DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and tnksa

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_009293648.1	Gene:	tnksa / 559022	ZFINID:	ZDB-GENE-030131-7450	Length:	1259	Species:	Danio rerio

Alignment Length:	1057	Identity:	237/1057 - (22%)
Similarity:	381/1057 - (36%)	Gaps:	284/1057 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RTMQQQQQQDNDHPPQQEKQEQQQQQQQRQEAADKVIAMPGSSQDTD---AAAEA-AVDVPETDP 99
            ||.||||||.|...||:.....              ::.|.|..||.   |..|| ::..||...
Zfish     6 RTAQQQQQQQNLSSPQRPDSSP--------------LSPPESPTDTGGLAAGGEAESIGDPELSA 56

  Fly   100 D-PAQL--TVSQSQSSSTVARRRL------------------AEGC-TS-----LMYACQRGDIV 137
            : ||.|  |.|.|.|||:.:....                  ..|| ||     |..||:.||:.
Zfish    57 EIPAALLSTSSSSSSSSSTSSSTTGGGSSAGSTPDSGSASPGGSGCGTSGAFRELFEACRNGDVS 121

  Fly   138 QVLAQMREKPELLRQRDRSHRNA--LHYCAAQDSEGSKDLVAAASIAIAAPELLESA------DE 194
            :|...:....  :..:|.:.|.:  ||:.|   ..|.||:|         ..||::.      |:
Zfish   122 RVKRLVDSVN--VNAKDMAGRKSTPLHFAA---GFGRKDVV---------EHLLQTGANVHARDD 172

  Fly   195 DGFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPD 259
            .|..|||.|...|:..:|:|||...||.||.||..::.:|.|.:.|:::....:|..||.....:
Zfish   173 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRN 237

  Fly   260 ANGGTPLHYA-----AQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQ-- 317
            .:|.:.|..|     |.:.|..|:|...:|:.|.:....:.:|..|      :|:....|||:
Zfish   238 TDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPL------NVNCHASDGRKST 296

  Fly   318 -------PLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLI--GLC-- 371
                   ||..||.....:.|..|::.||.|.:.||.||..||.|.|.||.|..:.|:  |.|
Zfish   297 SQKMLSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN 361

  Fly   372 ----------------------------GAPTDLIDSNGCTALHYAVT-----------LGH--- 394
                                        ||...|::.:|.:|:..|.|           .||
Zfish   362 AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELKERLTYEFKGHSLL 426

  Fly   395 -----ADAT--ARLLDLEADPNRQDRKGRTPAHCGC---SKGQFETLKLLKERGANLWLRNAKGD 449
                 ||.|  .:.|.||....:..:...|..||..   ...:.:..:||..:|||:..:|....
Zfish   427 QAAREADMTKVKKTLALEIINFKHPQTHETALHCAVVSPHPKRKQVTELLLRKGANVNEKNKDFM 491

  Fly   450 LPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRN 514
            .|||.||.....::|| :|.:...::|.....|::.||.||...:...|:|||.||||.
Zfish   492 TPLHVAAERAHNDILE-VLQKHGAKMNAVDTLGQTALHRAALAGHLQTCRLLLSYGADP------ 549

  Fly   515 SRGLVLTPLDG--ALQRGHRSTAKFLQAN---GGQPANKVRLSSRRTGNPFHETNATDMVRPLKY 574
                .:..|.|  |.|.|:.:..:.|..|   .....:...|.:.:.|:       .|.|:.|..
Zfish   550 ----AIVSLQGFTAAQMGNEAVQQILNENIPVRNSDVDYRLLEAAKAGD-------LDTVKQLCS 603

  Fly   575 VEKEELHDLRSSKK-------------YVVYLKRSDSD--NGNENGKADVGDGDCSCSEQTYR-K 623
            .:.....||.....             .|.||....:|  ..::.|...:.:   :||...|. .
Zfish   604 PQNVNCRDLEGRHSTPLHFAAGYNRVAVVEYLLHHGADVHAKDKGGLVPLHN---ACSYGHYEVA 665

  Fly   624 EQRLRH-----VCRRHKRRQLRRRTSSCGESKHERCSEICRSKSNIEIRRRKSRERYASSSEWEE 683
            |..:||     |....|...|.   .:..:.|:|.|..:.:..::...:.|..........|.:.
Zfish   666 ELLVRHGASVNVADLWKFTPLH---EAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDMVKEGDT 727

  Fly   684 ESAE---------DSCENCCYHKRQKDRVVNRKRSTSSRKSKNRDSSDPDEKNHSENHSSPEKGS 739
            :..:         |:.:..|..:.||           ....:|.:..|...:|.:..|.:....:
Zfish   728 DIQDLLRGDAALLDAAKKGCLARVQK-----------LCSLENINCRDTQGRNSTPLHLAAGYNN 781

