DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42534 and trp-4

DIOPT Version :9

Sequence 1:	NP_651560.2	Gene:	CG42534 / 43298	FlyBaseID:	FBgn0260487	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_493429.2	Gene:	trp-4 / 190574	WormBaseID:	WBGene00006616	Length:	1924	Species:	Caenorhabditis elegans

Alignment Length:	653	Identity:	155/653 - (23%)
Similarity:	265/653 - (40%)	Gaps:	100/653 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LKAAKKQLQFESP---LPRRTRTMQQQQQQD------NDHPPQQEKQEQQQQQQQRQEAADK--- 73
            |:.|.|...||:.   |...:..:.|:|.::      ||.........:.:|:|......|.
Worm   766 LQVAAKSCNFEAASMILKHLSEVLTQEQLKEHVNHRTNDGFTALHYAAEIEQRQLHFPGEDAKLV 830

  Fly    74 --------VIAMPGSSQDTDAAAEAAVDVPETDPDPAQLTVSQSQ----SSSTVARRRLAEGCTS 126
                    ::.||..:     |.|.|:.:.....:.|.|....::    :...|..::...|.:.
Worm   831 NLLIDYGGMVEMPSLN-----ANETAMHMAARSGNQAVLLAMVNKIGAGAVQIVQNKQSKNGWSP 890

  Fly   127 LMYACQRG--DIVQVLAQMREKPELLRQRDRSHRNALHYCAAQDSEGSKDLVAAASIAIAAPELL 189
            |:.||.||  .:..:|.:...:.::.   |...|.|||..|   ..|...||   .:.:.....:
Worm   891 LLEACARGHSGVANILLKHHARIDVF---DEMGRTALHLAA---FNGHLSLV---HLLLQHKAFV 946

  Fly   190 ESADEDGFTPLHLAVIQGNLAMVNLLLANK-ADVNAVDNEGHSVVHWATVCGEVESLRAVLAAGA 253
            .|..:.|..|||||...|::.:||:|:.:. |.:.|:..:..:.:|:|...|::...:.:||.||
Worm   947 NSKSKTGEAPLHLAAQHGHVKVVNVLVQDHGAALEAITLDNQTALHFAAKFGQLAVSQTLLALGA 1011

  Fly   254 SVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRL------------------SLEILGIL 300
            :....|..|.||||.||:...........:..::|.|.|                  ||.::..|
Worm  1012 NPNARDDKGQTPLHLAAENDFPDVVKLFLKMRNNNRSVLTAIDHNGFTCAHIAAMKGSLAVVREL 1076

  Fly   301 LSHPQSSVDVQDKD---GRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGH-- 360
            :...:..| :|.|.   ....|..||:.|.|..|..|::.||..|..:..|:||||.....|.
Worm  1077 MMIDKPMV-IQAKTKTLEATTLHMAAAGGHANIVKILLENGANAEDENSHGMTALHLGAKNGFIS 1140

  Fly   361 -TECIDTLI-GLCGAPTDLIDSNGCTALHYAVTLGHADATARLL-----DLEADP---NRQDRK- 414
             .|..|.:: ..|...|      |..|||.|...|::|....:|     .:.::|   |....|
Worm  1141 ILEAFDKILWKRCSRKT------GLNALHIAAFYGNSDFVNEMLKHVQATVRSEPPIYNHHVNKE 1199

  Fly   415 -----GRTPAHCGCSKGQFETLKLLKERGANLWLRNAKGD-LPLHEAAASGRRELLEWLLAQRPK 473
                 |.||.|.....|....:::|..:|..:...:...: :|||.||..|...::..||::..:
Worm  1200 FSTEYGFTPLHLAAQSGHDSLVRMLLNQGVQVDATSTTMNVIPLHLAAQQGHIAVVGMLLSRSTQ 1264

