DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and HOS4

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_012154.1	Gene:	HOS4 / 854694	SGDID:	S000001374	Length:	1083	Species:	Saccharomyces cerevisiae

Alignment Length:	1032	Identity:	216/1032 - (20%)
Similarity:	359/1032 - (34%)	Gaps:	332/1032 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ESPLPRRT--------RTMQQQQQQDNDHPPQQEKQ---EQQQQQQQRQEAADKVIAMPGS--SQ 82
            :.||.:|:        .|.:::.::.:.....:|:.   :.:|::...:|.:||......|  ||
Yeast     7 KQPLKKRSLSSYLSNVSTRREELEKISKQETSEEEDTAGKHEQRETLSEEVSDKFPENVASFRSQ 71

  Fly    83 DT----------------------DAAA-EAAV-------DVPETDPDPAQ---LTVSQSQSSST 114
            .|                      ||:: |..|       |||||:...:|   ..:|.|.||..
Yeast    72 TTSVHQATQNNLNAKESEDLAHKNDASSHEGEVNGDSRPDDVPETNEKISQAIRAKISSSSSSPN 136

  Fly   115 V-----------ARRRL-----------------AEGCTSLMYACQRGDIV-QVLAQMREKPELL 150
            |           :|.:|                 .||    :.|.:..|:. :||.:...:||.:
Yeast   137 VRNVDIQNHQPFSRDQLRAMLKEPKRKTVDDFIEEEG----LGAVEEEDLSDEVLEKNTTEPENV 197

  Fly   151 RQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLESADEDGFTPLHLA---VIQGNL--A 210
             ::|      :.|     |:..||.....|....||.          :|:.|.   :::|:.  |
Yeast   198 -EKD------IEY-----SDSDKDTDDVGSDDPTAPN----------SPIKLGRRKLVRGDQLDA 240

  Fly   211 MVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPDANGGTPLHYAAQMCGA 275
            ..:.:..|::|....|.:....:          :|.:.|..|.|....:.|..     .:.|..:
Yeast   241 TTSSMFNNESDSELSDIDDSKNI----------ALSSSLFRGGSSPVKETNNN-----LSNMNSS 290

  Fly   276 SKQDSKQ-QASSSNSSRLSLEILGILLSHPQSSVDV-QDKDGRQPLLWAASAGSAKAVIALVKAG 338
            ..|:.|: ..|.||.|..|..|  .:...|:....: :|..||..|..|...|....|..:::.|
Yeast   291 PAQNPKRGSVSRSNDSNKSSHI--AVSKRPKQKKGIYRDSGGRTRLQIACDKGKYDVVKKMIEEG 353

  Fly   339 A-RVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDL--IDSNGCTALHYAVTLGHADATAR 400
            . .:...|..|.||||.|..:||.|.::.||. .||..::  |:..|.|.|..|...||.|....
Yeast   354 GYDINDQDNAGNTALHEAALQGHIEIVELLIE-NGADVNIKSIEMFGDTPLIDASANGHLDVVKY 417

  Fly   401 LLDLEADPNRQDRKGRTPAHCGCSKGQF---ETLKLLKE------RGANLW-----LRNAKG--- 448
            ||...|||..::.||.|.......:.:|   |..|:|:|      ..|..|     :.|.|.
Yeast   418 LLKNGADPTIRNAKGLTAFESVDDESEFDDEEDQKILREIKKRLSIAAKKWTNRAGIHNDKSKNG 482

  Fly   449 ------DLPLHEAAASGRRE-------LLEWLLAQRPKQ----VNTTSNDGRSLL-------HIA 489
                  |.|..:.....:.|       :...:..:.|::    .:.||..|:..|       |:.
Yeast   483 NNAHTIDQPPFDNTTKAKNEKAADSPSMASNIDEKAPEEEFYWTDVTSRAGKEKLFKASKEGHLP 547

  Fly   490 AANDYT--------------------DMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRST 534
            ....|.                    |:..:.|.:|..||...|:::   .:.|..|:.|||..|
Yeast   548 YVGTYVENGGKIDLRSFFESVKCGHEDITSIFLAFGFPVNQTSRDNK---TSALMVAVGRGHLGT 609

