Protein Alignment CG42534 and Ankrd35

DIOPT Version :10

• Sequence 1: NP_651560.2
• Gene: CG42534 / 43298
• FlyBaseID: FBgn0260487
• Length: 1555
• Species: Drosophila melanogaster
• Sequence 2: NP_001420139.1
• Gene: Ankrd35 / 365881
• RGDID: 1305527
• Length: 990
• Species: Rattus norvegicus
• Alignment Length: 1069
• Identity: 224/1069 - (20%)
• Similarity: 351/1069 - (32%)
• Gaps: 351/1069 - (32%)

  Fly   109 SQSSSTVARRRLAEGCTSLMYACQRGDIVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSK 173
            |.|||.||..:.......|:.|.||||:.:|
  Rat     6 SCSSSQVAVEKWNRRDQKLLEAVQRGDVGRV---------------------------------- 36

  Fly   174 DLVAAASIAIAAPELLESADEDGFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATV 238
              .|.||...|.|..|   |.:|.:|.|||..:|....:.:||||.||:|:.:.:|.:.:|.||:
  Rat    37 --AALASRKSARPTKL---DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATI 96

  Fly   239 CGEVESLRAVLAAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSH 303
            ..:.:.::.:|..||:....||...:|||:|              |||..:|.:      :||..
  Rat    97 SCQPQCVKVLLQHGANEDAVDAENRSPLHWA--------------ASSGCASSV------LLLCD 141

  Fly   304 PQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLI 368
            .::.:||.|.|||.||:.|:..|.|.....|::.||||..:|||..:||..|..:|..|..:.|:
  Rat   142 HEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEKGSAEVAELLL 206

  Fly   369 GLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRT----PAHCGCS----- 424
            . .||....:||.|..|||||  ||..|.....| |:...||:.|.||.    |.|...:
  Rat   207 S-HGADAGAVDSLGHNALHYA--LGTQDRELWRL-LQQALNRRRRGGRELVQHPDHASQASSSES 267

  Fly   425 -------------KGQFETLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVN 476
                         ||:        |||:..|                      .|...:..::|:
  Rat   268 PWRAEPEEEQEEEKGE--------ERGSEEW----------------------RWKFEEEQRKVH 302

  Fly   477 TTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRSTAKFLQAN 541
            ....:   ||      ..||.||               :|......|:..::...:.....|...
  Rat   303 QLEQE---LL------QKTDECK---------------ARAAAFVSLENQIREQVQELGYLLVQV 343

  Fly   542 GGQPAN-----KVRLSSRRTGNPFH-----------ETNATDMVRPLKYVEKEELHDLRSSKKYV 590
            .|.|.|     :........|.|.:           :..||..:.|....::.|  ||..::.:.
  Rat   344 PGAPRNQGPGLRPEGDGMEQGCPLNLLAEWIQELKKQQKATATINPTLVPKRAE--DLAPAETHY 406

  Fly   591 VYLKRSDSDNGNENGKADVGDGDCSCSEQTYRKEQRL-----RHVCRRHKRRQLRRRTS---SCG 647
            ....:...:.|..........|..:..:.....||.|     ..||...|.|.|...|.   :.|
  Rat   407 EVPGKFQPEQGLSQSPRSETIGKATGQQLNTNGEQNLDLDNTEQVCADQKERALAPGTEPAVTVG 471

  Fly   648 E------------SKHERCSEICRSKSNIEIRRRKSR----------ERYASSSEWEEESAEDSC 690
            |            ...|..:.:.|.|.  ..|...||          ...|:::.||:..|
  Rat   472 EPVGIAAMNQLLLQLREELAAVWREKD--AARGALSRPVLEGALGTPRAEAAAAAWEKMEA---- 530

  Fly   691 ENCCYHKRQKDRVVNR----------KRSTSSRKSKNRDSSDPDEK---NHSENHSSPEKGSR-K 741
                    :.::|:.|          |....::.|  ||.:....:   ...|...:|  |:| :
  Rat   531 --------RLEKVLVRLDGAKMGLHVKPEVPAQGS--RDGAPKIVQGCTKEQEGKRAP--GARGE 583

  Fly   742 PLAVNGDHQADNGKDQTSTKERPPSASR------------------------HQTPPTKEGTFIK 782
            ||...|..||..|.......|:..||.|                        .......:..|:.
  Rat   584 PLGAPGGEQALGGGLAKGQLEKEVSALRLSNSNLLEELEELGRERQRLQGELQSLTQKLQREFVP 648

  Fly   783 SPTQSAKSEKSGQMDNLLVEE----------------------------------------SHAV 807
            .|....:.::..:...||.||                                        |.|.
  Rat   649 KPEAQVQLQQLRRSVGLLTEELAIEKEATEKLRRRLASQTSGLQGLWNCFPPDLVGKGSARSTAA 713

  Fly   808 ELTDEEQEAAKSVVTQVDVHHDAEEIQTSKSSEE---------------------APQA----EE 847
            |..:|.|..   :.|.||.|.:::::|.....|.                     :||.    |:
  Rat   714 EPLEELQAC---ISTLVDRHLESQQVQARLEEENQRLRGSLPPCGEPEASLKATASPQVAALEED 775

  Fly   848 NGKEKESEQEVKLQLSEEE------TQLVSKEVEQVIIIAATALSSESKSSSEEKSVEKELPKEG 906
            .||.:|..:.|:..:|.:.      .||:.:..|:|    |...:.|:.|..:.:.....|..:.
  Rat   776 LGKLEEELRAVQATMSGKSQEICKLKQLLYQATEEV----AELRAREAASLRQHEKTRGSLVAQA 836

  Fly   907 QAPGENHDEEVK---EHQNPPTPYAPPAQPSTPPPPPKEEAAKPPSAAEQPQPNANTVEGMESAA 968
            ||.|    :|:|   |..|...               :|......:|||:.:.:    |.:.:.|
  Rat   837 QAWG----QELKVMLEKYNTAC---------------REMTRLRDTAAEERRRS----EELAARA 878

  Fly   969 AE----PASVGKKTEQMELAEAKPKPNTN 993
            ||    ...:..::||.|......|..||
  Rat   879 AEQERQAGEMRGRSEQFEKTAELLKEKTN 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:463710	27/98 (28%)
		ANK repeat	195..226	CDD:293786	13/30 (43%)
		ANKYR	209..514	CDD:440430	87/326 (27%)
		ANK repeat	228..259	CDD:293786	7/30 (23%)
		ANK repeat	314..345	CDD:293786	13/30 (43%)
		ANK repeat	347..379	CDD:293786	9/31 (29%)
		ANK repeat	381..412	CDD:293786	13/30 (43%)
		ANK repeat	414..479	CDD:293786	12/86 (14%)
		ANK repeat	419..445	CDD:293786	7/43 (16%)
		ANK repeat	481..511	CDD:293786	6/29 (21%)
		Ank_2	486..572	CDD:463710	15/101 (15%)
		ANK repeat	516..542	CDD:293786	3/25 (12%)
Ankrd35	NP_001420139.1	ANKYR	24..242	CDD:440430	86/280 (31%)
		ANK repeat	24..51	CDD:293786	13/65 (20%)
		ANK repeat	53..84	CDD:293786	13/30 (43%)
		ANK repeat	86..117	CDD:293786	7/30 (23%)
		ANK repeat	119..150	CDD:293786	12/50 (24%)
		ANK repeat	152..183	CDD:293786	13/30 (43%)
		ANK repeat	185..216	CDD:293786	9/31 (29%)
		Smc	<651..>965	CDD:440809	52/287 (18%)