DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and ank2a

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_021331690.1	Gene:	ank2a / 568926	ZFINID:	ZDB-GENE-111215-3	Length:	4856	Species:	Danio rerio

Alignment Length:	1389	Identity:	296/1389 - (21%)
Similarity:	457/1389 - (32%)	Gaps:	450/1389 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AEVKRVRGPAKPPRLKAAKKQLQFESPLPRRTRTMQQQQQQDNDHPPQQEKQEQQQQQQQRQEAA 71
            |.:|:.|...:||.:||..|..:      ||.|           |..:.|::.:.........||
Zfish     6 AHLKKARELEQPPEIKALAKARE------RRRR-----------HKERAERKRKSDSNTSFLRAA 53

  Fly    72 -----DKVIAMPGSSQDTD------------AAAEAAVDVPETDPDPAQLTVSQSQSSSTVARRR 119
                 :||:....|.||..            ||.|..|::.|     ..|....:..|||
Zfish    54 RAGNIEKVLEFLKSGQDISTCNQNGLNALHLAAKEGHVELVE-----ELLERGAAVDSST----- 108

  Fly   120 LAEGCTSLMYACQRGDIVQVLAQMREKPELLRQR----DRSHRNALH--YCAAQDSEGSKDLVAA 178
             .:|.|:|..||        ||..:|..:||.::    :...:|...  |.|||  |...|:|.
Zfish   109 -KKGNTALHIAC--------LAGQKEVAKLLVKKTADVNSQSQNGFTPLYMAAQ--ENHLDVVR- 161

  Fly   179 ASIAIAAPELLES------ADEDGFTPLHLAVIQGNLAMVNLLL----------------ANKAD 221
                    .|||:      |.|||||||.:|:.||:..:|:|||                |.|.|
Zfish   162 --------YLLENGGNQSMATEDGFTPLAIALQQGHNQVVSLLLEHDTKGKVRLPALHIAARKDD 218

  Fly   222 ---------------------VNAVDNEGHS---VVHWATVCGEVESLRAVLAAGASVAKPDANG 262
                                 ||.....|.|   .:|.|...|.|.....:|..||:|.....||
Zfish   219 TKSAALLLQNDHNADVQSKMMVNRTTENGKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 283

  Fly   263 GTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGS 327
            .||||.|                   |.|.:..::.:||.. .|.:|.:.:||..||..||.:|.
Zfish   284 ITPLHVA-------------------SKRGNTNMIALLLDR-GSQIDAKTRDGLTPLHCAARSGH 328

  Fly   328 AKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSNGCTALHYAVTL 392
            ..||..|::.||.:.:..|:||:.||.:....|.||:..|: ...||.|.:..:..||||.|...
Zfish   329 DSAVEILLEKGAPILARTKNGLSPLHMSAQGDHVECVKHLL-QHKAPVDDVTLDYLTALHVAAHC 392

  Fly   393 GHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAA 457
            ||...|..|||.:|:||.:...|.||.|..|.|.:.:.::||.:.||::......|..|:|.:|.
Zfish   393 GHYRVTKLLLDKKANPNARALNGFTPLHIACKKNRVKVMELLVKYGASIQAITESGLTPIHVSAF 457

  Fly   458 SGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTP 522
            .|...:: .||.|.....:..:..|.:.||:||.....::.:.||..||.|:|:.|..:    ||
Zfish   458 MGHLNIV-LLLLQNGASPDVCNIRGETALHMAARAGQMEVVRCLLRNGALVDAMAREDQ----TP 517

  Fly   523 LDGALQRGHRSTAKFLQANGGQPANKVRLSSRRTG-NPFH--------ETNATDMVRPLKYVEKE 578
            |..|.:.|.....:.|..:...|.     :|...| .|.|        ||.|.       .:|..
Zfish   518 LHIASRLGQTEIVQLLLQHMAHPD-----ASTTNGYTPLHISAREGQVETAAV-------LLEAG 570

