DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and Rel

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	150/759 - (19%)
Similarity:	245/759 - (32%)	Gaps:	259/759 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DNDHPPQQEKQEQQQQQQQRQEAADKVIAMPGSSQDTDAAAEAAVDVPETDPD--------PA-- 102
            |..|.||....||..::.:.:..::    |.|:....:.|....  .|:|.|:        ||
  Fly   145 DIKHVPQLRIVEQPVEKFRFRYKSE----MHGTHGSLNGANSKR--TPKTFPEVTLCNYDGPAVI 203

  Fly   103 -----QLTVSQSQSSSTVARRRLAEGCT--SLMYACQRGDIVQ-------------VLAQMREKP 147
                 |..:....|...|.|:...:.|.  .|..:.:||.:.|             :..::.:|.
  Fly   204 RCSLFQTNLDSPHSHQLVVRKDDRDVCDPHDLHVSKERGYVAQFINMGIIHTAKKYIFEELCKKK 268

  Fly   148 E-----LLRQRDRSHR--NALHYCAAQDSEGSKDLVAAASIAIAAPELLESADEDGFTPLHLAVI 205
            :     .:.:|:.||:  ..||    |::|.....:....:.:.. |..:..|...:.||...|.
  Fly   269 QDRLVFQMNRRELSHKQLQELH----QETEREAKDMNLNQVRLCF-EAFKIEDNGAWVPLAPPVY 328

  Fly   206 Q-----------GNLAMVNL--------------LLANKADVNAV-------DNEGHSV------ 232
            .           |.|.:|.|              ||..|.....:       |.:|.:|
  Fly   329 SNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRFFEEDEDGETVWEAYAK 393

  Fly   233 -----VH--WATVCGE---------------VESLRAVLAAGASVAKPDANG--GTPLHY----- 268
                 ||  :|.||..               :|.:|         ...|...  ..|..|
  Fly   394 FRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIR---------PSDDERSFPALPFRYKPRSV 449

  Fly   269 ----AAQMCGASKQDSKQQASSSNSSRLSLEILGI---------LLSHPQSSVDVQDKDGRQPLL 320
                ..:..|:|...|.....|||:|....:.||:         |..|.|:   :.::.||:..|
  Fly   450 IVSRKRRRTGSSANSSSSGTESSNNSLDLPKTLGLAQPPNGLPNLSQHDQT---ISEEFGREKHL 511

  Fly   321 --WAASAGSAKAVIALVKAGARVESSD-------------KDGLTALHCAGSRGHT-ECIDTLIG 369
              :.||....|.:        ...|||             .||.........|..| :|:|.|..
  Fly   512 NEFIASEDFRKLI--------EHNSSDLEKICQLDMGELQHDGHNRAEVPSHRNRTIKCLDDLFE 568

  Fly   370 LCG----APTD--------------LIDSNGCTALHYAVT-----LGHADATARLLD-------- 403
            :..    :|..              |.:.|..|.||..::     |..|..|.::::
  Fly   569 IYKQDRISPIKISHHKVEKWFIEHALNNYNRDTLLHEVISHKKDKLKLAIQTIQVMNYFNLKDVV 633

  Fly   404 ---LEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLE 465
               |.||       |.:..|..|.:.:...::.|...|.|..|:|..|:.|||.|........:|
  Fly   634 NSTLNAD-------GDSALHVACQQDRAHYIRPLLGMGCNPNLKNNAGNTPLHVAVKEEHLSCVE 691

  Fly   466 WLLAQRPK---QVNTTSNDGRSLLHIAAANDYTDMCKLLLDYG---------ADVN-----AVYR 513
            ..|...|.   .::.|::||.:.||:|...:..|:.|.|:.|.         .|.|     ||..
  Fly   692 SFLNGVPTVQLDLSLTNDDGLTPLHMAIRQNKYDVAKKLISYDRTSISVANTMDGNNALHMAVLE 756

  Fly   514 NSRGLVLTPLDGALQRGHRSTAKFLQANGGQPANKVRLSSRRTGNPFHETNATD-MVRPLK--YV 575
            .|..|::..||..    :.:....|||........:.|:.|:         |.| :|:.||  |.
  Fly   757 QSVELLVLILDAQ----NENLTDILQAQNAAGHTPLELAERK---------ANDRVVQLLKNVYP 808

  Fly   576 EKEEL----------HDLRSSKKYVVYLKRSDSDNGNENGKADV 609
            ||.||          .::.||           ||..::.|:.::
  Fly   809 EKGELAMTWIPCKVKEEIDSS-----------SDESSDAGQLEI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	24/150 (16%)
		ANK	193..335	CDD:238125	42/223 (19%)
		ANK repeat	195..226	CDD:293786	10/62 (16%)
		Ank_5	214..269	CDD:290568	17/114 (15%)
		ANK repeat	228..259	CDD:293786	9/58 (16%)
		ANK repeat	314..345	CDD:293786	7/32 (22%)
		Ank_2	319..412	CDD:289560	26/142 (18%)
		ANK	345..468	CDD:238125	34/170 (20%)
		ANK repeat	347..379	CDD:293786	9/50 (18%)
		ANK repeat	381..412	CDD:293786	10/46 (22%)
		ANK	409..538	CDD:238125	34/145 (23%)
		ANK repeat	414..479	CDD:293786	16/67 (24%)
		ANK repeat	419..445	CDD:293786	6/25 (24%)
		Ank_2	420..511	CDD:289560	27/107 (25%)
		ANK repeat	481..511	CDD:293786	11/43 (26%)
		Ank_2	486..>545	CDD:289560	18/72 (25%)
		ANK repeat	516..542	CDD:293786	6/25 (24%)
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	34/196 (17%)
		IPT_NFkappaB	343..446	CDD:238582	19/111 (17%)
		ANK	638..766	CDD:238125	34/134 (25%)
		ANK repeat	640..671	CDD:293786	8/37 (22%)
		Ank_4	641..691	CDD:290365	13/49 (27%)
		ANK repeat	673..708	CDD:293786	8/34 (24%)
		Ank_2	678..775	CDD:289560	24/100 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
	1	1.000