DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and Invs

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_038965783.1	Gene:	Invs / 313228	RGDID:	1563359	Length:	1077	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	228/972 - (23%)
Similarity:	343/972 - (35%)	Gaps:	308/972 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 DAAAEAAVDVPETDPDPAQLTVSQSQSSSTVARRRLAEGCTSLMYACQRG--------------- 134
            ||..:|..||.:||.                :||      |:|..|.|:|
  Rat    65 DALLKAGADVNKTDH----------------SRR------TALHLAAQKGNYRFMKLLLTRRANW 107

  Fly   135 ---DIVQV----LAQMREKPELLR------------QRDRSHRNALHYCA--------------- 165
               |:.::    |:.....|:.|.            .:|::.:.|||:.|
  Rat   108 MQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHD 172

  Fly   166 ----AQDSEGSKDLVAAAS------------IAIAAP--ELLESADEDGFTPLHLAVIQGNLAMV 212
                ..|.||...|..||:            |..|||  .||...|.:|.||||.||..|||.:|
  Rat   173 SNIGIPDVEGKIPLHWAANHKDASAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVV 237

  Fly   213 NLLLA-NKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKP-DANGGTPLHYAAQMCGA 275
            ::|.: ...::.:.||...:.:|||.:.|..:.:..:|....|...| |:.|.||||||||...|
  Rat   238 DVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTVPSDSQGATPLHYAAQSNFA 302

  Fly   276 ----SKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGS---AKAVIA 333
                ...|.....:.||...|. |.:.:.|:|| |..|..|.:||...:|||..||   .:.:::
  Rat   303 VLHYHGPDVPHHCAVSNKVFLQ-ETVKVFLTHP-SVRDDSDLEGRTSFMWAAGKGSDDVLRTMLS 365

  Fly   334 LVKAGARVESSDKDGLTALHCAG---------------------------------SRGHTECID 365
            | |:...:..:||.|.||||.|.                                 ..||.:.|.
  Rat   366 L-KSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQ 429

  Fly   366 TLI-GLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFE 429
            ||| |  ||..||:|.:|.:.||:|...|:||....|::.:.:||.||..||||..|....|...
  Rat   430 TLIKG--GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYIN 492

  Fly   430 TLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDY 494
            .:.:|.|..|:                                  .|....:||:.||.:..|.|
  Rat   493 CMAVLMENNAD----------------------------------PNIQDKEGRTALHWSCNNGY 523

  Fly   495 TDMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRSTAKFLQANGG---------------- 543
            .|..|||||:.|..|.:..|...  .||||.||........:|:..:|.
  Rat   524 LDAIKLLLDFAAFPNQMENNEER--YTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQA 586

  Fly   544 -QPANKVRLSSRRTGNPFHETNATDMVRPLKYVEKEELHDLRSSKKYVVYLKRSDSDNGNENGKA 607
             ....|||.:.|...|              ..::.|:|....::||.....||.:::   :.|:.
  Rat   587 VYKGYKVRKAFRDRKN--------------LLMKHEQLRKDAAAKKREEENKRKEAE---QKGQP 634

  Fly   608 DVGDG-----DCSCSEQTY--------RKEQRLRHVCRRHKRRQLRRRTSSCGESKHERCSEICR 659
            |....     .|..|.|..        .|:....|..:.....|.|......|.:.|..||
  Rat   635 DTDPPRPQVLPCPPSPQNEPSRQSAAPSKQPPASHTVQSPDPEQGRPAGQCPGRASHRDCS---- 695

  Fly   660 SKSNIEIRRRKSRERYASSSEWEEESAEDSCENCC--YHKRQ-KDRVVNRKRSTSSRKSKNRDSS 721
              |:::          .::|....||..:.|....  .|.|. :|....|.:.|||.:....::|
  Rat   696 --SDLQ----------GTASRKPSESPREHCRGASAGVHPRSCEDGDSYRHQGTSSAEKCRGETS 748

  Fly   722 DPDEKNHSENHSSPEKGSRKPLAVNGDHQADNGKDQT------STKERPPSASRHQT-PPTKEGT 779
            .    .|......|.: :|:|::......|:.|:|.:      |.::||...|:.|. .|...|.
  Rat   749 G----EHQRCEQGPSR-ARQPVSTGSAGPAEKGEDSSPAITSASQRDRPRKPSKRQDGAPRSRGA 808

  Fly   780 FIKSPTQS-------AKSEKSGQMDNLLVEESHAVELTDEEQEAAKSVVTQVD---VHHDAEEIQ 834
            ..|..|..       |.|.:.|                     :||:.|.:.|   ||||....:
  Rat   809 SQKRRTHQLRDRCSPAGSSRPG---------------------SAKAEVARADQSSVHHDTPRNK 852

  Fly   835 TSKS------SEEAPQAEE---NGKEKESE-----------------QEVKLQLSEEETQLV 870
            .::.      |.:.|.:.|   :|.:|..|                 |.|.:.|...|.:|:
  Rat   853 VTQDKLVGGVSSDVPLSTEELGSGCQKLYEDLCASPENNVAHGPRPGQSVNIHLLPVEQRLL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	38/166 (23%)
		ANK	193..335	CDD:238125	51/150 (34%)
		ANK repeat	195..226	CDD:293786	12/31 (39%)
		Ank_5	214..269	CDD:290568	16/56 (29%)
		ANK repeat	228..259	CDD:293786	7/31 (23%)
		ANK repeat	314..345	CDD:293786	9/33 (27%)
		Ank_2	319..412	CDD:289560	37/129 (29%)
		ANK	345..468	CDD:238125	41/156 (26%)
		ANK repeat	347..379	CDD:293786	17/65 (26%)
		ANK repeat	381..412	CDD:293786	10/30 (33%)
		ANK	409..538	CDD:238125	34/128 (27%)
		ANK repeat	414..479	CDD:293786	10/64 (16%)
		ANK repeat	419..445	CDD:293786	5/25 (20%)
		Ank_2	420..511	CDD:289560	20/90 (22%)
		ANK repeat	481..511	CDD:293786	14/29 (48%)
		Ank_2	486..>545	CDD:289560	21/75 (28%)
		ANK repeat	516..542	CDD:293786	7/25 (28%)
Invs	XP_038965783.1	Ank_5	33..88	CDD:404699	11/44 (25%)
		ANK repeat	47..78	CDD:293786	5/12 (42%)
		PHA02874	<62..>262	CDD:165205	51/218 (23%)
		ANK repeat	80..111	CDD:293786	7/36 (19%)
		ANK repeat	113..146	CDD:293786	3/32 (9%)
		ANK repeat	150..179	CDD:293786	4/28 (14%)
		ANK repeat	181..218	CDD:293786	11/36 (31%)
		ANK repeat	220..252	CDD:293786	12/31 (39%)
		ANKYR	<252..400	CDD:223738	48/150 (32%)
		ANK repeat	254..286	CDD:293786	7/31 (23%)
		ANK repeat	343..376	CDD:293786	9/33 (27%)
		Ank_2	358..>576	CDD:423045	67/256 (26%)
		ANK repeat	378..409	CDD:293786	6/30 (20%)
		ANK repeat	411..442	CDD:293786	11/32 (34%)
		ANK repeat	444..475	CDD:293786	10/30 (33%)
		ANK repeat	477..508	CDD:293786	10/64 (16%)
		ANK repeat	510..538	CDD:293786	13/27 (48%)
		ANK repeat	543..570	CDD:293786	8/28 (29%)
		PHA03307	634..>899	CDD:223039	58/306 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000