  Fly   579 ELHDLRSSK---------KY-------VVYLKRSDSDNGNENGKADVGDGDCSCSEQTYRKEQRL 627
            ..|.|.:.|         ||       ::..:|:..|:..:.|...:
Zfish   571 ASHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRALLDDAGKYGLTPL------------------ 617

  Fly   628 RHVCRRHKRRQLRRRTSSCGESKHERCSEICRSKSNIEIRRRKSRERYAS--------------- 677
             ||...:..:|:.......|.|.|....   ...:.:.|..:|::.:.||
Zfish   618 -HVAAHYDNQQVALMLLDKGASPHATAK---NGYTPLHIAAKKNQTQIASALLQYGAETNALTKQ 678

  Fly   678 --------SSEWEEESA--------------------------ED---SCENCCYHKRQKD---- 701
                    |.|...|.|                          ||   :.|....|....|
Zfish   679 GVSPLHLASQEGHTEMAALLLERGAHVNAATKSGLTPLHLTAQEDRVQAAEILAKHDANIDQQTK 743

  Fly   702 ---------------RVVN---RKRSTSSRKSKNRDSSDPDEKNHSENHSSPEKGSRKPLAVNGD 748
                           ::||   :..:..:.|:||         .::..|.:.::|:...:.|...
Zfish   744 LGYTPLIVACHYGNVKMVNFLLQNGANVNGKTKN---------GYTPLHQAAQQGNTHIVNVLLQ 799

  Fly   749 HQAD------NGKDQTSTKERPPSASRHQTPPTKEGTFIKSPTQSAKSEKSGQMDNLLVEESHAV 807
            |.|.      ||....|..:|....|...|........|.:.|...:..|....:.:    :..:
Zfish   800 HGAKPNAVTMNGNTALSIAKRLGYISVVDTLKVVTEEIITTTTTVTEKHKLNVPETM----TEVL 860

  Fly   808 ELTDEE--QEAAKSVVTQVDVHHDAEEIQTSKSSE--EAPQAEENGKEKESEQEV-------KLQ 861
            :::|||  .:..:.:.|:|.:..:.|:..|....|  .|....|.|.:......:       .|.
Zfish   861 DVSDEEAQHQTEEELFTEVYMEIEGEDTMTGDGGEYLRAEDLRELGDDSLPGHYLDGMSYTHNLD 925

  Fly   862 LSEEETQLVSKEVEQVII---IAATALSSESKSSSEEKS---------------VEKELPKEGQA 908
            .|.|....::...|.::|   ||:..::..|.....||.               :...|.:.||:
Zfish   926 RSHETPSHLAYRGEGILIEDMIASHQINKVSAFREHEKDSYRLSWGAEHLDNVVLTSTLLQSGQS 990

  Fly   909 -PGENHDEEV----------------KEHQN-----PPTPYAPPAQPSTPPPPPKEEAAKPPSAA 951
             |..:||...                ..|..     ||...:.|.:.:.........|:.||
Zfish   991 TPCLDHDNSSFLVSFMVDARGGAMRGCRHNGLRIIVPPRKCSAPTRVTCRLVKRHRLASMPP--- 1052

  Fly   952 EQPQPNANTVEGMESAAAEPASVGKKTEQMELAEAKPKPNTNPT------PIPPPTAAPP----- 1005
                    .||| |..|.:...||                  ||      .:..|||.||
Zfish  1053 --------MVEG-EGLAGKIIEVG------------------PTGAQFLGKLHLPTAPPPLNEGE 1090

  Fly  1006 ---------GPPSAESKKPPAAPQPRPSTPQTPTPPQPEPPQREQETRRSFTLLPSDSADD---- 1057
                     |||..:...|.....|..:.              .:.|.|...:|.|::.:.
Zfish  1091 SLVSRILQLGPPGTKFLGPVIVEIPHFAA--------------LRGTERELVILRSETGESWREH 1141

