DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and NFKB1

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_001369554.1	Gene:	NFKB1 / 4790	HGNCID:	7794	Length:	969	Species:	Homo sapiens

Alignment Length:	621	Identity:	136/621 - (21%)
Similarity:	214/621 - (34%)	Gaps:	177/621 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QQQQRQEAADKVIAMPGSSQDTDAAAEAAVDVPETDPDPAQLTVSQSQSSSTVA--RRRLAEGCT 125
            :.::..|..||     ...::|.......::..|.|.:|::.||...:.:.|.|  .:..:.|..
Human   439 ESKKDPEGCDK-----SDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQ 498

  Fly   126 SLMYACQRGDIVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLE 190
            ..::.              ||...|.:|   |.|||...|.   .|...::.|....:.|.:
Human   499 DNLFL--------------EKAMQLAKR---HANALFDYAV---TGDVKMLLAVQRHLTAVQ--- 540

  Fly   191 SADEDGFTPLHLAVIQGNLAMVNLLLANKA-----DVNAVDNEGHSV-VHWATVCGEVESLRAVL 249
              ||:|.:.||||:|..:..:|..||...:     |:..:.|:.:.. :|.|.:..:.:.:..:|
Human   541 --DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLL 603

  Fly   250 AAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSS--VDVQD 312
            .|||.::..|..|.:.||.||:. |..|                  :|.|||.|.:::  :|..:
Human   604 RAGADLSLLDRLGNSVLHLAAKE-GHDK------------------VLSILLKHKKAALLLDHPN 649

  Fly   313 KDGRQPLLWAASAGSAKAVIALVKAGARVESSD-KDGLTALHCAGSRGHTECIDTLIGLCGAPTD 376
            .||...:..|..:.|...::.||.|||.|.:.: |.|.||||.|                 ...|
Human   650 GDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLA-----------------VEHD 697

  Fly   377 LIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANL 441
            .|...||..|...   .|.|:|.             ..|.||.|....:|......|||..||:.
Human   698 NISLAGCLLLEGD---AHVDSTT-------------YDGTTPLHIAAGRGSTRLAALLKAAGADP 746

  Fly   442 WLRNAKGDLPLH------------EAAASGRREL---LEW----LLAQRPKQVNTTSNDGRSLLH 487
            .:.|.:   ||:            |....|...|   ..|    :|..:|.:...||:|
Human   747 LVENFE---PLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDD------ 802

  Fly   488 IAAANDYTDMC--------KLL---------------LDYGADVNAV-------------YRNSR 516
            :.|..|...:.        |||               |..|...||.             |..|.
Human   803 LLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSG 867

  Fly   517 GLVLTPLDGALQRGHRSTAKFLQANGG-----QPANKVRLSSRRTGNPFHETNATDMV------- 569
            |.|...::...|.|:....:.:||...     ..|:.:.||...|.....|...:|.|
Human   868 GTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVET 932

  Fly   570 --RPLKYVEKEELHDLRSSKKYVVYLKRSDSDNGNE 603
              |.|.:.|.      .:|...::.|.:...|.|.|
Human   933 SFRKLSFTES------LTSGASLLTLNKMPHDYGQE 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	24/103 (23%)
		ANK	193..335	CDD:238125	37/149 (25%)
		ANK repeat	195..226	CDD:293786	10/35 (29%)
		Ank_5	214..269	CDD:290568	14/60 (23%)
		ANK repeat	228..259	CDD:293786	6/31 (19%)
		ANK repeat	314..345	CDD:293786	10/30 (33%)
		Ank_2	319..412	CDD:289560	23/93 (25%)
		ANK	345..468	CDD:238125	32/142 (23%)
		ANK repeat	347..379	CDD:293786	7/31 (23%)
		ANK repeat	381..412	CDD:293786	6/30 (20%)
		ANK	409..538	CDD:238125	37/183 (20%)
		ANK repeat	414..479	CDD:293786	19/83 (23%)
		ANK repeat	419..445	CDD:293786	7/25 (28%)
		Ank_2	420..511	CDD:289560	27/132 (20%)
		ANK repeat	481..511	CDD:293786	9/52 (17%)
		Ank_2	486..>545	CDD:289560	17/99 (17%)
		ANK repeat	516..542	CDD:293786	6/25 (24%)
NFKB1	NP_001369554.1	ANK repeat	685..717	CDD:293786	13/51 (25%)
		Ank_2	690..>733	CDD:423045	16/75 (21%)
		Death_NFkB1_p105	816..891	CDD:260063	13/74 (18%)
		RHD-n_NFkB1	43..244	CDD:143651
		IPT_NFkappaB	251..352	CDD:238582
		Nuclear localization signal. /evidence=ECO:0000255	361..366
		GRR	373..395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..454		3/19 (16%)
		Interaction with CFLAR. /evidence=ECO:0000269\|PubMed:13679070	436..969		136/621 (22%)
		ANKYR	500..706	CDD:223738	66/266 (25%)
		ANK repeat	543..580	CDD:293786	10/36 (28%)
		ANK repeat	582..613	CDD:293786	6/30 (20%)
		Ank_2	587..681	CDD:403870	30/112 (27%)
		Essential for interaction with HIF1AN. /evidence=ECO:0000269\|PubMed:17003112	651..685		10/33 (30%)
		ANK repeat	651..681	CDD:293786	10/29 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000