DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42534 and Mib1

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_001351926.1	Gene:	Mib1 / 225164	MGIID:	2443157	Length:	1006	Species:	Mus musculus

Alignment Length:	765	Identity:	174/765 - (22%)
Similarity:	278/765 - (36%)	Gaps:	216/765 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 DPAQLTVSQSQSSSTVARRRLAEGCTSLMYACQRGDIVQVLAQMREKPELLRQRDRSHRNAL--- 161
            :||.||.:....|...|:.  |||.||..   |.||:|||...: |:.:||::.......|:
Mouse   307 NPAVLTKANIVRSGDAAQG--AEGGTSQF---QVGDLVQVCYDL-ERIKLLQRGHGEWAEAMLPT 365

  Fly   162 ------------------HYC-------------------AAQDSEG------------------ 171
                              ..|                   |..::.|
Mouse   366 LGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVAPAGSAISNASGERLSQLLKKLFETQESGD 430

  Fly   172 -SKDLVAAASIAIAA--PELLESADED------GFTPLHLAVIQGNLAMVNLLLANKADVNAVDN 227
             :::||.||:....|  .:||:..|.|      |.|.:..|...|::.::.|||....||.|.|.
Mouse   431 LNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDK 495

  Fly   228 EGHSVVHWATVCGEVESLRAVLAAGASVAKPDANG-----GTPLHYAAQMCGASKQDSKQQASSS 287
            :|...||.|.. |:..::..||..|::    |.|.     .||||.|.
Mouse   496 DGDRAVHHAAF-GDEGAVIEVLHRGSA----DLNARNKRRQTPLHIAV----------------- 538

  Fly   288 NSSRLSLEILGILLS---HPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGL 349
              ::..|:::..||.   ||    .:||.:|..||..|.|......:..|::|||.|..::.:|.
Mouse   539 --NKGHLQVVKTLLDFGCHP----SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGF 597

  Fly   350 TALHCAGSRGHTECIDTLIGLCGAP--TDLIDSNGCTALHYAVTLGHADATARLLDLEADPNR-- 410
            .|||.|..||:...:..|:.....|  .|....:|.||||.|....|.: .|.||..:.:.|.
Mouse   598 NALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVE-VAELLVHQGNANLDI 661

  Fly   411 QDRKGRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQV 475
            |:...:|..|....:...:.::||...||.|.:::..||.|||||...
Mouse   662 QNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH----------------- 709

  Fly   476 NTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTPL--DGALQRGHRSTAKFL 538
                   .:|..:....|..|:.|        |:|.:..|:..::..|  .||.::...|.|.||
Mouse   710 -------HTLSQLRQLQDMQDVGK--------VDAAWEPSKNTLIMGLGTQGAEKKSAASIACFL 759

  Fly   539 QANGGQPANKVRLSSRRTGNPFHETNATDMVRPLKYVEKEELHDLRSSKKYVVYLKRSDSDNGNE 603
            .|||..    :.:.:::..:|........:.:.|....||::.....|:.  ..:..:||:...|
Mouse   760 AANGAD----LSIRNKKGQSPLDLCPDPSLCKALAKCHKEKVSGQVGSRS--PSMISNDSETLEE 818

  Fly   604 -----NGKADVGDGDC----SCSEQTYRKEQRLRHVCRRHKRRQLRRRTS-----SCGESK---- 650
                 :.|.|...|.|    :||..:.|.::.|  :|    :.|::.||.     .|.:.|
Mouse   819 CMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCL--IC----KEQVQSRTKIEECVVCSDKKAAVL 877

  Fly   651 HERCSEICRSKSNIEIRRRKSRERYASSSEWEEESAEDSCENCC--YHKRQKDRVVNRKRSTSSR 713
            .:.|..:|                              :||||.  ..|..:.|.|..:|.....
Mouse   878 FQPCGHMC------------------------------ACENCASLMKKCVQCRAVVERRVPFIT 912

  Fly   714 KSKNRDSSDPDEKNHSENHSSPEKGSRKPLAVNGD-----HQADNGKDQT 758
            ....:.|.||.::..|.|....:| .:....||.|     .|..:.|:||
Mouse   913 CCGGKSSEDPSDEISSGNIPVLQK-DKDNTNVNADVQKLQQQLQDIKEQT 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	32/165 (19%)
		ANK	193..335	CDD:238125	40/155 (26%)
		ANK repeat	195..226	CDD:293786	11/36 (31%)
		Ank_5	214..269	CDD:290568	21/59 (36%)
		ANK repeat	228..259	CDD:293786	8/30 (27%)
		ANK repeat	314..345	CDD:293786	10/30 (33%)
		Ank_2	319..412	CDD:289560	29/96 (30%)
		ANK	345..468	CDD:238125	36/126 (29%)
		ANK repeat	347..379	CDD:293786	10/33 (30%)
		ANK repeat	381..412	CDD:293786	11/32 (34%)
		ANK	409..538	CDD:238125	28/132 (21%)
		ANK repeat	414..479	CDD:293786	14/64 (22%)
		ANK repeat	419..445	CDD:293786	6/25 (24%)
		Ank_2	420..511	CDD:289560	18/90 (20%)
		ANK repeat	481..511	CDD:293786	5/29 (17%)
		Ank_2	486..>545	CDD:289560	16/60 (27%)
		ANK repeat	516..542	CDD:293786	8/27 (30%)
Mib1	NP_001351926.1	MIB_HERC2	15..71	CDD:369043
		ZZ_Mind_bomb	83..127	CDD:239079
		MIB_HERC2	154..218	CDD:369043
		SH3_15	246..311	CDD:375773	2/3 (67%)
		SH3_15	333..397	CDD:375773	11/67 (16%)
		ANK 1	430..460		9/29 (31%)
		PHA03095	439..>710	CDD:222980	85/323 (26%)
		ANK 2	463..492		9/28 (32%)
		ANK repeat	464..494	CDD:293786	10/29 (34%)
		ANK repeat	496..560	CDD:293786	20/91 (22%)
		ANK 3	496..525		9/33 (27%)
		ANK 4	529..558		10/51 (20%)
		ANK repeat	562..593	CDD:293786	10/30 (33%)
		ANK 5	562..591		10/28 (36%)
		ANK 6	595..627		9/31 (29%)
		ANK repeat	631..663	CDD:293786	11/32 (34%)
		ANK 7	631..661		11/30 (37%)
		ANK repeat	665..696	CDD:293786	7/30 (23%)
		ANK 8	665..694		7/28 (25%)
		Ank_2	670..770	CDD:372319	30/135 (22%)
		ANK 9	698..729		12/62 (19%)
		RING1-HC_MIB1	818..854	CDD:319638	10/41 (24%)
		RING-HC finger (C3HC4-type)	819..853	CDD:319638	8/35 (23%)
		RING2-HC_MIB1	865..901	CDD:319639	9/65 (14%)
		RING-HC finger (C3HC4-type)	866..900	CDD:319639	9/63 (14%)
		RING3-HC_MIB1	962..1003	CDD:319641	174/765 (23%)
		RING-HC finger (C3HC4-type)	963..995	CDD:319641
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000