DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and mib1

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_009295119.1	Gene:	mib1 / 352910	ZFINID:	ZDB-GENE-030404-2	Length:	1041	Species:	Danio rerio

Alignment Length:	691	Identity:	152/691 - (21%)
Similarity:	242/691 - (35%)	Gaps:	195/691 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QQRQEAADKVIAMPGSSQDTDAAAEAAVDVPE----TDPDPAQLTVSQSQSSSTVARRRLAEGCT 125
            ||....:|..:.:.|:|...:.||...| .|.    |:...|.||.|.|     |...||::...
Zfish   373 QQIYSDSDLKVEVCGTSWTYNPAAVTKV-APAGSAVTNASGAVLTESPS-----VPAERLSQLLK 431

  Fly   126 SLMYACQRGDIVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLE 190
            .|....:.|||.:.|.:.....:|.:..|                                 :|:
Zfish   432 KLFETQESGDINEELVKAAANGDLAKVED---------------------------------ILK 463

  Fly   191 SADED------GFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVL 249
            ..|.|      |.|.:..|...|::.::.|||.:..|:.|.|.:|...||.|:...|...:..:.
Zfish   464 RPDVDVNGQCAGHTAMQAASQNGHVDVLKLLLKHSVDLEAEDKDGDRAVHHASFGDEGSVIEVLH 528

  Fly   250 AAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLS---HPQSSVDVQ 311
            ..||.:...:....||||.|.                   ::..|:::..||.   ||    .:|
Zfish   529 RGGADLNARNKRRQTPLHIAV-------------------NKGHLQVVKTLLDFGCHP----SLQ 570

  Fly   312 DKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAP-- 374
            |.:|..||..|.|......:..|::|||.|..::.:|..|||.|..||:...:..|:.....|
Zfish   571 DSEGDTPLHDAISKKRDDMLSVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWI 635

  Fly   375 TDLIDSNGCTALHYAVTLGHADATARLLDLEADPNR--QDRKGRTPAHCGCSKGQFETLKLLKER 437
            .|....:|.||||.|....|.: .|.||..:.:.|.  |:...:|..|....:...:.::||...
Zfish   636 VDEKKDDGYTALHLAALNNHVE-VAELLVHQGNANLDVQNVNQQTALHLAVERQHTQIVRLLVRA 699

  Fly   438 GANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLL 502
            .|.|.:::..||.|||||...                        .:|..:....|..|:.|:
Zfish   700 EAKLDVQDKDGDTPLHEALRH------------------------HTLSQLRQLQDMQDVSKV-- 738

  Fly   503 DYGADVNAVYRNSRGLVLTPL--DGALQRGHRSTAKFLQANGGQPANKVRLSSRRTGNPFHETNA 565
                   ..:..|:..::..|  .||.::...|.|.||.|||..    :.:.:::..:|......
Zfish   739 -------EPWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGAD----LTIRNKKGQSPLDLCPD 792

  Fly   566 TDMVRPLKYVEKEELHDLRSSKKYVVYLKRSDSDNGN----------ENGKADVGDGDC----SC 616
            ..:.:.|....||:......|        ||.|.|.|          .:.|.|...|.|    :|
Zfish   793 PSLCKALAKCHKEKTSGQVGS--------RSPSLNSNNETLEECMVCSDMKRDTLFGPCGHIATC 849

  Fly   617 SEQTYRKEQRLRHVCRRHKRRQLRRRTS-----SCGESK----HERCSEICRSKSNIEIRRRKSR 672
            |..:.|.::.|  :|    :.|::.||.     .|.:.|    .:.|..:|
Zfish   850 SLCSPRVKKCL--IC----KEQVQSRTKIEECVVCSDKKAAVLFQPCGHMC-------------- 894

  Fly   673 ERYASSSEWEEESAEDSCENC------CYHKRQKDRVVNRK 707
                            :||||      |...|   .||.|:
Zfish   895 ----------------ACENCASLMKKCVQCR---AVVERR 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	19/104 (18%)
		ANK	193..335	CDD:238125	36/150 (24%)
		ANK repeat	195..226	CDD:293786	10/36 (28%)
		Ank_5	214..269	CDD:290568	17/54 (31%)
		ANK repeat	228..259	CDD:293786	7/30 (23%)
		ANK repeat	314..345	CDD:293786	10/30 (33%)
		Ank_2	319..412	CDD:289560	29/96 (30%)
		ANK	345..468	CDD:238125	35/126 (28%)
		ANK repeat	347..379	CDD:293786	10/33 (30%)
		ANK repeat	381..412	CDD:293786	11/32 (34%)
		ANK	409..538	CDD:238125	25/132 (19%)
		ANK repeat	414..479	CDD:293786	13/64 (20%)
		ANK repeat	419..445	CDD:293786	5/25 (20%)
		Ank_2	420..511	CDD:289560	16/90 (18%)
		ANK repeat	481..511	CDD:293786	4/29 (14%)
		Ank_2	486..>545	CDD:289560	14/60 (23%)
		ANK repeat	516..542	CDD:293786	8/27 (30%)
mib1	XP_009295119.1	MIB_HERC2	15..71	CDD:284184
		ZZ_Mind_bomb	83..127	CDD:239079
		MIB_HERC2	154..218	CDD:284184
		Ank_2	446..571	CDD:289560	33/180 (18%)
		ANK repeat	475..538	CDD:293786	17/62 (27%)
		ANK	475..503	CDD:197603	8/27 (30%)
		ANK	535..663	CDD:238125	41/151 (27%)
		ANK repeat	540..571	CDD:293786	10/53 (19%)
		Ank_2	545..637	CDD:289560	29/114 (25%)
		ANK repeat	573..604	CDD:293786	10/30 (33%)
		ANK repeat	606..640	CDD:293786	10/33 (30%)
		Ank_2	611..707	CDD:289560	26/96 (27%)
		ANK	637..790	CDD:238125	42/190 (22%)
		ANK repeat	642..674	CDD:293786	11/32 (34%)
		ANK repeat	676..707	CDD:293786	6/30 (20%)
		Ank_2	681..780	CDD:289560	27/135 (20%)
		zf-C3HC4_3	826..869	CDD:290631	10/48 (21%)
		zf-C3HC4_3	871..916	CDD:290631	12/77 (16%)
		zf-C3HC4_3	994..1037	CDD:290631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000