DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and nfkb2

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_001001840.2	Gene:	nfkb2 / 415100	ZFINID:	ZDB-GENE-030131-6701	Length:	902	Species:	Danio rerio

Alignment Length:	588	Identity:	134/588 - (22%)
Similarity:	209/588 - (35%)	Gaps:	155/588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GSSQDTDAAAEAAVDVPETDPDPAQLTVSQSQSSSTVARRRLAE----GCTSLMYACQRGDIVQV 139
            |.:|.:|:.       |:||.     ..:||||:|.: |::|.:    ...:|...|....::|.
Zfish   414 GGAQMSDSP-------PQTDG-----ANTQSQSNSQI-RQQLIQIALHNRANLAAKCNARALLQY 465

  Fly   140 LAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAA--SIAIAAPEL---LESADEDGF-- 197
            .:....:|.|..||        |.|..||..|...|..|.  ...:.|.:|   |.|:.:..|
Zfish   466 SSTGDARPLLALQR--------HLCGVQDENGDTPLHLAIIHQKTVVAEQLIKALNSSPQQKFFN 522

  Fly   198 -------TPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASV 255
                   .|||||||.....:|.:|:.:.||.:.:|.||.:|:|.|...|:...||.||:
Zfish   523 KLNKLSQAPLHLAVITKQPKLVEMLMKSGADPSLLDREGRTVLHLAAHTGDDVILRLVLS----- 582

  Fly   256 AKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLL 320
                                                    :||   .|....::..|..|:.|:.
Zfish   583 ----------------------------------------LLG---EHHSHLINSADFTGQYPVH 604

  Fly   321 WAASAGSAKAVIALVKAGARVESSD-KDGLTALHCAGSRGHTECIDTLIGL-CGAPTDL-IDSNG 382
            .|......:.:..||:|||::...: |.|.||||.|       ..|.|:.| |...|:| .|.|.
Zfish   605 LAVKKDGERCLRLLVEAGAKINMPEQKSGCTALHLA-------VRDNLLKLACNLITELKADVNA 662

  Fly   383 CT-----ALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKG---------------- 426
            ||     .||.|.:.|.....:.|:...||...::.:   |.....|..
Zfish   663 CTYGGNSPLHLAASQGSPHLCSMLIAAGADKRIENDE---PLFLSSSSSDEDEESEKKLSEDMVQ 724

  Fly   427 QFETLKLLKERGA-NLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAA 490
            |...|.:..|||. |...|.|.|..|...|.:...|:||:.....:|..::..    |:.:....
Zfish   725 QVHCLSISSERGVFNPRKRPAAGHTPFDLAKSQKVRDLLDGRKGPKPNSLSPK----RTKISTEE 785

  Fly   491 ANDYTDMCKLLLDYGADVNAVYRNSRGLVL---TPLDGALQRGHRSTAKFLQANGGQPANKVRLS 552
            .|...|            |.|.....|:::   .|.....::....|...|..:...|..|:..|
Zfish   786 VNQDLD------------NEVLSKLCGILIHDDVPWRELAEKLGMLTLTHLYQDSASPCQKLLES 838

  Fly   553 SRRTGNPFHETNATDMVRPLKYV-EKEELHDLRSSKKYVVYLKRSDSDNGNENGKADVGDGDCSC 616
            .:.:|.|     ...:|..|:.: .:|.:..||.|:      .|.|..:.:..  .|.|.|..|.
Zfish   839 YQLSGGP-----VDGLVEALQALGVREGVRLLRDSQ------PREDKQSSDST--EDSGFGSQSI 890

  Fly   617 SEQ 619
            .|:
Zfish   891 GEE 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	30/112 (27%)
		ANK	193..335	CDD:238125	30/150 (20%)
		ANK repeat	195..226	CDD:293786	12/39 (31%)
		Ank_5	214..269	CDD:290568	14/54 (26%)
		ANK repeat	228..259	CDD:293786	10/30 (33%)
		ANK repeat	314..345	CDD:293786	8/30 (27%)
		Ank_2	319..412	CDD:289560	30/100 (30%)
		ANK	345..468	CDD:238125	40/147 (27%)
		ANK repeat	347..379	CDD:293786	12/33 (36%)
		ANK repeat	381..412	CDD:293786	10/35 (29%)
		ANK	409..538	CDD:238125	25/148 (17%)
		ANK repeat	414..479	CDD:293786	17/81 (21%)
		ANK repeat	419..445	CDD:293786	7/42 (17%)
		Ank_2	420..511	CDD:289560	20/107 (19%)
		ANK repeat	481..511	CDD:293786	4/29 (14%)
		Ank_2	486..>545	CDD:289560	8/61 (13%)
		ANK repeat	516..542	CDD:293786	4/28 (14%)
nfkb2	NP_001001840.2	RHD-n_NFkB2	53..238	CDD:143650
		RHD_dimer	246..344	CDD:292797
		Ank_2	<483..558	CDD:289560	21/74 (28%)
		ANK	485..619	CDD:238125	39/181 (22%)
		ANK repeat	488..525	CDD:293786	8/36 (22%)
		ANK repeat	528..558	CDD:293786	11/29 (38%)
		Ank_2	532..627	CDD:289560	33/142 (23%)
		ANK	558..687	CDD:238125	44/183 (24%)
		ANK repeat	560..596	CDD:293786	13/83 (16%)
		ANK repeat	599..629	CDD:293786	8/29 (28%)
		Ank_2	604..697	CDD:289560	30/99 (30%)
		ANK repeat	632..664	CDD:293786	14/38 (37%)
		ANK repeat	666..697	CDD:293786	7/30 (23%)
		Death_NFkB2_p100	794..867	CDD:176776	14/77 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000