DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42534 and ESPNL

DIOPT Version :9

Sequence 1:NP_651560.2 Gene:CG42534 / 43298 FlyBaseID:FBgn0260487 Length:1555 Species:Drosophila melanogaster
Sequence 2:NP_919288.2 Gene:ESPNL / 339768 HGNCID:27937 Length:1005 Species:Homo sapiens


Alignment Length:1297 Identity:257/1297 - (19%)
Similarity:378/1297 - (29%) Gaps:529/1297 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 AEGCTSLMYACQRG--DIVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAI 183
            |.|...:.:|.:.|  |.|:.|.|..:.|    ...|:|..|         ..:.|..|..|:| 
Human    34 ALGAGLVHHATRAGHLDCVKFLVQRAQLP----GNQRAHNGA---------TPAHDAAATGSLA- 84

  Fly   184 AAPEL----------LESADEDGFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATV 238
               ||          |:..|..|.:|||||...|:..:|..||          :||||    ||:
Human    85 ---ELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLL----------HEGHS----ATL 132

  Fly   239 CGEVESLRAVLAAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLSH 303
                               ....|..|||:|| :.|                  .|..|.:|.:.
Human   133 -------------------ETREGARPLHHAA-VSG------------------DLTCLKLLTAA 159

  Fly   304 PQSSVDVQDKDGRQPLLWAASAGSAKAVIALVK-AGARVESSDKDGLTALHCAGSRGHTECIDTL 367
            ..|||:.:.:.|..||..|...|.......||| .||.|.....||::|||.|.:|||...:..|
Human   160 HGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWL 224

  Fly   368 IGLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLK 432
            :..........|:.|.||||:|...||.....|||.:           .||.             
Human   225 VTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLM-----------GTPI------------- 265

  Fly   433 LLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDM 497
                      ||::.|..|||:||.:|:.|..:.|::.. ...:....||.:...:|..:.:.|.
Human   266 ----------LRDSWGGTPLHDAAENGQMECCQTLVSHH-VDPSLRDEDGYTAADLAEYHGHRDC 319

  Fly   498 CKLLLDYGADVNAVYRNSRGLVLTP------------LDGALQRGHRSTAKFLQANGGQPAN--K 548
            .:.|.:....|        .|::||            ...:|:.|.|        .|..|.|  .
Human   320 AQYLREVAQPV--------PLLMTPPPPPFPPPPLLATRRSLEDGRR--------GGPGPGNPSP 368

  Fly   549 VRLSSRRTGNPFHETNATDMVRPLKYVEKEELHDLRSSKKYVVYLKRSDSDNGNENGKA-DVGDG 612
            :.||....|:|........|..|              :...::....:|.: |.|...| |..||
Human   369 MSLSPAWPGHPDQPLPREQMTSP--------------APPRIITSATADPE-GTETALAGDTSDG 418

  Fly   613 DCSCSEQTYRKEQRLRHVCRRHKRRQLRRRTSSCGE------SKHERCSEICRSKSNIEIRRRKS 671
            ..:.                     ||....|  |:      ::.||...|...|..:.:|:.::
Human   419 LAAL---------------------QLDGLPS--GDIDGLVPTRDERGQPIPEWKRQVMVRKLQA 460

  Fly   672 RERYASSSEWEEESAEDSCENCCYHKRQKDRVVNRKRSTSSRKSKNRDSSDPDEK---NHSENHS 733
            |....||:|     |:|                            |..||.|.|:   .:|:.|.
Human   461 RLGAESSAE-----AQD----------------------------NGGSSGPTEQAAWRYSQTHQ 492

  Fly   734 SPEKGSRKPLAVNGDHQADNGKDQTSTKERPPSASRHQTPPTKEGTFIKSPTQSAKSEKSGQMDN 798
            :                                              |..|.....:|     |:
Human   493 A----------------------------------------------ILGPFGELLTE-----DD 506

  Fly   799 LLVEESHAVELTDEEQEAAKSVVTQVDVHHDAEEIQTSKSSEEAPQAEENGKEKESE-----QEV 858
            |:..|....:|                                  |.....:|.|||     .|:
Human   507 LVYLEKQIADL----------------------------------QLRRRCQEYESELGRLAAEL 537

  Fly   859 KLQLSEEETQLVS-------------KEVEQVIIIAATALSSESKSSSEEKSVEKELPKEGQAPG 910
            :..|.|   .|||             .|||:..|.||     |...|:|...|         |||
Human   538 QALLPE---PLVSITVNSHFLPRAPGLEVEEASIPAA-----EPAGSAEASEV---------APG 585

  Fly   911 ENHDEEVKEHQNPPTPY-----------------------APPAQPSTPP--PPPKEEAAKPPSA 950
            ..           |.|:                       ....:|||.|  ...:|.:|.||.:
Human   586 VQ-----------PLPFWCSHISRLVRSLSLLLKGVHGLVQGDEKPSTRPLQDTCREASASPPRS 639