  Fly   535 AKFLQANGGQPANKVRLSSRRTGNPFHETNATDMVRPLKYVEKEELHDLRSSKKYVV-------Y 592
            .|.|...|..|..:.:..                 |...|..|..:..:.:|::..:       |
Yeast   610 VKLLLEAGADPTKRDKKG-----------------RTALYYAKNSIMGITNSEEIQLIENAINNY 657

  Fly   593 LKRSDSDNGNENGKADVGDGDCSCSEQTYRKEQRLRHVCRRHKRRQLRRRTSSCGESKHERCSEI 657
            ||:...||.::       |.|...:.:||                            |||:..|
Yeast   658 LKKHSEDNNDD-------DDDDDNNNETY----------------------------KHEKKRE- 686

  Fly   658 CRSKSNIEIRRRKSRERYASSSEWEEES------AEDSCENCCYHKRQKDRVVNRKRSTSSRKSK 716
             :::|.|...||.:..|.    |.||:.      |:|...|        ||.|  |.||:|...|
Yeast   687 -KTQSPILASRRSATPRI----EDEEDDTRMLNLADDDFNN--------DRDV--KESTTSDSRK 736

  Fly   717 NRDSSDPDEKNHSENHSSPEKGSRKPLAVNGDHQADNGKDQTSTKERPPSASRHQTPPTKEGTFI 781
            ..|    |.:|....:|...| .||..|:         :|:...|...|.:....:|
Yeast   737 RLD----DNENVGTQYSLDWK-KRKTNAL---------QDEEKLKSISPLSMEPHSP-------- 779

  Fly   782 KSPTQSAKSEKSGQMDNLLVEESHAVELTDEEQEAAKSVVTQVDVHHDAEEIQTSKSSEEAPQAE 846
                :.|||          ||.|...|.|..|:||...           ||.:..|...|
Yeast   780 ----KKAKS----------VEISKIHEETAAEREARLK-----------EEEEYRKKRLE----- 814

  Fly   847 ENGKEKESEQEVKLQLSEEETQLVSKEVEQVII---IAATALSSESKSSSEEKSVEK 900
               |:::.|||:..:|:|:|.:.:.::.:|.::   ....|...:::....||.:|:
Yeast   815 ---KKRKKEQELLQKLAEDEKKRIEEQEKQKVLEMERLEKATLEKARKMEREKEMEE 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	20/104 (19%)
		ANK	193..335	CDD:238125	29/148 (20%)
		ANK repeat	195..226	CDD:293786	6/35 (17%)
		Ank_5	214..269	CDD:290568	8/54 (15%)
		ANK repeat	228..259	CDD:293786	4/30 (13%)
		ANK repeat	314..345	CDD:293786	7/31 (23%)
		Ank_2	319..412	CDD:289560	32/95 (34%)
		ANK	345..468	CDD:238125	42/154 (27%)
		ANK repeat	347..379	CDD:293786	13/33 (39%)
		ANK repeat	381..412	CDD:293786	12/30 (40%)
		ANK	409..538	CDD:238125	35/189 (19%)
		ANK repeat	414..479	CDD:293786	16/98 (16%)
		ANK repeat	419..445	CDD:293786	7/39 (18%)
		Ank_2	420..511	CDD:289560	24/151 (16%)
		ANK repeat	481..511	CDD:293786	9/56 (16%)
		Ank_2	486..>545	CDD:289560	18/85 (21%)
		ANK repeat	516..542	CDD:293786	8/25 (32%)
HOS4	NP_012154.1	ANK repeat	330..361	CDD:293786	7/30 (23%)
		Ank_2	334..429	CDD:403870	32/95 (34%)
		ANK repeat	363..396	CDD:293786	13/33 (39%)
		ANK repeat	398..429	CDD:293786	12/30 (40%)
		Ank_2	537..624	CDD:403870	19/89 (21%)
		ANK repeat	592..624	CDD:293786	10/34 (29%)
		Ank_2	598..>656	CDD:403870	14/74 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
TreeFam	0	0.000	Not matched by this tool.
	1	1.000