DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and Mib1

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_001100875.1	Gene:	Mib1 / 307594	RGDID:	1307195	Length:	1006	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	166/741 - (22%)
Similarity:	270/741 - (36%)	Gaps:	199/741 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QQRQEAADKVIAMPGSSQDTDAAAEAAVDVPETDPDPAQLTVSQSQSSSTVARRRLAEGCTSLMY 129
            ||....:|..:.:.|:|...:.||.:.|       .||..|:|.:..      .||::....|..
  Rat   373 QQIYSDSDLKVEVCGTSWTYNPAAVSKV-------APAGSTISNASG------ERLSQLLKKLFE 424

  Fly   130 ACQRGDIVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAA--PELLESA 192
            ..:.||:                                   :::||.||:....|  .:||:..
  Rat   425 TQESGDL-----------------------------------NEELVKAAANGDVAKVEDLLKRP 454

  Fly   193 DED------GFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAA 251
            |.|      |.|.:..|...|::.::.|||....||.|.|.:|...||.|.. |:..::..||..
  Rat   455 DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAF-GDEGAVIEVLHR 518

  Fly   252 GASVAKPDANG-----GTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGILLS---HPQSSV 308
            |::    |.|.     .||||.|.                   ::..|:::..||.   ||
  Rat   519 GSA----DLNARNKRRQTPLHIAV-------------------NKGHLQVVKTLLDFGCHP---- 556

  Fly   309 DVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGA 373
            .:||.:|..||..|.|......:..|::|||.|..::.:|..|||.|..||:...:..|:.....
  Rat   557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPR 621

  Fly   374 P--TDLIDSNGCTALHYAVTLGHADATARLLDLEADPNR--QDRKGRTPAHCGCSKGQFETLKLL 434
            |  .|....:|.||||.|....|.: .|.||..:.:.|.  |:...:|..|....:...:.::||
  Rat   622 PWIVDEKKDDGYTALHLAALNNHVE-VAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLL 685

  Fly   435 KERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCK 499
            ...||.|.:::..||.|||||...                        .:|..:....|..|:.|
  Rat   686 VRAGAKLDIQDKDGDTPLHEALRH------------------------HTLSQLRQLQDMQDVGK 726

  Fly   500 LLLDYGADVNAVYRNSRGLVLTPL--DGALQRGHRSTAKFLQANGGQPANKVRLSSRRTGNPFHE 562
                    |:|.:..|:..::..|  .||.::...|.|.||.|||..    :.:.:::..:|...
  Rat   727 --------VDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGAD----LSIRNKKGQSPLDL 779

  Fly   563 TNATDMVRPLKYVEKEELHDLRSSKKYVVYLKRSDSDNGNE-----NGKADVGDGDC----SCSE 618
            .....:.:.|....||::.....|:.  ..:..:||:...|     :.|.|...|.|    :||.
  Rat   780 CPDPSLCKALAKCHKEKVSGQVGSRS--PSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSL 842

  Fly   619 QTYRKEQRLRHVCRRHKRRQLRRRTS-----SCGESK----HERCSEICRSKSNIEIRRRKSRER 674
            .:.|.::.|  :|    :.|::.||.     .|.:.|    .:.|..:|
  Rat   843 CSPRVKKCL--IC----KEQVQSRTKIEECVVCSDKKAAVLFQPCGHMC---------------- 885

  Fly   675 YASSSEWEEESAEDSCENCC--YHKRQKDRVVNRKRSTSSRKSKNRDSSDPDEKNHSENHSSPEK 737
                          :||||.  ..|..:.|.|..:|.........:.|.:|.:...|.|....:|
  Rat   886 --------------ACENCASLMKKCVQCRAVVERRVPFITCCGGKSSEEPSDDISSGNIPVLQK 936

  Fly   738 GSRKPLAVNGD-----HQADNGKDQT 758
             .:....||.|     .|..:.|:||
  Rat   937 -DKDNTNVNADVQKLQQQLQDIKEQT 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	22/106 (21%)
		ANK	193..335	CDD:238125	40/155 (26%)
		ANK repeat	195..226	CDD:293786	11/36 (31%)
		Ank_5	214..269	CDD:290568	21/59 (36%)
		ANK repeat	228..259	CDD:293786	8/30 (27%)
		ANK repeat	314..345	CDD:293786	10/30 (33%)
		Ank_2	319..412	CDD:289560	29/96 (30%)
		ANK	345..468	CDD:238125	36/126 (29%)
		ANK repeat	347..379	CDD:293786	10/33 (30%)
		ANK repeat	381..412	CDD:293786	11/32 (34%)
		ANK	409..538	CDD:238125	28/132 (21%)
		ANK repeat	414..479	CDD:293786	14/64 (22%)
		ANK repeat	419..445	CDD:293786	6/25 (24%)
		Ank_2	420..511	CDD:289560	18/90 (20%)
		ANK repeat	481..511	CDD:293786	5/29 (17%)
		Ank_2	486..>545	CDD:289560	16/60 (27%)
		ANK repeat	516..542	CDD:293786	8/27 (30%)
Mib1	NP_001100875.1	MIB_HERC2	15..72	CDD:399589
		ZZ_Mind_bomb	83..127	CDD:239079
		MIB_HERC2	154..218	CDD:399589
		SH3_15	246..311	CDD:408152
		SH3_15	333..397	CDD:408152	6/23 (26%)
		PHA03095	439..>710	CDD:222980	85/323 (26%)
		ANK repeat	464..494	CDD:293786	10/29 (34%)
		ANK repeat	496..560	CDD:293786	20/91 (22%)
		ANK repeat	562..593	CDD:293786	10/30 (33%)
		ANK repeat	631..663	CDD:293786	11/32 (34%)
		ANK repeat	665..696	CDD:293786	7/30 (23%)
		Ank_2	670..770	CDD:403870	30/135 (22%)
		RING1-HC_MIB1	818..854	CDD:319638	10/41 (24%)
		RING2-HC_MIB1	865..901	CDD:319639	9/65 (14%)
		RING3-HC_MIB1	962..1003	CDD:319641	166/741 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000