..209
		ANK	208..322	CDD:238125
		ANK 2. /evidence=ECO:0000255	215..244
		ANK repeat	218..246	CDD:293786
		Ank_2	220..312	CDD:289560
		ANK repeat	248..279	CDD:293786
		ANK 3. /evidence=ECO:0000255	248..277
		ANK	276..455	CDD:238125	4/13 (31%)
		ANK repeat	281..312	CDD:293786
		ANK 4. /evidence=ECO:0000255	281..310
		ANK 5. /evidence=ECO:0000255	335..364
		Ank_4	339..389	CDD:290365
		ANK 6. /evidence=ECO:0000255	368..397
		ANK repeat	371..399	CDD:293786
		Ank_2	373..465	CDD:289560	6/23 (26%)
		ANK repeat	401..432	CDD:293786
		ANK 7. /evidence=ECO:0000255	401..430
		ANK repeat	434..465	CDD:293786	6/23 (26%)
		ANK 8. /evidence=ECO:0000255	434..463		6/21 (29%)
		ANK 9. /evidence=ECO:0000255	521..553		9/34 (26%)
		ANK	523..639	CDD:238125	32/122 (26%)
		ANK repeat	523..555	CDD:293786	7/34 (21%)
		Ank_2	526..619	CDD:289560	24/95 (25%)
		ANK repeat	557..588	CDD:293786	10/30 (33%)
		ANK 10. /evidence=ECO:0000255	557..586		8/28 (29%)
		ANK repeat	590..619	CDD:293786	7/28 (25%)
		ANK 11. /evidence=ECO:0000255	590..619		7/28 (25%)
		Ank_2	595..714	CDD:289560	31/122 (25%)
		ANK 12. /evidence=ECO:0000255	621..647		7/29 (24%)
		ANK 13. /evidence=ECO:0000255	649..679		5/29 (17%)
		ANK	676..801	CDD:238125	42/126 (33%)
		ANK 14. /evidence=ECO:0000255	683..712		10/28 (36%)
		ANK repeat	686..714	CDD:293786	9/27 (33%)
		Ank_2	688..780	CDD:289560	33/92 (36%)
		ANK repeat	716..747	CDD:293786	12/31 (39%)
		ANK 15. /evidence=ECO:0000255	716..745		12/29 (41%)
		ANK repeat	749..780	CDD:293786	10/30 (33%)
		ANK 16. /evidence=ECO:0000255	749..778		10/28 (36%)
		ANK 17. /evidence=ECO:0000255	782..810		7/28 (25%)
		Ank_4	803..857	CDD:290365	11/53 (21%)
		ANK	829..953	CDD:238125	39/132 (30%)
		ANK repeat	836..867	CDD:293786	11/31 (35%)
		ANK 18. /evidence=ECO:0000255	836..865		10/29 (34%)
		Ank_2	841..933	CDD:289560	33/100 (33%)
		ANK repeat	869..900	CDD:293786	12/30 (40%)
		ANK 19. /evidence=ECO:0000255	869..898		10/28 (36%)
		ANK repeat	902..933	CDD:293786	11/34 (32%)
		ANK 20. /evidence=ECO:0000255	902..931		10/28 (36%)
		ANK 21. /evidence=ECO:0000255	935..964		3/28 (11%)
		SAM_tankyrase1,2	1024..1089	CDD:188923	11/64 (17%)
		SAM	1030..1087	CDD:197735	11/56 (20%)
		tankyrase_like	1091..1313	CDD:238718	16/99 (16%)
		PARP	1105..1308	CDD:279038	16/85 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910