  Fly  1058 ---------DPVLN---PNSNPPAS----------ASDEP-----AGERKSSFHVLKSDDSLDES 1095
                     :.:||   ...:||..          ..|.|     ....|...|::..:..:..|
Zfish  1142 HCEHTEEELNQILNGMDEELDPPEELEKKRICRLITRDFPQYFAVVSRIKQDSHLIGPEGGVLSS 1206

  Fly  1096 TKRPGRKVDYEAGNQVFQVVGEGA 1119
            |..|          ||..|..|||
Zfish  1207 TLVP----------QVQAVFPEGA 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	39/147 (27%)
		ANK	193..335	CDD:238125	51/181 (28%)
		ANK repeat	195..226	CDD:293786	18/67 (27%)
		Ank_5	214..269	CDD:290568	24/94 (26%)
		ANK repeat	228..259	CDD:293786	10/33 (30%)
		ANK repeat	314..345	CDD:293786	12/30 (40%)
		Ank_2	319..412	CDD:289560	35/92 (38%)
		ANK	345..468	CDD:238125	41/122 (34%)
		ANK repeat	347..379	CDD:293786	11/31 (35%)
		ANK repeat	381..412	CDD:293786	14/30 (47%)
		ANK	409..538	CDD:238125	36/128 (28%)
		ANK repeat	414..479	CDD:293786	18/64 (28%)
		ANK repeat	419..445	CDD:293786	7/25 (28%)
		Ank_2	420..511	CDD:289560	25/90 (28%)
		ANK repeat	481..511	CDD:293786	10/29 (34%)
		Ank_2	486..>545	CDD:289560	17/58 (29%)
		ANK repeat	516..542	CDD:293786	6/25 (24%)
ank2a	XP_021331690.1	ANK	<40..98	CDD:238125	12/62 (19%)
		ANK repeat	44..75	CDD:293786	7/30 (23%)
		ANK	74..197	CDD:238125	43/152 (28%)
		ANK repeat	77..108	CDD:293786	7/35 (20%)
		ANK repeat	110..141	CDD:293786	10/38 (26%)
		ANK repeat	143..168	CDD:293786	11/35 (31%)
		Ank_4	206..270	CDD:316185	11/63 (17%)
		ANK repeat	209..236	CDD:293786	3/26 (12%)
		ANK	248..369	CDD:238125	42/140 (30%)
		ANK repeat	249..280	CDD:293786	9/30 (30%)
		ANK repeat	282..313	CDD:293786	13/50 (26%)
		ANK	310..435	CDD:238125	46/125 (37%)
		ANK repeat	315..346	CDD:293786	12/30 (40%)
		ANK repeat	348..379	CDD:293786	11/31 (35%)
		ANK repeat	381..411	CDD:293786	14/29 (48%)
		ANK	409..534	CDD:238125	36/129 (28%)
		ANK repeat	414..445	CDD:293786	10/30 (33%)
		ANK repeat	447..478	CDD:293786	8/31 (26%)
		ANK	475..600	CDD:238125	32/140 (23%)
		ANK repeat	480..511	CDD:293786	11/30 (37%)
		ANK repeat	513..542	CDD:293786	7/37 (19%)
		ANK repeat	546..571	CDD:293786	7/31 (23%)
		ANK	578..699	CDD:238125	20/142 (14%)
		ANK repeat	579..607	CDD:293786	4/27 (15%)
		ANK repeat	612..643	CDD:293786	7/49 (14%)
		ANK repeat	645..676	CDD:293786	4/30 (13%)
		ANK	673..798	CDD:238125	17/133 (13%)
		ANK repeat	678..707	CDD:293786	4/28 (14%)
		ANK repeat	711..742	CDD:293786	5/30 (17%)
		ANK repeat	744..775	CDD:293786	2/30 (7%)
		ANK repeat	777..807	CDD:293786	6/38 (16%)
		Ank_4	778..830	CDD:316185	10/51 (20%)
		ZU5	999..1136	CDD:128514	30/180 (17%)
		DD	3434..3517	CDD:326335
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910