DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and Mib2

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_006539310.1	Gene:	Mib2 / 76580	MGIID:	2679684	Length:	982	Species:	Mus musculus

Alignment Length:	500	Identity:	134/500 - (26%)
Similarity:	208/500 - (41%)	Gaps:	82/500 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 PETDPDPAQLTVSQ------SQSSSTVARRRLAEGCTSLMYACQRGDIVQVLAQMREKPELLRQR 153
            ||.|   |.|.|::      |.:|.:||..|......:|......|.:...|.::|     .::.
Mouse   397 PEED---ANLDVAERARENKSAASVSVAGGRQGSPWPALTSTLPPGSLSVALDKLR-----TQKS 453

  Fly   154 DRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLESADEDGFTPLHLAVIQGNLAMVNLLLAN 218
            |..|...|...||..     ::..|..:....||.:::.:: |.|.|.:|...|.:.:|.|||..
Mouse   454 DPEHPGRLVVEAALG-----NVARALDLLRRHPEQVDTKNQ-GRTALQVAAYLGQVELVRLLLQA 512

  Fly   219 KADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQ 283
            :|.::..|:||::|:|:..:..:.|:.|.:|:||.:|...:....|.||.|.|
Mouse   513 RASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCAVDARNGTRSTALHVAVQ------------ 565

  Fly   284 ASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKA---GARVESSD 345
                   |..||::.||... ...|::.|.....||..|.|||:..:.|..|..   |..|.:::
Mouse   566 -------RGFLEVVKILCER-GCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATN 622

  Fly   346 KDGLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSNGCTALHYAVTLGHADATARLL-DLEADPN 409
            ..|.|.||.|..:||...:..::.......|....:|.||||.|....|.:....|: :...|.|
Mouse   623 SQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVN 687

  Fly   410 RQDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQR--- 471
            .::||.::|.|....:.....:.||.:.|.::...:.:||..||  .|..|.:||. |:|.|
Mouse   688 VRNRKLQSPLHLAVQQAHLGLVPLLVDAGCSVNTEDEEGDTALH--VALQRHQLLP-LVADRAGG 749

  Fly   472 ---PKQ----VNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSR----------GLV 519
               |.|    :..:...|.:.|.:.||    ..|.|.|: ||||:  |.|.|          |.|
Mouse   750 DPGPLQLLSRLQASGLPGCTELTVGAA----VACFLALE-GADVS--YANHRGRSPLDLATEGRV 807

  Fly   520 LTPLDGALQRGHRSTAKFLQANGG---QPANKVRLSSRRTGNPFH 561
            |..|.|..||....     ||.||   .|..:..||:..|....|
Mouse   808 LKALQGCAQRFRER-----QAGGGGGVPPGPRHVLSTPNTVTNLH 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	22/98 (22%)
		ANK	193..335	CDD:238125	40/141 (28%)
		ANK repeat	195..226	CDD:293786	10/30 (33%)
		Ank_5	214..269	CDD:290568	18/54 (33%)
		ANK repeat	228..259	CDD:293786	10/30 (33%)
		ANK repeat	314..345	CDD:293786	10/33 (30%)
		Ank_2	319..412	CDD:289560	27/96 (28%)
		ANK	345..468	CDD:238125	33/123 (27%)
		ANK repeat	347..379	CDD:293786	8/31 (26%)
		ANK repeat	381..412	CDD:293786	10/31 (32%)
		ANK	409..538	CDD:238125	42/148 (28%)
		ANK repeat	414..479	CDD:293786	19/74 (26%)
		ANK repeat	419..445	CDD:293786	4/25 (16%)
		Ank_2	420..511	CDD:289560	28/100 (28%)
		ANK repeat	481..511	CDD:293786	11/29 (38%)
		Ank_2	486..>545	CDD:289560	24/71 (34%)
		ANK repeat	516..542	CDD:293786	10/35 (29%)
Mib2	XP_006539310.1	MIB_HERC2	12..77	CDD:369043
		ZZ_Mind_bomb	89..133	CDD:239079
		MIB_HERC2	160..224	CDD:369043
		SH3_15	257..322	CDD:375773
		SH3_15	328..392	CDD:375773
		PLN03192	<453..517	CDD:215625	18/69 (26%)
		PHA03095	486..>737	CDD:222980	73/273 (27%)
		ANK repeat	490..520	CDD:293786	10/29 (34%)
		ANK repeat	522..553	CDD:293786	10/30 (33%)
		ANK repeat	555..586	CDD:293786	11/50 (22%)
		ANK repeat	588..622	CDD:293786	10/33 (30%)
		ANK repeat	625..656	CDD:293786	8/30 (27%)
		ANK repeat	658..690	CDD:293786	10/31 (32%)
		ANK repeat	692..723	CDD:293786	6/30 (20%)
		RING1-HC_MIB2	858..894	CDD:319640
		RING_Ubox	937..982	CDD:388418
		RING-HC finger (C3HC4-type)	938..970	CDD:319361
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000