DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and espnlb

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_017207109.1	Gene:	espnlb / 566645	ZFINID:	ZDB-GENE-070912-481	Length:	1005	Species:	Danio rerio

Alignment Length:	921	Identity:	201/921 - (21%)
Similarity:	321/921 - (34%)	Gaps:	245/921 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 ACQRGDIVQVLAQMREKPELLRQRDRSHRNALHY--CAA---QDSEGSKDL-VAAASIAIAAPEL 188
            |.:.||:           |.||        |||.  |.:   .|::|:..: .||.:..:...|.
Zfish     9 AAREGDV-----------EALR--------ALHVSGCLSPTITDAQGASPVHHAARNGQLDCLEF 54

  Fly   189 L--------ESADEDGFTPLHLAVIQGNLAMVNLLLANK-ADVNAVDNEGHSVVHWATVCGEVES 244
            |        .:..::|.|..|.|...|::..:..||..: ..:...|.||.:.:|.|...|..|:
Zfish    55 LVHEGYFQCNTRTKNGATAAHDAAATGHIRELQWLLKQETCGIEDRDGEGATALHLAARFGHAEA 119

  Fly   245 LRAVLAAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVD 309
            ::.:|..|.:.......|..|:||||             ||...:|      |.:|:|.....||
Zfish   120 VQWLLFEGGNTEAETDCGARPVHYAA-------------ASGDLTS------LKMLMSSSPRCVD 165

  Fly   310 VQDKDGRQPLLWAASAGSAKAVIALVK-AGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGA 373
            .|...|..||..|...|....|..||| .||.|....|||::.||.|...||...:..|......
Zfish   166 CQTGTGATPLYLACQEGHLHVVEYLVKDCGANVHVQAKDGMSVLHAAAHMGHYALVVWLASFTDL 230

  Fly   374 PTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERG 438
            .....|.||.||||:|.:.||.....|||                         ...:|:||:.
Zfish   231 DLSCQDKNGATALHFAASEGHHRIVERLL-------------------------LMGVKVLKDH- 269

  Fly   439 ANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLD 503
               |     |..|||:||.:|..|....||......:...| ||.:.||:|..|.|.|....|.|
Zfish   270 ---W-----GGTPLHDAAENGELECCRVLLNNHISPLERDS-DGFTALHLAEYNGYHDCANFLRD 325

  Fly   504 YGADVN---AVYRNSRGLVLT--PLDGALQRGHRSTAKFLQANGGQPANKVRLSSRRT------- 556
            .||..:   .:....|.|..|  |........|:|..:..     :|.|:|....|.:
Zfish   326 AGAQQSPDIVLIEEERTLFSTADPYQDIEDLKHKSKMEIC-----KPVNEVSPQPRPSPACLETS 385

  Fly   557 --------------GNPFHETNATDMVRPL---KYVEKEE-------LHDLRSSKKYVVYLKRSD 597
                          |...|...|:.:|...   |::|:||       :..:|.:....|:..:::
Zfish   386 STLLDSSQAKKAGAGTIQHMQVASTVVTSFNMRKHLEEEEAMLSHKSMRSMRQAGITAVFTGQTN 450

  Fly   598 SDNGNENGKADVGD--------GDCSCSEQTYRKEQR-LRHVCRRHKRRQLRRRTSSCGESKHER 653
            ...| ||   |:|.        .|......|:.:..| :....|:...|:|:.|...  |..|.:
Zfish   451 VQKG-EN---DIGPLVTLEANLADIDSLIPTHDENGRPIAEWKRQVMVRKLQARLQD--EDDHSK 509

  Fly   654 CSEICRSKSNIEIRR-RKSRERYASSSEWEEESAEDSC-------------ENCCYHKRQKDR-- 702
            ..||  |..:||:.. |.|:........:.|...||..             :.|..::.:..|
Zfish   510 KQEI--SGKHIEVDGWRYSQVHNVILGPFGELLTEDDLVYLEGQIETISLQKRCQAYELELARLA 572

  Fly   703 ----------VVNRKRSTSSRKSKNRDSSDPDE-----------------KNHSENHSSPEKG-- 738
                      :||...:|...:..|.:.|.|..                 .|.||  :|.|.|
Zfish   573 EELRAILPAPIVNITVNTQCPQLPNMEESLPLPVWYNRISNIVKSMSLLLTNLSE--TSGEDGIC 635

  Fly   739 --SRKPLAVNGDHQADNGKDQTSTKERPPSASRHQTPPTKEGTFIKSPTQSAKSE------KSGQ 795
              ..|.||....:|.:.   |:|.:.|   ..:.:....:.|..:::...:.:|:      .||.
Zfish   636 KMPNKDLASVFTYQPER---QSSIRGR---RQKVELEIQQSGVSVRNLRSNFESQIGNIYPFSGL 694

  Fly   796 MDNLLVEESHAVELTDEEQEAAKSVVTQVDVHHDAEEIQTSKSSEEAPQAEENGKEKESEQEVKL 860
            ::|........:..:....|.....:...|::|..:   ::...::||          |....|:
Zfish   695 LNNTCDTRQQKLSTSTNGCEQPMGTIQSTDINHLHD---SAIKCQQAP----------SRDAAKV 746

  Fly   861 QLSEEETQLVSKEVEQVIIIAATALSSESKSSSEEKSVEKELPKE-GQAPGENHDEEVKEHQNPP 924
            .    ||..:.|  |:::::    ..|..|.|:...|:..::.:| |...||...
Zfish   747 M----ETTCLRK--ERIVVL----FLSHWKRSAYAISLRAKMKQELGTLTGEGIT---------- 791

  Fly   925 TPYAPPAQPST 935
               ||.::|.|
Zfish   792 ---APVSKPGT 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	23/110 (21%)
		ANK	193..335	CDD:238125	37/142 (26%)
		ANK repeat	195..226	CDD:293786	7/31 (23%)
		Ank_5	214..269	CDD:290568	14/55 (25%)
		ANK repeat	228..259	CDD:293786	8/30 (27%)
		ANK repeat	314..345	CDD:293786	12/31 (39%)
		Ank_2	319..412	CDD:289560	32/93 (34%)
		ANK	345..468	CDD:238125	34/122 (28%)
		ANK repeat	347..379	CDD:293786	8/31 (26%)
		ANK repeat	381..412	CDD:293786	12/30 (40%)
		ANK	409..538	CDD:238125	33/133 (25%)
		ANK repeat	414..479	CDD:293786	14/64 (22%)
		ANK repeat	419..445	CDD:293786	4/25 (16%)
		Ank_2	420..511	CDD:289560	27/93 (29%)
		ANK repeat	481..511	CDD:293786	12/32 (38%)
		Ank_2	486..>545	CDD:289560	16/63 (25%)
		ANK repeat	516..542	CDD:293786	6/27 (22%)
espnlb	XP_017207109.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000