  Fly   951 AEQPQ-----PNANTVEG-MESAAAE-------PASVGKKTEQMELA--EAKPKPNT-----NPT 995
            ..|.|     .:..|:.| .|||:..       |...|.:..|....  .|.|||.:     .|.
Human   640 EAQRQIQEWGVSVRTLRGNFESASGPLCGFNPGPCEPGAQHRQCLSGCWPALPKPRSGLASGEPR 704

  Fly   996 P---------------IPPPTAAPPGPPSAESKK----------------PPAAP---------- 1019
            |               :|....|..||..|..:|                .||..          
Human   705 PGDTEEASDSGISCEEVPSEAGAAAGPDLASLRKERIIMLFLSHWRRSAYTPALKTVACRTLGAR 769

  Fly  1020 ------QPRPSTPQTPTPPQPEP------PQREQETR-----------------RSFTLLPSDSA 1055
                  |....:|..|:||...|      .||...|.                 |..:..|..:.
Human   770 HAGLRGQEAARSPGPPSPPSEGPRLGHLWQQRSTITHLLGNWKAIMAHVPARQLRRLSRQPRGAL 834

  Fly  1056 DDDPVLNPNSNPPASASDEPAGERK------SSFHVLKSDDSLDESTKRPGRKVDYEAGNQVFQV 1114
            ..:..|     |....:..|.....      ..|.:|:.|...:|      ||:.:....:||:.
Human   835 SPEQFL-----PHVDGAPVPYSSLSLDLFMLGYFQLLECDLPAEE------RKLRHLLCFEVFEH 888

  Fly  1115 VG-EGASAVQLPSAAELEKMDYEYEEYDDEYDDDERDGIDPEHDSALRRFLSSGNRHG----VGN 1174
            :| .|..||:....|..:::......:.|.::|.:            .||..|..|..    .|.
Human   889 LGTHGWEAVRAFHKAVTDEVAAGRRAWTDGFEDIK------------ARFFGSSQRPAWDTEPGR 941

  Fly  1175 SSAAGGAAAAG----ASIADDTCEGSGGRKRRLKKRVRSG-----------NKTRSNWKNSQ 1221
            .|   |....|    |::   .|.|.....:||..|.:.|           |::.:.||..:
Human   942 KS---GLTLLGPLPHAAV---PCSGPEPTAQRLGSRSQQGSFNGEDICGYINRSFAFWKEKE 997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42534NP_651560.2 Ank_2 127..226 CDD:289560 28/110 (25%)
ANK 193..335 CDD:238125 35/141 (25%)
ANK repeat 195..226 CDD:293786 10/30 (33%)
Ank_5 214..269 CDD:290568 12/54 (22%)
ANK repeat 228..259 CDD:293786 6/30 (20%)
ANK repeat 314..345 CDD:293786 11/31 (35%)
Ank_2 319..412 CDD:289560 31/93 (33%)
ANK 345..468 CDD:238125 34/122 (28%)
ANK repeat 347..379 CDD:293786 10/31 (32%)
ANK repeat 381..412 CDD:293786 11/30 (37%)
ANK 409..538 CDD:238125 25/140 (18%)
ANK repeat 414..479 CDD:293786 13/64 (20%)
ANK repeat 419..445 CDD:293786 1/25 (4%)
Ank_2 420..511 CDD:289560 17/90 (19%)
ANK repeat 481..511 CDD:293786 6/29 (21%)
Ank_2 486..>545 CDD:289560 11/70 (16%)
ANK repeat 516..542 CDD:293786 6/37 (16%)
ESPNLNP_919288.2 ANK 1 1..31
Ank_4 8..56 CDD:290365 6/21 (29%)
ANK <8..56 CDD:295348 6/21 (29%)
ANK 2 35..64 8/32 (25%)
Ank_2 41..133 CDD:289560 34/141 (24%)
ANK repeat 69..101 CDD:293786 8/44 (18%)
ANK 3 69..99 8/42 (19%)
ANK 100..225 CDD:238125 50/176 (28%)
ANK repeat 103..134 CDD:293786 16/63 (25%)
ANK 4 103..132 15/42 (36%)
Ank_2 108..201 CDD:289560 38/144 (26%)
ANK repeat 136..168 CDD:293786 13/50 (26%)
ANK 5 136..166 13/48 (27%)
ANK 165..291 CDD:238125 45/159 (28%)
ANK repeat 170..201 CDD:293786 11/30 (37%)
ANK 6 170..200 11/29 (38%)
ANK 7 204..234 10/29 (34%)
Ank_2 209..301 CDD:289560 32/126 (25%)
ANK repeat 238..268 CDD:293786 14/63 (22%)
ANK 8 238..267 13/62 (21%)
ANK repeat 270..301 CDD:293786 9/31 (29%)
ANK 9 270..299 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..444 27/156 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 462..483 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..644 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..730 4/34 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 773..795 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X100
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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