DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42534 and ANK1

DIOPT Version :9

Sequence 1:NP_651560.2 Gene:CG42534 / 43298 FlyBaseID:FBgn0260487 Length:1555 Species:Drosophila melanogaster
Sequence 2:XP_011542792.1 Gene:ANK1 / 286 HGNCID:492 Length:1969 Species:Homo sapiens


Alignment Length:1266 Identity:285/1266 - (22%)
Similarity:459/1266 - (36%) Gaps:305/1266 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 AKKQLQFESPLPRRTRTMQQQQQQDNDHPPQQEKQE----QQQQQQQRQEAADKVIAM--PGSSQ 82
            |.|||       ::.:.::.|..|:     |:||:|    ::.:.:.|::.||...:.  ...|.
Human     4 AAKQL-------KKIKDIEAQALQE-----QKEKEESNRKRRNRSRDRKKKADAATSFLRAARSG 56

  Fly    83 DTDAAAE---AAVDVPETDPDPA--------QLTVSQSQSSSTVA--RRRLAEGCTSLMYACQRG 134
            :.|.|.:   ..||:...:..|:        :..:|||.....|.  :.|...|...|..|.:.|
Human    57 NLDKALDHLRNGVDINTCNQGPSASAVDLLLRCRISQSTGLLRVLYNQNRKKNGLNGLHLASKEG 121

  Fly   135 DIVQVLAQMREKPELLRQRDRSHRNALHYCA-AQDSEGSKDLV------------AAASIAIAAP 186
            . |:::.::..|..:|....:....|||..| |...|..::||            ....:.:||.
Human   122 H-VKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 185

  Fly   187 E--------LLES------ADEDGFTPLHLAVIQG----------------------NLAMVN-- 213
            |        |||:      |.|||||||.:|:.||                      ::|..|  
Human   186 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 250

  Fly   214 -----LLLANKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKPDANGGTPLHYAAQMC 273
                 :||.|..:.:.:...|.:.:|.|.....:...:.:|..||||.....||.||||.|    
Human   251 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA---- 311

  Fly   274 GASKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAG 338
                            ||....|:..||....:.::.:.||...||..||..|..:....|:..|
Human   312 ----------------SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 360

  Fly   339 ARVESSDKDGLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSNGCTALHYAVTLGHADATARLLD 403
            |.:::..|:||:.:|.|....|.:|:..|:.. .|..|.|..:..|.||.|...||......|||
Human   361 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY-DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 424

  Fly   404 LEADPNRQDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLL 468
            ..|.||.:...|.||.|..|.|.....::||.:.||::......|..|||.|:..|...:::.||
Human   425 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 489

  Fly   469 AQRPKQVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRS 533
             ||....|.::....:.||:||...:|::.|.||...|.|||..::.:    |||..|.:.||.:
Human   490 -QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ----TPLHCAARIGHTN 549

  Fly   534 TAKFLQANGGQPANKVRLSSRRTGNPFHETNATDMVRP-LKYVEKEELHDLRSSKKYV------- 590
            ..|.|..|...|    .|::.....|.|.......|.. |..:|||......:.|.:.       
Human   550 MVKLLLENNANP----NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAK 610

  Fly   591 --------VYLKRSDSDN-GNENGKADVGDGDCSCSEQTYRKEQRLRHVCRRHKRRQLRRRTSSC 646
                    :.|:|....| ..:||...:                   ||...|....:.:.....
Human   611 YGKVRVAELLLERDAHPNAAGKNGLTPL-------------------HVAVHHNNLDIVKLLLPR 656

  Fly   647 GESKHERC------SEICRSKSNIEIRRRKSRERYASSSEWEEE--------SAEDSCENCCYHK 697
            |.|.|...      ..|...::.:|:.|  |..:|..|:..|..        :|::.      |.
Human   657 GGSPHSPAWNGYTPLHIAAKQNQVEVAR--SLLQYGGSANAESVQGVTPLHLAAQEG------HA 713

  Fly   698 RQKDRVVNRKRSTSSRKSKNRDSSDP--------------------------DEKNHSENHSSPE 736
            .....:::::   ::....|:....|                          ....::..|.:..
Human   714 EMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 775

  Fly   737 KGSRKPLAVNGDHQAD-NGKDQTSTKERPPSASRHQTPPTKEGTFIKSPTQSAKSEKSGQMDNLL 800
            .|:.|.:.....|||| |.|                   ||.|   .||...|..:....:..||
Human   776 YGNIKLVKFLLQHQADVNAK-------------------TKLG---YSPLHQAAQQGHTDIVTLL 818

  Fly   801 VEESHAVELTDEEQEAAKSVVTQVDVHH--DAEEIQTSKSSEEAPQAEENGKEKESEQEVKLQLS 863
            ::...:......:.....::..::....  |..::.|.::|......:......|:..|: |.:|
Human   819 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEI-LDVS 882

  Fly   864 EEE-TQLVSKEVEQVIIIAATALSSESKSSSEEKSVEKELPKEGQAPGENHDEEVKEHQNPPTPY 927
            |:| |..::...|:  :|:..|...:|:...|||.:...:||..|..           ::|..|.
Human   883 EDEGTAHITIMGEE--LISFKAERRDSRDVDEEKELLDFVPKLDQVV-----------ESPAIPR 934

