DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and Tnni3k

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_796040.3	Gene:	Tnni3k / 435766	MGIID:	2443276	Length:	834	Species:	Mus musculus

Alignment Length:	528	Identity:	129/528 - (24%)
Similarity:	195/528 - (36%)	Gaps:	114/528 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 LRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLESADEDGFTPLHLAVIQGNLAMVNL 214
            |..|.....:.||.|.|  ..|:|..:.|..:....|..|   ..:||..|||||.:.:|.::..
Mouse    60 LNYRTERGLSLLHLCCA--CGGNKSHIRALMLKGLRPSRL---TRNGFPALHLAVYKDSLELITS 119

  Fly   215 LLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPDANGGTPLHYAAQMCGASKQD 279
            ||.:.|||......|.:.:|.|.:.|..|::..:|..||:|...||...||||.||..
Mouse   120 LLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYY------- 177

  Fly   280 SKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESS 344
                                                          |..:....|:|.||.|..|
Mouse   178 ----------------------------------------------GHEQVTSVLLKFGADVNVS 196

  Fly   345 DKDGLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSNGCTALHYAVTLGHADATARLL--DLEAD 407
            .:.|...||.|.::|....:..|:....|..:..|:.....||:....||.:..:.||  |||..
Mouse   197 GEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQSDLEVQ 261

  Fly   408 PNRQDRKGRTPAHCGCSKGQFETLK-LLKERGA-NLWLRNAKGDLPLHEAAASGRR-ELLEWLLA 469
            |:..:..|.||.|..|..|.||..| ::...|. :|...|...:...|.|...|:. :|:::||.
Mouse   262 PHVINIYGDTPLHLACYNGNFEVAKEIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLD 326

  Fly   470 QRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVY---RNSRGL--VLTPLDGALQR 529
            |....:|....||.:.||.|..:.:..:.:.|||.|||:|.|.   ..|.|.  ..|.|..|.::
Mouse   327 QNAVNINHRGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEK 391

  Fly   530 GHRSTAKFLQANGGQPANKVRLSSRRTGNPFHETNATDMVRPL---KYVEKE------------- 578
            ||.:....|: :..:|.::  |.......|..:.:...:..||   |.:.||
Mouse   392 GHDAIVTLLK-HYKRPQDE--LPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPS 453

  Fly   579 ---------ELHDLRSSKKY-----------VVYLKRSDSDNGNENGKADVGDGDCSCSEQTYRK 623
                     |.|::..|..:           :|.:||.     ..|......|.|..|.|.:...
Mouse   454 RFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRY-----RANTYCSKSDVDMFCREVSILC 513

  Fly   624 EQRLRHVC 631
            :  |.|.|
Mouse   514 Q--LNHPC 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	24/75 (32%)
		ANK	193..335	CDD:238125	31/141 (22%)
		ANK repeat	195..226	CDD:293786	13/30 (43%)
		Ank_5	214..269	CDD:290568	20/54 (37%)
		ANK repeat	228..259	CDD:293786	9/30 (30%)
		ANK repeat	314..345	CDD:293786	6/30 (20%)
		Ank_2	319..412	CDD:289560	25/94 (27%)
		ANK	345..468	CDD:238125	34/127 (27%)
		ANK repeat	347..379	CDD:293786	7/31 (23%)
		ANK repeat	381..412	CDD:293786	10/32 (31%)
		ANK	409..538	CDD:238125	40/136 (29%)
		ANK repeat	414..479	CDD:293786	20/67 (30%)
		ANK repeat	419..445	CDD:293786	8/27 (30%)
		Ank_2	420..511	CDD:289560	29/93 (31%)
		ANK repeat	481..511	CDD:293786	12/29 (41%)
		Ank_2	486..>545	CDD:289560	19/63 (30%)
		ANK repeat	516..542	CDD:293786	7/27 (26%)
Tnni3k	NP_796040.3	ANK repeat	66..98	CDD:293786	9/36 (25%)
		ANK 1	66..96		8/31 (26%)
		Ank_2	71..164	CDD:289560	31/97 (32%)
		ANK	99..220	CDD:238125	42/173 (24%)
		ANK repeat	100..131	CDD:293786	13/30 (43%)
		ANK 2	100..129		13/28 (46%)
		ANK 3	133..162		9/28 (32%)
		ANK repeat	134..164	CDD:293786	9/29 (31%)
		Ank_2	138..231	CDD:289560	30/145 (21%)
		ANK	161..289	CDD:238125	42/180 (23%)
		ANK repeat	166..197	CDD:293786	12/83 (14%)
		ANK 4	166..195		12/81 (15%)
		ANK repeat	199..231	CDD:293786	7/31 (23%)
		ANK 5	199..229		7/29 (24%)
		ANK	228..359	CDD:238125	36/130 (28%)
		ANK 6	233..262		9/28 (32%)
		Ank_4	237..286	CDD:290365	18/48 (38%)
		ANK repeat	268..301	CDD:293786	11/32 (34%)
		ANK 7	268..297		10/28 (36%)
		Ank_2	273..368	CDD:289560	29/94 (31%)
		ANK repeat	303..336	CDD:293786	8/32 (25%)
		ANK 8	303..334		7/30 (23%)
		ANK	333..>400	CDD:238125	21/66 (32%)
		ANK repeat	338..368	CDD:293786	12/29 (41%)
		ANK 9	338..367		11/28 (39%)
		Ank_4	339..400	CDD:290365	19/60 (32%)
		ANK 10	380..409		7/29 (24%)
		TyrKc	462..718	CDD:197581	14/65 (22%)
		PKc_TNNI3K	468..721	CDD:270966	12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910