DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and Ank1

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_038950490.1	Gene:	Ank1 / 306570	RGDID:	1309620	Length:	1946	Species:	Rattus norvegicus

Alignment Length:	1185	Identity:	262/1185 - (22%)
Similarity:	413/1185 - (34%)	Gaps:	311/1185 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 AEGCTSLMYACQRGDIVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAA 185
            |:..||.:.|.:.|::.:.|..:|...::    :..::|.|:.......||...:|    :.:..
  Rat    57 ADAATSFLRAARSGNLDKALDHLRNGVDI----NTCNQNGLNGLHLASKEGHVKMV----VELLH 113

  Fly   186 PE-LLESADEDGFTPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVL 249
            .| :||:..:.|.|.||:|.:.|...:|..|:...|:|||...:|.:.::.|.....:|.::.:|
  Rat   114 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 178

  Fly   250 AAGASVAKPDANGGTPLHYAAQM------------------------CGASKQDSKQQA----SS 286
            ..||:......:|.|||..|.|.                        ..|...|::..|    :.
  Rat   179 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 243

  Fly   287 SNSSRLS---------------LEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVK 336
            .|...||               |.:..:||:. .:||:...::|..||..|:..|:...|..|:.
  Rat   244 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLD 307

  Fly   337 AGARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSNG--------------C---- 383
            .||::|:..||.||.||||...||....:.|:. .|||......||              |
  Rat   308 RGAQIETRTKDELTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 371

  Fly   384 ---------------TALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKL 433
                           |.||.|...||......|||..|.||.:...|.||.|..|.|.....::|
  Rat   372 LQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMEL 436

  Fly   434 LKERGA--------------------------NLWLR-------NAKGDLPLHEAAASGRRELLE 465
            |.:.||                          ||..|       |.|.:.|||.||.:|..|:.:
  Rat   437 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 501

  Fly   466 WLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRG 530
            :||..:.| .|..:.|.::.||.||...:|.|.||||:..|..|.......    |||..|.:.|
  Rat   502 YLLQNKAK-ANAKAKDDQTPLHCAARIGHTSMVKLLLENDASPNLATTAGH----TPLHTAAREG 561

  Fly   531 HRSTA-KFLQANGGQPANKVRLSSRRTGNPFHETNATDMVRPLKYVEKEELHDLRSSKKYVVYLK 594
            |..|| ..|:....|..     .:::...|.|.......||..:.:.:.:.|...:.|
  Rat   562 HVDTALALLEKEASQAC-----MTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGK------- 614

  Fly   595 RSDSDNGNENGKADVGDGDCSCSEQTYRKEQRLRHVCRRHKRRQLRRRTSSCGESKHERC----- 654
                     ||...:                   ||...|....:.:.....|.|.|...
  Rat   615 ---------NGLTPL-------------------HVAVHHNNLDIVQLLLPRGGSPHSPAWNGYT 651

  Fly   655 -SEICRSKSNIEIRRRKSRERYASSSEWEE-----------ESAEDSCENCCYHKRQKDRVVNRK 707
             ..|...::.||:.|  |..:|..|:..|.           :............|:....:.|:.
  Rat   652 PLHIAAKQNQIEVAR--SLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKS 714

  Fly   708 RST-------------SSRKSKNRDSSDPDEK-NHSENHSSPEKGSRKPLAVNGDHQAD-NGKDQ 757
            ..|             :....|:..:.|...: .::..|.:...|:.|.:.....|||| |.|
  Rat   715 GLTPLHLVAQEGHVPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-- 777

  Fly   758 TSTKERPPSASRHQTPPTKEGTFIKSPTQSAKSEKSGQMDNLLVEESHAVELTDEEQEAAKSVVT 822
                             ||.|   .||...|..:....:..||::...:      ..|.:.:..|
  Rat   778 -----------------TKLG---YSPLHQAAQQGHTDIVTLLLKNGAS------PNEVSSNGTT 816

  Fly   823 QVDVHH--------DAEEIQTSKSSEEAPQAEENGKEKESEQEVKLQLSEEE-TQLVSKEVEQVI 878
            .:.:..        |..::.|.::|......:......|:..|: |.:||:| |..:|...::
  Rat   817 PLAIAKRLGYISVTDVLKVVTDETSVVLVSDKHRMSYPETVDEI-LDVSEDEGTAHISLTGDE-- 878

  Fly   879 IIAATALSSESKSSSEEKSVEKELPKEGQAPGENHDEEVKEHQNPPTPYAPPAQPSTP--PPPPK 941
            ::.:.|...:|:...|||.:...:||..|..           ::|..|..|...|.|.  ....:
  Rat   879 LVGSKAERRDSRDVGEEKELLDFVPKLDQVV-----------ESPAIPRIPCVTPETVVIRSEDQ 932