  Fly   928 APPAQPSTP--PPPPKEEAAK--------PPSAAEQPQPNANTVEGMESAAAEPASVGKKTEQME 982
            .|.|.|.|.  ....:|:|:|        |.|.|.:...|.:.|       |.|...|.....| 
Human   935 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPV-------ASPVHTGFLVSFM- 991

  Fly   983 LAEAK------PKPNTNPTPIPPPTAAPPGPPSAESKKPPAAPQPRPSTPQTPTPPQPEPPQREQ 1041
             .:|:      .:.|.....|||.|.|.|...:....||     .:.|||         ||..|:
Human   992 -VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKP-----QKLSTP---------PPLAEE 1041

  Fly  1042 E--TRRSFTLLPSDSADDDPVLNPNSNPPASASDEPAGERKSSFHVLKSDDS--LDESTKRPGRK 1102
            |  ..|...|.|:.:....||:   ...|..|| ...|:|:  ..||:|::.  ..|...|.|..
Human  1042 EGLASRIIALGPTGAQFLSPVI---VEIPHFAS-HGRGDRE--LVVLRSENGSVWKEHRSRYGES 1100

  Fly  1103 -VDYEAGNQVFQVVGEGASAVQLPSAAELEK 1132
             :|     |:...:.|     :|.|..||||
Human  1101 YLD-----QILNGMDE-----ELGSLEELEK 1121

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42534NP_651560.2 Ank_2 127..226 CDD:289560 36/154 (23%)
ANK 193..335 CDD:238125 42/170 (25%)
ANK repeat 195..226 CDD:293786 14/59 (24%)
Ank_5 214..269 CDD:290568 17/54 (31%)
ANK repeat 228..259 CDD:293786 8/30 (27%)
ANK repeat 314..345 CDD:293786 9/30 (30%)
Ank_2 319..412 CDD:289560 30/92 (33%)
ANK 345..468 CDD:238125 39/122 (32%)
ANK repeat 347..379 CDD:293786 9/31 (29%)
ANK repeat 381..412 CDD:293786 12/30 (40%)
ANK 409..538 CDD:238125 41/128 (32%)
ANK repeat 414..479 CDD:293786 21/64 (33%)
ANK repeat 419..445 CDD:293786 7/25 (28%)
Ank_2 420..511 CDD:289560 29/90 (32%)
ANK repeat 481..511 CDD:293786 11/29 (38%)
Ank_2 486..>545 CDD:289560 21/58 (36%)
ANK repeat 516..542 CDD:293786 8/25 (32%)
ANK1XP_011542792.1 ANK 47..163 CDD:238125 24/116 (21%)
ANK repeat 47..75 CDD:293786 5/27 (19%)
ANK 108..229 CDD:238125 32/121 (26%)
ANK repeat 109..140 CDD:293786 7/31 (23%)
Ank_2 114..204 CDD:289560 20/90 (22%)
ANK repeat 143..173 CDD:293786 8/29 (28%)
ANK 170..324 CDD:238125 41/173 (24%)
ANK repeat 175..206 CDD:293786 6/30 (20%)
ANK repeat 208..232 CDD:293786 9/23 (39%)
ANK repeat 241..268 CDD:293786 5/26 (19%)
Ank_2 242..333 CDD:289560 25/110 (23%)
ANK 265..390 CDD:238125 37/144 (26%)
ANK repeat 271..301 CDD:293786 8/29 (28%)
ANK repeat 303..334 CDD:293786 12/50 (24%)
Ank_2 308..397 CDD:289560 27/109 (25%)
ANK repeat 336..367 CDD:293786 9/30 (30%)
ANK repeat 369..400 CDD:293786 9/31 (29%)
Ank 402..432 CDD:278452 12/29 (41%)
ANK repeat 405..433 CDD:293786 12/27 (44%)
ANKYR 406..619 CDD:223738 63/221 (29%)
ANK 430..555 CDD:238125 41/129 (32%)
ANK repeat 435..466 CDD:293786 10/30 (33%)
ANK repeat 468..499 CDD:293786 11/31 (35%)
ANK repeat 501..532 CDD:293786 12/30 (40%)
ANK 529..654 CDD:238125 29/151 (19%)
ANK repeat 534..563 CDD:293786 10/36 (28%)
ANK repeat 568..598 CDD:293786 7/29 (24%)
ANK repeat 600..631 CDD:293786 4/30 (13%)
Ank_2 605..696 CDD:289560 17/111 (15%)
ANK repeat 633..661 CDD:293786 7/46 (15%)
ANK repeat 666..697 CDD:293786 6/32 (19%)
ANK 666..695 CDD:197603 6/30 (20%)
ANK 694..819 CDD:238125 21/155 (14%)
ANK repeat 699..730 CDD:293786 2/39 (5%)
Ank_2 704..795 CDD:289560 12/99 (12%)
ANK repeat 732..763 CDD:293786 1/30 (3%)
ANK repeat 765..796 CDD:293786 9/49 (18%)
Ank_5 785..839 CDD:290568 14/75 (19%)
ANK repeat 798..826 CDD:293786 6/30 (20%)
ZU5 984..1088 CDD:128514 32/125 (26%)
Death_ank1 1474..1557 CDD:260067
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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