DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and INVS

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_055240.2	Gene:	INVS / 27130	HGNCID:	17870	Length:	1065	Species:	Homo sapiens

Alignment Length:	1121	Identity:	242/1121 - (21%)
Similarity:	369/1121 - (32%)	Gaps:	460/1121 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 DAAAEAAVDVPETDPDPAQLTVSQSQSSSTVARRRLAEGCTSLMYACQRG--------------- 134
            ||..:|..||.:||         .||.             |:|..|.|:|
Human    65 DALLKAGADVNKTD---------HSQR-------------TALHLAAQKGNYRFMKLLLTRRANW 107

  Fly   135 ---DIVQV----LAQMREKPELLR------------QRDRSHRNALHYCA--------------- 165
               |:.::    |......|:.|.            .:|::.:.|||:.|
Human   108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHD 172

  Fly   166 ----AQDSEGSKDLVAAAS------------IAIAAP--ELLESADEDGFTPLHLAVIQGNLAMV 212
                ..|.||...|..||:            |..|||  .||...|.:|.||||.||..||:.:|
Human   173 SNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVV 237

  Fly   213 NLLLA-NKADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGASVAKP-DANGGTPLHYAAQMCGA 275
            ::|.: ...::.:.||...:.:|||.:.|..:.:..:|....|...| |:.|.||||||||
Human   238 DVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ---- 298

  Fly   276 SKQDSKQQASSSNSSRLSLEILGILLSHPQSSVDVQDKDGRQPLLWAASAGS---AKAVIALVKA 337
                       ||.:    |.:.:.|.|| |..|..|.:||...:|||..||   .:.:::| |:
Human   299 -----------SNFA----ETVKVFLKHP-SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL-KS 346

  Fly   338 GARVESSDKDGLTALHCAG---------------------------------SRGHTECIDTLI- 368
            ...:..:||.|.||||.|.                                 ..||.:.|.|||
Human   347 DIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411

  Fly   369 GLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPNRQDRKGRTPAHCGCSKGQFETLKL 433
            |  ||..||:|.:|.:.||:|...|:||....|::.:.:||.||..||||..|....|....:.:
Human   412 G--GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474

  Fly   434 LKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNTTSNDGRSLLHIAAANDYTDMC 498
            |.|..|:                                  .|....:||:.||.:..|.|.|..
Human   475 LMENNAD----------------------------------PNIQDKEGRTALHWSCNNGYLDAI 505

  Fly   499 KLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRSTAKFLQANGGQPANKVRLSSRRTGNPFHET 563
            |||||:.|..|.:..|...  .||||.||........:|:..:|.
Human   506 KLLLDFAAFPNQMENNEER--YTPLDYALLGERHEVIQFMLEHGA-------------------- 548

  Fly   564 NATDMVRPLKYVEKEELHDLRSSKKYVVY----LKRSDSDNGNENGKADVGDGDCSCSEQTYRKE 624
                       :....:.|:.:.|...||    ::::..|..|                 ...|.
Human   549 -----------LSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKN-----------------LLMKH 585

  Fly   625 QRLRHVCRRHKRRQLRRRTSSCGESKHERCSEICRSK------SNIEIRRRKSR----------- 672
            ::||......||.:..:| ....:.|..|..:.||.:      |..::..|:||
Human   586 EQLRKDAAAKKREEENKR-KEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNV 649

  Fly   673 -----------------------ERYASS------SEWEEESAEDSC--ENCCYHKRQKDRVVNR 706
                                   |::.||      |....|:|.:..  ::.|.|.|..:
Human   650 AQGPEPRDSRGSPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNE----- 709

  Fly   707 KRSTSSR--------KSKNRDSSD--------------------PDEKNH--------------- 728
             .|..||        ||:...:.|                    ||||..
Human   710 -GSDGSRHPGVPSVEKSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSH 773

  Fly   729 ---SENHS-------SPEK--------------GSRKPLAVNGD--HQADNGKDQTSTKERPPSA 767
               |..|.       :|:|              ||.:|.:..|:  |...|          ||
Human   774 WKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGSARGEAVHAGQN----------PP-- 826

  Fly   768 SRHQTPPTKEGTFIKSPTQSAKSEKSGQMDNLLVEESHAVELTDEEQEAAKSVVTQVDVHHDAEE 832
             .|:||..|          ..:::.:|.:      .||..:.|:|.:..|:.:.|..    .:|:
Human   827 -HHRTPRNK----------VTQAKLTGGL------YSHLPQSTEELRSGARRLETST----LSED 870

