DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and ANK3

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens

Alignment Length:	569	Identity:	138/569 - (24%)
Similarity:	224/569 - (39%)	Gaps:	170/569 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 EKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELLESAD------------EDGF 197
            |:||    :.|.||.     .::|.:...|..|:...|..|..|.::.|            ::|.
Human    20 EEPE----KKRKHRK-----RSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGL 75

  Fly   198 TPLHLAVIQGNLAMVNLLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPDANG 262
            ..||||..:|::.:|:.||..:|:|:|...:|::.:|.|::.|:.|.::.::..||:|.....||
Human    76 NALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNG 140

  Fly   263 GTPLHYAAQ---------------------------MCGASKQDSKQQAS----SSNSSRLSLEI 296
            .|||:.|||                           :..|.:|...|..|    :....::.|..
Human   141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA 205

  Fly   297 LGI-----------LLSHPQSSVDVQDKDGRQPLLWAA--------------------------- 323
            |.|           ||....::.||:.|.|..||..||
Human   206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT 270

  Fly   324 ------SAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGHTECIDTLI------------GL 370
                  ..|:|..|..|:..||::::..:||||.|||....||.:.::.|:            ||
Human   271 PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL 335

  Fly   371 -------------C-------GAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKG 415
                         |       ..|.|.:.::..||||.|...||......|||.:|:||.:...|
Human   336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400

  Fly   416 RTPAHCGCSKGQFETLKLLKERGANLW---------------------------------LRNAK 447
            .||.|..|.|.:.:.::||.:.||::.                                 ..|.:
Human   401 FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465

  Fly   448 GDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVY 512
            |:..||.||.||:.|::.:|: |...||...:.|.::.|||:|.....|:.:.||..||..||..
Human   466 GETALHMAARSGQAEVVRYLV-QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529

  Fly   513 RNSRGLVLTPLDGALQRGHRSTAKFLQANGGQPANKVRLSSRRTGNPFH 561
            .:.    .|||..:.:.||...|.||..:|.    .:.:::::...|.|
Human   530 TSG----YTPLHLSAREGHEDVAAFLLDHGA----SLSITTKKGFTPLH 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	25/92 (27%)
		ANK	193..335	CDD:238125	49/228 (21%)
		ANK repeat	195..226	CDD:293786	12/30 (40%)
		Ank_5	214..269	CDD:290568	18/54 (33%)
		ANK repeat	228..259	CDD:293786	8/30 (27%)
		ANK repeat	314..345	CDD:293786	11/63 (17%)
		Ank_2	319..412	CDD:289560	37/157 (24%)
		ANK	345..468	CDD:238125	47/187 (25%)
		ANK repeat	347..379	CDD:293786	15/63 (24%)
		ANK repeat	381..412	CDD:293786	13/30 (43%)
		ANK	409..538	CDD:238125	42/161 (26%)
		ANK repeat	414..479	CDD:293786	23/97 (24%)
		ANK repeat	419..445	CDD:293786	7/58 (12%)
		Ank_2	420..511	CDD:289560	31/123 (25%)
		ANK repeat	481..511	CDD:293786	11/29 (38%)
		Ank_2	486..>545	CDD:289560	20/58 (34%)
		ANK repeat	516..542	CDD:293786	8/25 (32%)
ANK3	NP_066267.2	ANK 6	234..263		5/28 (18%)
		ANK repeat	267..298	CDD:293786	6/30 (20%)
		ANK 7	267..296		6/28 (21%)
		Ank_2	272..363	CDD:289560	21/90 (23%)
		ANK	295..420	CDD:238125	35/124 (28%)
		ANK 8	300..329		10/28 (36%)
		ANK repeat	300..325	CDD:293786	10/24 (42%)
		ANK repeat	333..364	CDD:293786	5/30 (17%)
		ANK 9	333..362		4/28 (14%)
		ANK	361..486	CDD:238125	33/124 (27%)
		ANK 10	366..395		12/28 (43%)
		ANK repeat	369..397	CDD:293786	13/27 (48%)
		Ank_2	371..463	CDD:289560	21/91 (23%)
		ANK repeat	399..430	CDD:293786	10/30 (33%)
		ANK 11	399..428		10/28 (36%)
		ANK repeat	432..463	CDD:293786	0/30 (0%)
		ANK 12	432..461		0/28 (0%)
		ANK	460..585	CDD:238125	36/120 (30%)
		ANK repeat	465..496	CDD:293786	12/31 (39%)
		ANK 13	465..494		12/29 (41%)
		Ank_2	470..561	CDD:289560	32/99 (32%)
		ANK repeat	498..529	CDD:293786	12/30 (40%)
		ANK 14	498..527		10/28 (36%)
		ANK repeat	531..560	CDD:293786	9/36 (25%)
		ANK 15	531..560		9/36 (25%)
		Ank_2	536..626	CDD:289560	9/39 (23%)
		ANK	560..684	CDD:238125	2/11 (18%)
		ANK repeat	564..593	CDD:293786	2/7 (29%)
		ANK 16	564..593		2/7 (29%)
		ANK repeat	597..626	CDD:293786
		ANK 17	597..626
		ANK repeat	630..660	CDD:293786
		ANK 18	630..659
		Ank_4	631..684	CDD:290365
		ANK	658..783	CDD:238125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		8/32 (25%)
		Ank_4	47..94	CDD:290365	11/46 (24%)
		ANK	68..193	CDD:238125	32/124 (26%)
		ANK repeat	73..104	CDD:293786	12/30 (40%)
		ANK 1	73..102		11/28 (39%)
		Ank_2	78..164	CDD:289560	27/85 (32%)
		ANK repeat	106..137	CDD:293786	8/30 (27%)
		ANK 2	106..135		8/28 (29%)
		ANK 3	139..168		8/28 (29%)
		ANK repeat	139..164	CDD:293786	8/24 (33%)
		Ank_4	140..193	CDD:290365	11/52 (21%)
		ANK 4	172..201		4/28 (14%)
		ANK 5	203..230		5/26 (19%)
		ANK repeat	205..232	CDD:293786	6/26 (23%)
		Ank_2	206..297	CDD:289560	18/90 (20%)
		ANK	229..354	CDD:238125	27/124 (22%)
		ANK repeat	234..265	CDD:293786	5/30 (17%)
		ANK repeat	663..694	CDD:293786
		ANK 19	663..692
		Ank_2	669..759	CDD:289560
		ANK repeat	696..727	CDD:293786
		ANK 20	696..725
		ANK repeat	729..760	CDD:293786
		ANK 21	729..758
		Ank_5	749..803	CDD:290568
		ANK 22	762..791
		ANK repeat	762..790	CDD:293786
		ANK 23	795..825
		ZU5	982..1086	CDD:128514
UPA domain. /evidence=ECO:0000250	1273..1407
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090
Death_ank3	4088..4171	CDD:176781
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910