DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and ANKRD16

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_001009941.1	Gene:	ANKRD16 / 54522	HGNCID:	23471	Length:	361	Species:	Homo sapiens

Alignment Length:	398	Identity:	105/398 - (26%)
Similarity:	163/398 - (40%)	Gaps:	54/398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 DPAQL--TVSQSQSSSTVARRRLAEGC-----TSLMYACQRGDIVQVLAQMREKPEL-LRQRDRS 156
            ||.:|  .|.:.:..:.....:.|.||     .:|::...|.....|||.:.|...: :...:|.
Human     6 DPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRD 70

  Fly   157 HRNALHYCAAQDSEGSKDLVAAASIAIAAPELLESADEDGFTPLHLAVIQGNLAMVNLLLANKAD 221
            ::..||..|   |.|.:|.|.......||.:.|:.||   :|||.:|..:.||.::..|:.:.|:
Human    71 YKRPLHEAA---SMGHRDCVRYLLGRGAAVDCLKKAD---WTPLMMACTRKNLGVIQELVEHGAN 129

  Fly   222 VNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPDAN-GGTPLHYAAQMCGASKQDSKQQAS 285
            ....:.:|.:..|.|:..|:...|:.:|.......|.::. ..||||.|| |.|
Human   130 PLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAA-MHG----------- 182

  Fly   286 SSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAK-AVIALVKAGARVESSDKDGL 349
                   .||.:.:||...|...|.:|..|...|:.|...|... |.:.|.:.||.:.:.|..|.
Human   183 -------HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240

  Fly   350 TALHCAGSRGHTECIDTLIGLCGAPTDL-IDSNGCTALHYAVTLGHADATARLLDLEADPNRQDR 413
            .|||.|...|..|.|..|:...|...|: ..|...||||||...||......||.|.||.|.:|.
Human   241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDE 305

  Fly   414 KGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTT 478
            |.|:..|..|:.......|.|.:.|    |::::              ::...|..|.|::.:..
Human   306 KNRSALHLACAGQHLACAKFLLQSG----LKDSE--------------DITGTLAQQLPRRADVL 352

  Fly   479 SNDGRSLL 486
            ...|.|.:
Human   353 QGSGHSAM 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	27/99 (27%)
		ANK	193..335	CDD:238125	36/143 (25%)
		ANK repeat	195..226	CDD:293786	8/30 (27%)
		Ank_5	214..269	CDD:290568	13/55 (24%)
		ANK repeat	228..259	CDD:293786	7/30 (23%)
		ANK repeat	314..345	CDD:293786	8/31 (26%)
		Ank_2	319..412	CDD:289560	34/94 (36%)
		ANK	345..468	CDD:238125	36/123 (29%)
		ANK repeat	347..379	CDD:293786	11/32 (34%)
		ANK repeat	381..412	CDD:293786	14/30 (47%)
		ANK	409..538	CDD:238125	15/78 (19%)
		ANK repeat	414..479	CDD:293786	11/64 (17%)
		ANK repeat	419..445	CDD:293786	6/25 (24%)
		Ank_2	420..511	CDD:289560	11/67 (16%)
		ANK repeat	481..511	CDD:293786	2/6 (33%)
		Ank_2	486..>545	CDD:289560	0/1 (0%)
		ANK repeat	516..542	CDD:293786
ANKRD16	NP_001009941.1	Ank_2	10..95	CDD:372319	19/87 (22%)
		ANK 1	36..66		6/29 (21%)
		ANK repeat	37..68	CDD:293786	6/30 (20%)
		ANK repeat	70..101	CDD:293786	9/33 (27%)
		ANK 2	70..99		9/31 (29%)
		PHA02875	75..>301	CDD:165206	76/250 (30%)
		ANK repeat	103..134	CDD:293786	10/33 (30%)
		ANK 3	103..132		10/31 (32%)
		ANK 4	136..165		6/28 (21%)
		ANK 5	170..200		13/48 (27%)
		ANK repeat	172..202	CDD:293786	14/48 (29%)
		Ank_2	175..304	CDD:372319	48/147 (33%)
		ANK repeat	204..236	CDD:293786	8/31 (26%)
		ANK 6	204..234		8/29 (28%)
		ANK repeat	238..269	CDD:293786	11/30 (37%)
		ANK 7	238..268		10/29 (34%)
		ANK repeat	272..304	CDD:293786	15/31 (48%)
		ANK 8	273..302		13/28 (46%)
		Ank_2	278..>340	CDD:372319	21/79 (27%)
		ANK 9	306..335		8/32 (25%)
		ANK repeat	306..330	CDD:293786	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000