  Fly   474 QVNTTSNDGRSLLHIAAANDYTDMCKLLLDYGADVNAVYRNSRGLVLTPLDGALQRGHRSTAKFL 538
            |.:.....||:.||:||.|.:.:|..||:..|:::|.:.:|.    .|.|..|.:.||.|..|..
Worm  1265 QQHAKDWRGRTPLHLAAQNGHYEMVSLLIAQGSNINVMDQNG----WTGLHFATRAGHLSVVKLF 1325

  Fly   539 QANGGQPANKVRLSSRRTGN-PFHETNATDMVRPLKYV--EKEELHDLRSSKKYVVYLKRSDSDN 600
            ..:...|     |:..:.|. |.....|.:.:..|:::  :|.:.|.|...:|::..|......|
Worm  1326 IDSSADP-----LAETKEGKVPLCFAAAHNHIECLRFLLKQKHDTHQLMEDRKFIFDLMVCGKTN 1385

  Fly   601 GNE 603
            .||
Worm  1386 DNE 1388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42534	NP_651560.2	Ank_2	127..226	CDD:289560	28/101 (28%)
		ANK	193..335	CDD:238125	42/163 (26%)
		ANK repeat	195..226	CDD:293786	12/31 (39%)
		Ank_5	214..269	CDD:290568	16/55 (29%)
		ANK repeat	228..259	CDD:293786	7/30 (23%)
		ANK repeat	314..345	CDD:293786	10/33 (30%)
		Ank_2	319..412	CDD:289560	30/104 (29%)
		ANK	345..468	CDD:238125	34/141 (24%)
		ANK repeat	347..379	CDD:293786	10/35 (29%)
		ANK repeat	381..412	CDD:293786	10/38 (26%)
		ANK	409..538	CDD:238125	38/135 (28%)
		ANK repeat	414..479	CDD:293786	17/71 (24%)
		ANK repeat	419..445	CDD:293786	4/25 (16%)
		Ank_2	420..511	CDD:289560	25/91 (27%)
		ANK repeat	481..511	CDD:293786	12/29 (41%)
		Ank_2	486..>545	CDD:289560	18/58 (31%)
		ANK repeat	516..542	CDD:293786	7/25 (28%)
trp-4	NP_493429.2	ANK repeat	804..842	CDD:293786	4/37 (11%)
		ANK repeat	849..884	CDD:293786	5/34 (15%)
		ANK repeat	886..917	CDD:293786	7/33 (21%)
		ANK repeat	919..950	CDD:293786	9/36 (25%)
		ANK repeat	952..982	CDD:293786	11/29 (38%)
		ANK repeat	986..1017	CDD:293786	7/30 (23%)
		PHA03095	1006..>1336	CDD:222980	90/345 (26%)
		ANK repeat	1092..1123	CDD:293786	10/30 (33%)
		ANK repeat	1204..1236	CDD:293786	7/31 (23%)
		trp	1209..1879	CDD:273311	47/189 (25%)
		ANK repeat	1238..1270	CDD:293786	9/31 (29%)
		ANK repeat	1272..1303	CDD:293786	12/30 (40%)
		ANK repeat	1305..1336	CDD:293786	10/39 (26%)
		ANK repeat	1338..1366	CDD:293786	5/27 (19%)
		ANKYR	280..515	CDD:223738
		ANK repeat	352..383	CDD:293786
		ANK repeat	385..418	CDD:293786
		ANK repeat	424..454	CDD:293786
		PHA03095	430..>756	CDD:222980
		ANK repeat	456..489	CDD:293786
		ANK repeat	491..523	CDD:293786
		ANK repeat	526..556	CDD:293786
		ANK repeat	558..590	CDD:293786
		ANK repeat	592..623	CDD:293786
		ANK repeat	625..656	CDD:293786
		ANK repeat	658..688	CDD:293786
		ANK repeat	692..726	CDD:293786
		PHA02876	<712..>1040	CDD:165207	65/287 (23%)
		ANK repeat	728..753	CDD:293786
		ANK repeat	761..802	CDD:293786	8/35 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000