  Fly   833 IQTSKSSEEAP----------------------QAEENGKE---KESEQEVKLQLS--------- 863
            .|.||.::.||                      |.|...||   |:::....:|.:
Human   871 FQVSKETDPAPGPLSGQSVNIDLLPVELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKH 935

  Fly   864 -------------------EEETQLV----SKEVEQVIIIAATALS----SESKSSSEEKSVEKE 901
                               :|.|.|:    .||:| :.....||:|    |.||.:|..||.:..
Human   936 LSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELE-LKFPQTTAVSKAPKSPSKGTSGTKSTKHS 999

  Fly   902 LPKEGQAPGENHDEEV 917
            :.|  |..|.:|:.::
Human  1000 VLK--QIYGCSHEGKI 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	37/166 (22%)
		ANK	193..335	CDD:238125	47/146 (32%)
		ANK repeat	195..226	CDD:293786	11/31 (35%)
		Ank_5	214..269	CDD:290568	16/56 (29%)
		ANK repeat	228..259	CDD:293786	7/31 (23%)
		ANK repeat	314..345	CDD:293786	9/33 (27%)
		Ank_2	319..412	CDD:289560	37/129 (29%)
		ANK	345..468	CDD:238125	41/156 (26%)
		ANK repeat	347..379	CDD:293786	17/65 (26%)
		ANK repeat	381..412	CDD:293786	10/30 (33%)
		ANK	409..538	CDD:238125	34/128 (27%)
		ANK repeat	414..479	CDD:293786	10/64 (16%)
		ANK repeat	419..445	CDD:293786	5/25 (20%)
		Ank_2	420..511	CDD:289560	20/90 (22%)
		ANK repeat	481..511	CDD:293786	14/29 (48%)
		Ank_2	486..>545	CDD:289560	21/58 (36%)
		ANK repeat	516..542	CDD:293786	7/25 (28%)
INVS	NP_055240.2	ANK 1	13..42
		Ank_2	19..111	CDD:289560	14/67 (21%)
		ANK	42..169	CDD:238125	23/125 (18%)
		ANK repeat	47..78	CDD:293786	5/12 (42%)
		ANK 2	47..76		5/10 (50%)
		ANK repeat	80..146	CDD:293786	11/78 (14%)
		ANK 3	80..110		7/42 (17%)
		Ank_2	85..179	CDD:289560	13/93 (14%)
		ANK 4	113..144		3/30 (10%)
		ANK	143..309	CDD:238125	51/184 (28%)
		ANK repeat	148..179	CDD:293786	4/30 (13%)
		ANK 5	148..177		4/28 (14%)
		ANK repeat	181..218	CDD:293786	11/36 (31%)
		ANK 6	181..213		9/31 (29%)
		Ank_4	185..240	CDD:290365	20/54 (37%)
		ANK repeat	220..252	CDD:293786	11/31 (35%)
		ANK 7	220..250		11/29 (38%)
		Ank_2	225..319	CDD:289560	35/113 (31%)
		ANK 8	254..283		6/28 (21%)
		ANK repeat	256..286	CDD:293786	7/29 (24%)
		ANK 9	288..317		16/48 (33%)
		ANK repeat	288..313	CDD:293786	15/44 (34%)
		Ank_2	293..387	CDD:289560	32/114 (28%)
		ANK	316..443	CDD:238125	38/129 (29%)
		ANK repeat	321..354	CDD:293786	9/33 (27%)
		ANK 10	321..350		9/29 (31%)
		ANK repeat	356..387	CDD:293786	6/30 (20%)
		ANK 11	356..385		6/28 (21%)
		Ank_2	361..453	CDD:289560	25/93 (27%)
		ANK	384..509	CDD:238125	43/160 (27%)
		ANK repeat	389..420	CDD:293786	11/32 (34%)
		ANK 12	389..418		9/30 (30%)
		ANK repeat	422..453	CDD:293786	10/30 (33%)
		ANK 13	422..451		9/28 (32%)
		Ank_2	427..517	CDD:289560	34/123 (28%)
		ANK repeat	455..486	CDD:293786	10/64 (16%)
		ANK 14	455..484		9/62 (15%)
		ANK 15	488..517		13/28 (46%)
		ANK repeat	488..516	CDD:293786	13/27 (48%)
		D-box 1	490..498		3/7 (43%)
		ANK repeat	521..548	CDD:293786	8/28 (29%)
		ANK 16	523..553		8/62 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..833		46/263 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..886		11/42 (26%)
		D-box 2	909..917		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..999		9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000