  Fly   942 EEAAK--------PPSAAEQPQPNANTVEGMESAAAEPASVGKKTEQMELAEAK------PKPNT 992
            |:|:|        |.|.|.:...|.:.|       |.|...|.....|  .:|:      .:.|.
  Rat   933 EQASKEYDEDSLIPSSPATETSDNISPV-------ASPVHTGFLVSFM--VDARGGSMRGSRHNG 988

  Fly   993 NPTPIPPPTAAPPGPPSAESKKPPAAPQPRPSTPQTPTPPQPEPPQREQE--TRRSFTLLPSDSA 1055
            ....|||.|.|.|...:....||     .:.|||         ||..|:|  ..|...|.|:.:.
  Rat   989 LRVVIPPRTCAAPTRITCRLVKP-----QKLSTP---------PPLAEEEGLASRIIALGPTGAQ 1039

  Fly  1056 DDDPVLNPNSNPPASASDEPAGERKSSFHVLKSDDS--LDESTKRPGRK-VDYEAGNQVFQVVGE 1117
            ...||:   ...|..|| ...|:|:  ..||:|::.  ..|...|.|.. :|     |:...:.|
  Rat  1040 FLSPVI---VEIPHFAS-HGRGDRE--LVVLRSENGSVWKEHKSRYGESYLD-----QILNGMDE 1093

  Fly  1118 GASAVQLPSAAELEK 1132
                 :|.|..||||
  Rat  1094 -----ELGSLEELEK 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	24/99 (24%)
		ANK	193..335	CDD:238125	41/184 (22%)
		ANK repeat	195..226	CDD:293786	12/30 (40%)
		Ank_5	214..269	CDD:290568	15/54 (28%)
		ANK repeat	228..259	CDD:293786	6/30 (20%)
		ANK repeat	314..345	CDD:293786	10/30 (33%)
		Ank_2	319..412	CDD:289560	37/125 (30%)
		ANK	345..468	CDD:238125	51/188 (27%)
		ANK repeat	347..379	CDD:293786	13/31 (42%)
		ANK repeat	381..412	CDD:293786	15/63 (24%)
		ANK	409..538	CDD:238125	48/162 (30%)
		ANK repeat	414..479	CDD:293786	26/97 (27%)
		ANK repeat	419..445	CDD:293786	10/58 (17%)
		Ank_2	420..511	CDD:289560	36/123 (29%)
		ANK repeat	481..511	CDD:293786	13/29 (45%)
		Ank_2	486..>545	CDD:289560	21/59 (36%)
		ANK repeat	516..542	CDD:293786	9/26 (35%)
Ank1	XP_038950490.1	ANK repeat	61..89	CDD:293786	6/31 (19%)
		Ank_2	63..154	CDD:403870	23/98 (23%)
		ANK repeat	91..122	CDD:293786	8/34 (24%)
		ANK repeat	125..155	CDD:293786	12/29 (41%)
		PHA02876	<137..>482	CDD:165207	81/346 (23%)
		ANK repeat	157..188	CDD:293786	6/30 (20%)
		ANK repeat	190..214	CDD:293786	6/23 (26%)
		ANK repeat	223..250	CDD:293786	4/26 (15%)
		ANK repeat	253..283	CDD:293786	5/30 (17%)
		ANK repeat	285..316	CDD:293786	10/30 (33%)
		ANK repeat	318..349	CDD:293786	13/31 (42%)
		ANK repeat	351..382	CDD:293786	3/30 (10%)
		ANK repeat	387..415	CDD:293786	12/27 (44%)
		ANK repeat	417..448	CDD:293786	10/30 (33%)
		PHA02875	429..>639	CDD:165206	54/254 (21%)
		ANK repeat	450..481	CDD:293786	3/30 (10%)
		ANK repeat	483..514	CDD:293786	12/31 (39%)
		ANK repeat	516..545	CDD:293786	12/28 (43%)
		ANK repeat	550..580	CDD:293786	10/38 (26%)
		ANK repeat	582..613	CDD:293786	5/30 (17%)
		Ank_2	593..>806	CDD:423045	42/271 (15%)
		ANK repeat	615..643	CDD:293786	7/46 (15%)
		ANK repeat	648..679	CDD:293786	7/32 (22%)
		ANK repeat	681..712	CDD:293786	1/30 (3%)
		ANK repeat	714..745	CDD:293786	3/30 (10%)
		ANK repeat	747..778	CDD:293786	9/49 (18%)
		ANK repeat	780..808	CDD:293786	6/36 (17%)
		Ank_4	781..833	CDD:372654	9/60 (15%)
		ZU5	966..1070	CDD:128514	32/125 (26%)
		UPA_2	1291..1420	CDD:375346
		Death_ank1	1456..1539	CDD:260067
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910