  Fly   740 RKPLAVNGDHQAD-NGKDQTSTKERPPSASRHQTPPTKEGTFIKSPTQSAKSEKSGQMDNLLVEE 803
            .:......:|.|| |.:|                    :|..|  |..:|.|.....:..||::.
Zfish   782 LEVAEYLLEHGADVNAQD--------------------KGGLI--PLHNAASYGHVDIAALLIKY 824

  Fly   804 SHAVELTDE-----EQEAAKSVVTQVD---VHHDAEEIQTSKSSEEAPQAEENGKEKESEQEVKL 860
            :..|..||:     ..|||:...||:.   :.|.|:...               |.:|.:..:.|
Zfish   825 NTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM---------------KNQEGQTPLDL 874

  Fly   861 QLSEEETQLVSKEV----------EQVIIIAATALSSESKSS--SEEKSVEK------EL----- 902
            ..:::...|:...:          .|..:::|:.:|..|..|  |...|::.      ||
Zfish   875 ATADDIRALLIDAMPPEALPSCFKPQATVVSASVISPGSTPSCLSAASSIDNLAGPLTELAVSGA 939

  Fly   903 --PKEGQAPGENHDEEV 917
              |.:|....|..:.|:
Zfish   940 SGPADGATGTERKEGEI 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	32/106 (30%)
		ANK	193..335	CDD:238125	43/155 (28%)
		ANK repeat	195..226	CDD:293786	14/30 (47%)
		Ank_5	214..269	CDD:290568	17/54 (31%)
		ANK repeat	228..259	CDD:293786	6/30 (20%)
		ANK repeat	314..345	CDD:293786	12/39 (31%)
		Ank_2	319..412	CDD:289560	37/145 (26%)
		ANK	345..468	CDD:238125	45/178 (25%)
		ANK repeat	347..379	CDD:293786	15/63 (24%)
		ANK repeat	381..412	CDD:293786	12/51 (24%)
		ANK	409..538	CDD:238125	36/133 (27%)
		ANK repeat	414..479	CDD:293786	18/67 (27%)
		ANK repeat	419..445	CDD:293786	7/28 (25%)
		Ank_2	420..511	CDD:289560	30/93 (32%)
		ANK repeat	481..511	CDD:293786	13/29 (45%)
		Ank_2	486..>545	CDD:289560	19/63 (30%)
		ANK repeat	516..542	CDD:293786	7/30 (23%)
tnksa	XP_009293648.1	Ank_4	111..161	CDD:290365	15/63 (24%)
		ANK	133..247	CDD:238125	36/125 (29%)
		ANK repeat	143..171	CDD:293786	9/39 (23%)
		Ank_2	145..237	CDD:289560	32/103 (31%)
		ANK repeat	173..204	CDD:293786	14/30 (47%)
		ANK	201..387	CDD:238125	48/191 (25%)
		ANK repeat	206..237	CDD:293786	6/30 (20%)
		ANK repeat	303..331	CDD:293786	9/27 (33%)
		Ank_2	305..397	CDD:289560	25/91 (27%)
		ANK repeat	333..364	CDD:293786	12/30 (40%)
		ANK repeat	366..397	CDD:293786	3/30 (10%)
		ANK repeat	455..487	CDD:293786	8/31 (26%)
		Ank_2	458..552	CDD:289560	30/104 (29%)
		ANK	484..669	CDD:238125	46/205 (22%)
		ANK repeat	489..520	CDD:293786	9/31 (29%)
		ANK repeat	522..552	CDD:293786	13/39 (33%)
		Ank_2	527..646	CDD:289560	30/135 (22%)
		ANK	608..733	CDD:238125	21/130 (16%)
		ANK repeat	618..646	CDD:293786	4/27 (15%)
		Ank_2	620..712	CDD:289560	17/97 (18%)
		ANK repeat	648..679	CDD:293786	8/33 (24%)
		ANK repeat	681..712	CDD:293786	5/33 (15%)
		ANK repeat	734..764	CDD:293786	5/40 (13%)
		Ank_4	735..789	CDD:290365	8/64 (13%)
		ANK	761..885	CDD:238125	29/160 (18%)
		ANK repeat	768..799	CDD:293786	6/30 (20%)
		Ank_2	773..865	CDD:289560	23/128 (18%)
		ANK repeat	801..832	CDD:293786	8/32 (25%)
		ANK repeat	834..865	CDD:293786	7/45 (16%)
		SAM_tankyrase1,2	958..1021	CDD:188923
		SAM	962..1019	CDD:197735
		tankyrase_like	1023..1245	CDD:238718
		PARP	1037..1240	CDD:279038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910